|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 127, Issue 15 3295-3303, Copyright © 2000 by Company of Biologists
JOURNAL ARTICLES |
B Jungblut and RJ Sommer
Max-Planck Institut fur Entwicklungsbiologie, Abt. Evolutionsbiologie, Spemannstrasse 37-39, D-72076 Tubingen, Germany.
Vulva development differs between Caenorhabditis elegans and Pristionchus pacificus in several ways. Seven of 12 ventral epidermal cells in P. pacificus die of apoptosis, whereas homologous cells in C. elegans fuse with the hypodermal syncytium. Vulva induction is a one-step process in C. elegans, but requires a continuous interaction between the gonad and the epidermis in P. pacificus. Here we describe several novel cell-cell interactions in P. pacificus, focusing on the vulva precursor cell P8.p and the mesoblast M. P8.p in P. pacificus, unlike its homologous cell in C. elegans, is incompetent to respond to gonadal signaling in the absence of other vulva precursor cells, but can respond to lateral signaling from a neighboring vulval precursor. P8.p provides an inhibitory signal that determines the developmental competence of P(5,7).p. This lateral inhibition acts via the mesoblast M and is regulated by the homeotic gene Ppa-mab-5. In Ppa-mab-5 mutants, M is misspecified and provides inductive signaling to the vulval precursor cells, including P8.p. Taken together, vulva development in P. pacificus displays novel cell-cell interactions involving the mesoblast M and P8.p. In particular, P8.p represents a new ventral epidermal cell type, which is characterized by novel interactions and a specific response to gonadal signaling.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  B. Yi and R. J. Sommer The pax-3 gene is involved in vulva formation in Pristionchus pacificus and is a target of the Hox gene lin-39 Development, September 1, 2007; 134(17): 3111 - 3119. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Zauner and R. J. Sommer Evolution of robustness in the signaling network of Pristionchus vulva development PNAS, June 12, 2007; 104(24): 10086 - 10091. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. K. Quigley, J. M. Turner, R. J. Nuckels, J. L. Manuel, E. H. Budi, E. L. MacDonald, and D. M. Parichy Pigment pattern evolution by differential deployment of neural crest and post-embryonic melanophore lineages in Danio fishes Development, December 15, 2004; 131(24): 6053 - 6069. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Gutierrez, L. Knoch, H. Witte, and R. J. Sommer Functional specificity of the nematode Hox gene mab-5 Development, March 1, 2003; 130(5): 983 - 993. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Jungblut, A. Pires-daSilva, and R. J. Sommer Formation of the egg-laying system in Pristionchus pacificus requires complex interactions between gonadal, mesodermal and epidermal tissues and does not rely on single cell inductions Development, September 15, 2001; 128(18): 3395 - 3404. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B Jungblut and R. Sommer The nematode even-skipped homolog vab-7 regulates gonad and vulva position in Pristionchus pacificus Development, January 1, 2001; 128(2): 253 - 261. [Abstract] [PDF]
|
|
