|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 127, Issue 14 3091-3100, Copyright © 2000 by Company of Biologists
JOURNAL ARTICLES |
A Djiane, J Riou, M Umbhauer, J Boucaut and D Shi
Groupe de Biologie Experimentale, Laboratoire de Biologie Moleculaire et Cellulaire du Developpement, CNRS UMR 7622, Universite Pierre et Marie Curie, 75005 Paris, France.
Wnt signalling plays a crucial role in the control of morphogenetic movements. We describe the expression and functional analyses of frizzled 7 (Xfz7) during gastrulation in Xenopus. Low levels of Xfz7 transcripts are expressed maternally during cleavage stages; its zygotic expression strongly increases at the beginning of gastrulation and is predominantly localized to the presumptive neuroectoderm and deep cells of the involuting mesoderm. Overexpression of Xfz7 in the dorsal equatorial region affects the movements of convergent extension and delays mesodermal involution. It alters the correct localization, but not the expression, of mesodermal and neural markers. These effects can be rescued by extra-Xfz7, which is a secreted form of the receptor that also weakly inhibits convergent extension when overexpressed. This suggests that the wild-type and truncated receptors have opposing effects when coexpressed and that overexpression of Xfz7 causes an increased signalling activity. Consistent with this, Xfz7 biochemically and functionally interacts with Xwnt11. In addition, Dishevelled, but not (&bgr;)-catenin, synergizes with Xfz7 to affect convergent extension. Furthermore, overexpression of Xfz7 and Xwnt11 also affects convergent extension in activin-treated animal caps, and this can be efficiently reversed by coexpression of Cdc42(T17N), a dominant negative mutant of the small GTPase Cdc42 known as a key regulator of actin cytoskeleton. Conversely, Cdc42(G12V), a constitutively active mutant, rescues the effects of extra-Xfz7 on convergent extension in a dose-dependent manner. That both gain-of-function and loss-of-function of both frizzled and dishevelled produce the same phenotype has been well described in Drosophila tissue polarity. Therefore, our results suggest an endogenous role of Xfz7 in the regulation of convergent extension during gastrulation.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  J. L. Fetting, S. A. Spencer, and T. Wolff The cell adhesion molecules Echinoid and Friend of Echinoid coordinate cell adhesion and cell signaling to regulate the fidelity of ommatidial rotation in the Drosophila eye Development, October 1, 2009; 136(19): 3323 - 3333. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. K. Vladar, D. Antic, and J. D. Axelrod Planar Cell Polarity Signaling: The Developing Cell's Compass Cold Spring Harb Perspect Biol, September 1, 2009; 1(3): a002964 - a002964. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Shao, Z.-Z. Liu, C.-D. Wang, H.-Y. Li, C. Carron, H.-W. Zhang, and D.-L. Shi Down syndrome critical region protein 5 regulates membrane localization of Wnt receptors, Dishevelled stability and convergent extension in vertebrate embryos Development, June 15, 2009; 136(12): 2121 - 2131. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Schlessinger, A. Hall, and N. Tolwinski Wnt signaling pathways meet Rho GTPases Genes & Dev., February 1, 2009; 23(3): 265 - 277. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Carreira-Barbosa, M. Kajita, V. Morel, H. Wada, H. Okamoto, A. Martinez Arias, Y. Fujita, S. W. Wilson, and M. Tada Flamingo regulates epiboly and convergence/extension movements through cell cohesive and signalling functions during zebrafish gastrulation Development, February 1, 2009; 136(3): 383 - 392. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-W. Cha, E. Tadjuidje, Q. Tao, C. Wylie, and J. Heasman Wnt5a and Wnt11 interact in a maternal Dkk1-regulated fashion to activate both canonical and non-canonical signaling in Xenopus axis formation Development, November 15, 2008; 135(22): 3719 - 3729. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G.-H. Kim, J.-H. Her, and J.-K. Han Ryk cooperates with Frizzled 7 to promote Wnt11-mediated endocytosis and is essential for Xenopus laevis convergent extension movements J. Cell Biol., September 22, 2008; 182(6): 1073 - 1082. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Luyten, E. Mortier, C. Van Campenhout, V. Taelman, G. Degeest, G. Wuytens, K. Lambaerts, G. David, E. J. Bellefroid, and P. Zimmermann The Postsynaptic Density 95/Disc-Large/Zona Occludens Protein Syntenin Directly Interacts with Frizzled 7 and Supports Noncanonical Wnt Signaling Mol. Biol. Cell, April 1, 2008; 19(4): 1594 - 1604. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. M. Spagnoli and A. H. Brivanlou The Gata5 target, TGIF2, defines the pancreatic region by modulating BMP signals within the endoderm Development, February 1, 2008; 135(3): 451 - 461. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Yamanaka and E. Nishida Wnt11 stimulation induces polarized accumulation of Dishevelled at apical adherens junctions through Frizzled7 Genes Cells, August 1, 2007; 12(8): 961 - 967. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Witzel, V. Zimyanin, F. Carreira-Barbosa, M. Tada, and C.-P. Heisenberg Wnt11 controls cell contact persistence by local accumulation of Frizzled 7 at the plasma membrane J. Cell Biol., December 4, 2006; 175(5): 791 - 802. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Sato, D. K. Khadka, W. Liu, R. Bharti, L. W. Runnels, I. B. Dawid, and R. Habas Profilin is an effector for Daam1 in non-canonical Wnt signaling and is required for vertebrate gastrulation Development, November 1, 2006; 133(21): 4219 - 4231. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Borchers, Y. Fonar, D. Frank, and J. C. Baker XNF-ATc3 affects neural convergent extension Development, May 1, 2006; 133(9): 1745 - 1755. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. M. Cadigan and Y. I. Liu Wnt signaling: complexity at the surface J. Cell Sci., February 1, 2006; 119(3): 395 - 402. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. H. Price, D. M. Roberts, B. M. McCartney, E. Jezuit, and M. Peifer Cytoskeletal dynamics and cell signaling during planar polarity establishment in the Drosophila embryonic denticle J. Cell Sci., February 1, 2006; 119(3): 403 - 415. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Kwan and M. W. Kirschner A microtubule-binding Rho-GEF controls cell morphology during convergent extension of Xenopus laevis Development, October 15, 2005; 132(20): 4599 - 4610. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P.-H. Puech, A. Taubenberger, F. Ulrich, M. Krieg, D. J. Muller, and C.-P. Heisenberg Measuring cell adhesion forces of primary gastrulating cells from zebrafish using atomic force microscopy J. Cell Sci., September 15, 2005; 118(18): 4199 - 4206. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. H. Fong, A. Emelyanov, C. Teh, and V. Korzh Wnt signalling mediated by Tbx2b regulates cell migration during formation of the neural plate Development, August 15, 2005; 132(16): 3587 - 3596. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. De Calisto, C. Araya, L. Marchant, C. F. Riaz, and R. Mayor Essential role of non-canonical Wnt signalling in neural crest migration Development, June 1, 2005; 132(11): 2587 - 2597. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Das, A. Jenny, T. J. Klein, S. Eaton, and M. Mlodzik Diego interacts with Prickle and Strabismus/Van Gogh to localize planar cell polarity complexes Development, September 15, 2004; 131(18): 4467 - 4476. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Mercurio, B. Latinkic, N. Itasaki, R. Krumlauf, and J. C. Smith Connective-tissue growth factor modulates WNT signalling and interacts with the WNT receptor complex Development, May 1, 2004; 131(9): 2137 - 2147. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Ulrich, M. L. Concha, P. J. Heid, E. Voss, S. Witzel, H. Roehl, M. Tada, S. W. Wilson, R. J. Adams, D. R. Soll, et al. Slb/Wnt11 controls hypoblast cell migration and morphogenesis at the onset of zebrafish gastrulation Development, November 15, 2003; 130(22): 5375 - 5384. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Strutt Frizzled signalling and cell polarisation in Drosophila and vertebrates Development, October 1, 2003; 130(19): 4501 - 4513. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Carreira-Barbosa, M. L. Concha, M. Takeuchi, N. Ueno, S. W. Wilson, and M. Tada Prickle 1 regulates cell movements during gastrulation and neuronal migration in zebrafish Development, September 1, 2003; 130(17): 4037 - 4046. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Majumdar, S. Vainio, A. Kispert, J. McMahon, and A. P. McMahon Wnt11 and Ret/Gdnf pathways cooperate in regulating ureteric branching during metanephric kidney development Development, July 15, 2003; 130(14): 3175 - 3185. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Kinoshita, H. Iioka, A. Miyakoshi, and N. Ueno PKC{delta} is essential for Dishevelled function in a noncanonical Wnt pathway that regulates Xenopus convergent extension movements Genes & Dev., July 1, 2003; 17(13): 1663 - 1676. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Carron, A. Pascal, A. Djiane, J.-C. Boucaut, D.-L. Shi, and M. Umbhauer Frizzled receptor dimerization is sufficient to activate the Wnt/{beta}-catenin pathway J. Cell Sci., June 15, 2003; 116(12): 2541 - 2550. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. C. Sheldahl, D. C. Slusarski, P. Pandur, J. R. Miller, M. Kuhl, and R. T. Moon Dishevelled activates Ca2+ flux, PKC, and CamKII in vertebrate embryos J. Cell Biol., May 26, 2003; 161(4): 769 - 777. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Ohkawara, T. S. Yamamoto, M. Tada, and N. Ueno Role of glypican 4 in the regulation of convergent extension movements during gastrulation in Xenopus laevis Development, May 15, 2003; 130(10): 2129 - 2138. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Kwan and M. W. Kirschner Xbra functions as a switch between cell migration and convergent extension in the Xenopus gastrula Development, May 1, 2003; 130(9): 1961 - 1972. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Church, T. Nohno, C. Linker, C. Marcelle, and P. Francis-West Wnt regulation of chondrocyte differentiation J. Cell Sci., March 14, 2003; 115(24): 4809 - 4818. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Hikasa, M. Shibata, I. Hiratani, and M. Taira The Xenopus receptor tyrosine kinase Xror2 modulates morphogenetic movements of the axial mesoderm and neuroectoderm via Wnt signaling Development, March 13, 2003; 129(22): 5227 - 5239. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Howell, G. J. Inman, and C. S. Hill A novel Xenopus Smad-interacting forkhead transcription factor (XFast-3) cooperates with XFast-1 in regulating gastrulation movements Development, March 8, 2003; 129(12): 2823 - 2834. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Habas, I. B. Dawid, and X. He Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation Genes & Dev., January 15, 2003; 17(2): 295 - 309. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Keller Shaping the Vertebrate Body Plan by Polarized Embryonic Cell Movements Science, December 6, 2002; 298(5600): 1950 - 1954. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Schwarz-Romond, C. Asbrand, J. Bakkers, M. Kuhl, H.-J. Schaeffer, J. Huelsken, J. Behrens, M. Hammerschmidt, and W. Birchmeier The ankyrin repeat protein Diversin recruits Casein kinase Iepsilon to the beta -catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling Genes & Dev., August 15, 2002; 16(16): 2073 - 2084. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. N. Murdoch, K. Doudney, C. Paternotte, A. J. Copp, and P. Stanier Severe neural tube defects in the loop-tail mouse result from mutation of Lpp1, a novel gene involved in floor plate specification Hum. Mol. Genet., October 1, 2001; 10(22): 2593 - 2601. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Deardorff, C. Tan, J.-P. Saint-Jeannet, and P. S. Klein A role for frizzled 3 in neural crest development Development, October 1, 2001; 128(19): 3655 - 3663. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Tan, M. A. Deardorff, J.-P. Saint-Jeannet, J. Yang, A. Arzoumanian, and P. S. Klein Kermit, a frizzled interacting protein, regulates frizzled 3 signaling in neural crest development Development, October 1, 2001; 128(19): 3665 - 3674. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Nutt, K. S. Dingwell, C. E. Holt, and E. Amaya Xenopus Sprouty2 inhibits FGF-mediated gastrulation movements but does not affect mesoderm induction and patterning Genes & Dev., May 1, 2001; 15(9): 1152 - 1166. [Abstract] [Full Text]
|
|
