|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 127, Issue 13 2785-2794, Copyright © 2000 by Company of Biologists
JOURNAL ARTICLES |
J Huynh and D St Johnston
The Wellcome/CRC Institute and the Department of Genetics, University of Cambridge, Tennis Court Rd, Cambridge, CB2 1QR, UK.
The oocyte is the only cell in Drosophila that goes through meiosis with meiotic recombination, but several germ cells in a 16-cell cyst enter meiosis and form synaptonemal complexes (SC) before one cell is selected to become the oocyte. Using an antibody that recognises a component of the SC or the synapsed chromosomes, we have analysed how meiosis becomes restricted to one cell, in relation to the other events in oocyte determination. Although BicD and egl mutants both cause the development of cysts with no oocyte, they have opposite effects on the behaviour of the SC: none of the cells in the cyst form SC in BicD null mutants, whereas all of the cells do in egl and orb mutants. Furthermore, unlike all cytoplasmic markers for the oocyte, the SC still becomes restricted to one cell when the microtubules are depolymerised, even though the BicD/Egl complex is not localised. These results lead us to propose a model in which BicD, Egl and Orb control entry into meiosis by regulating translation.
This article has been cited by other articles:
|
|
 |
|
  P. Benoit, C. Papin, J. E. Kwak, M. Wickens, and M. Simonelig PAP- and GLD-2-type poly(A) polymerases are required sequentially in cytoplasmic polyadenylation and oogenesis in Drosophila Development, June 1, 2008; 135(11): 1969 - 1979. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Barbosa, N. Kimm, and R. Lehmann A Maternal Screen for Genes Regulating Drosophila Oocyte Polarity Uncovers New Steps in Meiotic Progression Genetics, August 1, 2007; 176(4): 1967 - 1977. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Kimble and D. C. Page The Mysteries of Sexual Identity: The Germ Cell's Perspective Science, April 20, 2007; 316(5823): 400 - 401. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-B. Coutelis and A. Ephrussi Rab6 mediates membrane organization and determinant localization during Drosophila oogenesis Development, April 1, 2007; 134(7): 1419 - 1430. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Roper Rtnl1 is enriched in a specialized germline ER that associates with ribonucleoprotein granule components J. Cell Sci., March 15, 2007; 120(6): 1081 - 1092. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. McCaffrey, D. St Johnston, and A. Gonzalez-Reyes Drosophila mus301/spindle-C Encodes a Helicase With an Essential Role in Double-Strand DNA Break Repair and Meiotic Progression Genetics, November 1, 2006; 174(3): 1273 - 1285. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Mirouse, E. Formstecher, and J.-L. Couderc Interaction between Polo and BicD proteins links oocyte determination and meiosis control in Drosophila Development, October 15, 2006; 133(20): 4005 - 4013. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. E. Thompson, D. S. Bernstein, J. L. Bachorik, A. G. Petcherski, M. Wickens, and J. Kimble Dose-dependent control of proliferation and sperm specification by FOG-1/CPEB Development, August 1, 2005; 132(15): 3471 - 3481. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Iida and M. A. Lilly missing oocyte encodes a highly conserved nuclear protein required for the maintenance of the meiotic cycle and oocyte identity in Drosophila Development, March 1, 2004; 131(5): 1029 - 1039. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Abdu, A. Gonzalez-Reyes, A. Ghabrial, and T. Schupbach The Drosophila spn-D Gene Encodes a RAD51C-Like Protein That Is Required Exclusively During Meiosis Genetics, September 1, 2003; 165(1): 197 - 204. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Z. Morris, C. Navarro, and R. Lehmann Identification and Analysis of Mutations in bob, Doa and Eight New Genes Required for Oocyte Specification and Development in Drosophila melanogaster Genetics, August 1, 2003; 164(4): 1435 - 1446. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Hong, S. Lee-Kong, T. Iida, I. Sugimura, and M. A. Lilly The p27cip/kip ortholog dacapo maintains the Drosophila oocyte in prophase of meiosis I Development, April 1, 2003; 130(7): 1235 - 1242. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. D. Findley, M. Tamanaha, N. J. Clegg, and H. Ruohola-Baker Maelstrom, a Drosophila spindle-class gene, encodes a protein that colocalizes with Vasa and RDE1/AGO1 homolog, Aubergine, in nuage Development, March 1, 2003; 130(5): 859 - 871. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Mathe, Y. H. Inoue, W. Palframan, G. Brown, and D. M. Glover Orbit/Mast, the CLASP orthologue of Drosophila, is required for asymmetric stem cell and cystocyte divisions and development of the polarised microtubule network that interconnects oocyte and nurse cells during oogenesis Development, March 1, 2003; 130(5): 901 - 915. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Minestrini, E. Mathe, and D. M. Glover Domains of the Pavarotti kinesin-like protein that direct its subcellular distribution: effects of mislocalisation on the tubulin and actin cytoskeleton during Drosophila oogenesis J. Cell Sci., February 15, 2002; 115(4): 725 - 736. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Doronkin, I. Djagaeva, and S. K. Beckendorf CSN5/Jab1 mutations affect axis formation in the Drosophila oocyte by activating a meiotic checkpoint Development, January 11, 2002; 129(21): 5053 - 5064. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. N. Cox, S. A. Seyfried, L. Y. Jan, and Y. N. Jan Bazooka and atypical protein kinase C are required to regulate oocyte differentiation in the Drosophila ovary PNAS, December 4, 2001; 98(25): 14475 - 14480. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. L. Page and R. S. Hawley c(3)G encodes a Drosophila synaptonemal complex protein Genes & Dev., December 1, 2001; 15(23): 3130 - 3143. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J Bolvar, J. Huynh, H Lpez-Schier, C Gonzlez, D St Johnston, and A Gonzlez-Reyes Centrosome migration into the Drosophila oocyte is independent of BicD and egl, and of the organisation of the microtubule cytoskeleton Development, January 5, 2001; 128(10): 1889 - 1897. [Abstract] [PDF]
|
|
|
|
|
|
J. Huynh, J. Shulman, R Benton, and D St Johnston PAR-1 is required for the maintenance of oocyte fate in Drosophila Development, January 4, 2001; 128(7): 1201 - 1209. [Abstract] [PDF]
|
|
|
|
|
|
C. Luitjens, M. Gallegos, B. Kraemer, J. Kimble, and M. Wickens CPEB proteins control two key steps in spermatogenesis in C. elegans Genes & Dev., October 15, 2000; 14(20): 2596 - 2609. [Abstract] [Full Text]
|
|
|
|
 |
|
 E. A. Manheim, J. K. Jang, D. Dominic, and K. S. McKim Cytoplasmic Localization and Evolutionary Conservation of MEI-218, a Protein Required for Meiotic Crossing-over in Drosophila Mol. Biol. Cell, January 1, 2002; 13(1): 84 - 95. [Abstract] [Full Text] [PDF]
|
|
