|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 127, Issue 14 3021-3030, Copyright © 2000 by Company of Biologists
JOURNAL ARTICLES |
L Cai, EM Morrow and CL Cepko
Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.
To investigate the role(s) of basic helix-loop-helix genes (bHLH) genes in the developing murine cerebral cortex, Mash1, Math2, Math3, Neurogenin1 (Ngn1), Ngn2, NeuroD, NeuroD2 and Id1 were transduced in vivo into the embryonic and postnatal cerebral cortex using retrovirus vectors. The morphology and location of infected cells were analyzed at postnatal stages. The data indicate that a subset of bHLH genes are capable of regulating the choice of neuronal versus glial fate and that, when misexpressed, they can be deleterious to the survival of differentiating neurons, but not glia.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  M. C. Havrda, B. T. Harris, A. Mantani, N. M. Ward, B. R. Paolella, V. C. Cuzon, H. H. Yeh, and M. A. Israel Id2 Is Required for Specification of Dopaminergic Neurons during Adult Olfactory Neurogenesis J. Neurosci., December 24, 2008; 28(52): 14074 - 14087. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Peddada, D. H. Yasui, and J. M. LaSalle Inhibitors of differentiation (ID1, ID2, ID3 and ID4) genes are neuronal targets of MeCP2 that are elevated in Rett syndrome Hum. Mol. Genet., June 15, 2006; 15(12): 2003 - 2014. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Wildner, T. Muller, S.-H. Cho, D. Brohl, C. L. Cepko, F. Guillemot, and C. Birchmeier dILA neurons in the dorsal spinal cord are the product of terminal and non-terminal asymmetric progenitor cell divisions, and require Mash1 for their development Development, June 1, 2006; 133(11): 2105 - 2113. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Urano, M. Iiduka, A. Sugiyama, H. Akiyama, K. Uzawa, G. Matsumoto, Y. Kawasaki, and F. Tashiro Involvement of the Mouse Prp19 Gene in Neuronal/Astroglial Cell Fate Decisions J. Biol. Chem., March 17, 2006; 281(11): 7498 - 7514. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Scheffler, N. M. Walton, D. D. Lin, A. K. Goetz, G. Enikolopov, S. N. Roper, and D. A. Steindler Phenotypic and functional characterization of adult brain neuropoiesis PNAS, June 28, 2005; 102(26): 9353 - 9358. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Oldekamp, N. Kraemer, G. Alvarez-Bolado, and T. Skutella bHLH Gene Expression in the Emx2-deficient Dentate Gyrus Reveals Defective Granule Cells and Absence of Migrating Precursors Cereb Cortex, September 1, 2004; 14(9): 1045 - 1058. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Nakada, T. L. Hunsaker, R. M. Henke, and J. E. Johnson Distinct domains within Mash1 and Math1 are required for function in neuronal differentiation versus neuronal cell-type specification Development, March 15, 2004; 131(6): 1319 - 1330. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Sakamoto, H. Hirata, T. Ohtsuka, Y. Bessho, and R. Kageyama The Basic Helix-Loop-Helix Genes Hesr1/Hey1 and Hesr2/Hey2 Regulate Maintenance of Neural Precursor Cells in the Brain J. Biol. Chem., November 7, 2003; 278(45): 44808 - 44815. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Gotz Glial Cells Generate Neurons--Master Control within CNS Regions: Developmental Perspectives on Neural Stem Cells Neuroscientist, October 1, 2003; 9(5): 379 - 397. [Abstract] [PDF]
|
|
|
|
|
|
P. J. Ebert, J. R. Timmer, Y. Nakada, A. W. Helms, P. B. Parab, Y. Liu, T. L. Hunsaker, and J. E. Johnson Zic1 represses Math1 expression via interactions with the Math1 enhancer and modulation of Math1 autoregulation Development, May 1, 2003; 130(9): 1949 - 1959. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Dubreuil, M.-R. Hirsch, C. Jouve, J.-F. Brunet, and C. Goridis The role of Phox2b in synchronizing pan-neuronal and type-specific aspects of neurogenesis Development, March 13, 2003; 129(22): 5241 - 5253. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-i. Ohnuma, S. Hopper, K. C. Wang, A. Philpott, and W. A. Harris Co-ordinating retinal histogenesis: early cell cycle exit enhances early cell fate determination in the Xenopus retina Development, March 7, 2003; 129(10): 2435 - 2446. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Inoue, M. Hojo, Y. Bessho, Y. Tano, J. E. Lee, and R. Kageyama Math3 and NeuroD regulate amacrine cell fate specification in the retina Development, March 4, 2003; 129(4): 831 - 842. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Kirby, F. M. Menzies, M. R. Cookson, K. Bushby, and P. J. Shaw Differential gene expression in a cell culture model of SOD1-related familial motor neurone disease Hum. Mol. Genet., August 15, 2002; 11(17): 2061 - 2075. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Kabos, A. Kabosova, and T. Neuman Blocking HES1 Expression Initiates GABAergic Differentiation and Induces the Expression of p21CIP1/WAF1 in Human Neural Stem Cells J. Biol. Chem., March 8, 2002; 277(11): 8763 - 8766. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Lopez-Rovira, E. Chalaux, J. Massague, J. L. Rosa, and F. Ventura Direct Binding of Smad1 and Smad4 to Two Distinct Motifs Mediates Bone Morphogenetic Protein-specific Transcriptional Activation of Id1 Gene J. Biol. Chem., January 25, 2002; 277(5): 3176 - 3185. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Lo, E. Dormand, A. Greenwood, and D. J. Anderson Comparison of the generic neuronal differentiation and neuron subtype specification functions of mammalian achaete-scute and atonal homologs in cultured neural progenitor cells Development, January 4, 2002; 129(7): 1553 - 1567. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Satow, S.-K. Bae, T. Inoue, C. Inoue, G. Miyoshi, K. Tomita, Y. Bessho, N. Hashimoto, and R. Kageyama The Basic Helix-Loop-Helix Gene hesr2 Promotes Gliogenesis in Mouse Retina J. Neurosci., February 15, 2001; 21(4): 1265 - 1273. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J Hatakeyama, K Tomita, T Inoue, and R Kageyama Roles of homeobox and bHLH genes in specification of a retinal cell type Development, January 4, 2001; 128(8): 1313 - 1322. [Abstract] [PDF]
|
|
|
|
|
|
A. Stoykova, D. Treichel, M. Hallonet, and P. Gruss Pax6 Modulates the Dorsoventral Patterning of the Mammalian Telencephalon J. Neurosci., November 1, 2000; 20(21): 8042 - 8050. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Ohtsuka, M. Sakamoto, F. Guillemot, and R. Kageyama Roles of the Basic Helix-Loop-Helix Genes Hes1 and Hes5 in Expansion of Neural Stem Cells of the Developing Brain J. Biol. Chem., August 3, 2001; 276(32): 30467 - 30474. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Nakashima, T. Takizawa, W. Ochiai, M. Yanagisawa, T. Hisatsune, M. Nakafuku, K. Miyazono, T. Kishimoto, R. Kageyama, and T. Taga BMP2-mediated alteration in the developmental pathway of fetal mouse brain cells from neurogenesis to astrocytogenesis PNAS, May 8, 2001; 98(10): 5868 - 5873. [Abstract] [Full Text] [PDF]
|
|
