|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 127, Issue 15 3373-3383, Copyright © 2000 by Company of Biologists
JOURNAL ARTICLES |
A Zine, TR Van De Water and F de Ribaupierre
Institute of Physiology, University of Lausanne, Switzerland.
The development of the mammalian cochlea is an example of patterning in the peripheral nervous system. Sensory hair cells and supporting cells in the cochlea differentiate via regional and cell fate specification. The Notch signaling components shows both distinct and overlapping expression patterns of Notch1 receptor and its ligands Jagged1 (Jag1) and Jagged2 (Jag2) in the developing auditory epithelium of the rat. On embryonic day 16 (E16), many precursor cells within the Kolliker's organ immunostained for the presence of both Notch1 and Jag1, while the area of hair cell precursors did not express either Notch1 and Jag1. During initial events of hair cell differentiation between E18 and birth, Notch1 and Jag1 expression predominated in supporting cells and Jag2 in nascent hair cells. Early after birth, Jag2 expression decreased in hair cells while the pattern of Notch1 expression now included both supporting cells and hair cells. We show that the normal pattern of hair cell differentiation is disrupted by alteration of Notch signaling. A decrease of either Notch1 or Jag1 expression by antisense oligonucleotides in cultures of the developing sensory epithelium resulted in an increase in the number of hair cells. Our data suggest that the Notch1 signaling pathway is involved in a complex interplay between the consequences of different ligand-Notch1 combinations during cochlear morphogenesis and the phases of hair cell differentiation.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  E. Y. Ma, E. W Rubel, and D. W. Raible Notch Signaling Regulates the Extent of Hair Cell Regeneration in the Zebrafish Lateral Line J. Neurosci., February 27, 2008; 28(9): 2261 - 2273. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Daudet, L. Ariza-McNaughton, and J. Lewis Notch signalling is needed to maintain, but not to initiate, the formation of prosensory patches in the chick inner ear Development, June 15, 2007; 134(12): 2369 - 2378. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. B. Millimaki, E. M. Sweet, M. S. Dhason, and B. B. Riley Zebrafish atoh1 genes: classic proneural activity in the inner ear and regulation by Fgf and Notch Development, January 15, 2007; 134(2): 295 - 305. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. S. Tang, H. M. Alger, and F. A. Pereira COUP-TFI controls Notch regulation of hair cell and support cell differentiation Development, September 15, 2006; 133(18): 3683 - 3693. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Jones, M. Montcouquiol, A. Dabdoub, C. Woods, and M. W. Kelley Inhibitors of Differentiation and DNA Binding (Ids) Regulate Math1 and Hair Cell Formation during the Development of the Organ of Corti J. Neurosci., January 11, 2006; 26(2): 550 - 558. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. L. Hahn, J. Johnson, B. J. Beres, S. Howard, and J. Wilson-Rawls Lunatic fringe null female mice are infertile due to defects in meiotic maturation Development, February 15, 2005; 132(4): 817 - 828. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Daudet and J. Lewis Two contrasting roles for Notch activity in chick inner ear development: specification of prosensory patches and lateral inhibition of hair-cell differentiation Development, February 1, 2005; 132(3): 541 - 551. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Seta, T. Toyono, S. Kataoka, and K. Toyoshima Regulation of Taste Bud Cell Differentiation by Notch Signaling Pathway Chem Senses, January 1, 2005; 30(suppl_1): i48 - i49. [Full Text] [PDF]
|
|
|
|
 |
|
 R. D. Hawkins and M. Lovett The developmental genetics of auditory hair cells Hum. Mol. Genet., October 1, 2004; 13(suppl_2): R289 - R296. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. F. Stidworthy, S. Genoud, W.-W. Li, D. P. Leone, N. Mantei, U. Suter, and R. J. M. Franklin Notch1 and Jagged1 are expressed after CNS demyelination, but are not a major rate-determining factor during remyelination Brain, September 1, 2004; 127(9): 1928 - 1941. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Li, S. M. Price, H. Cahill, D. K. Ryugo, M. M. Shen, and M. Xiang Hearing loss caused by progressive degeneration of cochlear hair cells in mice deficient for the Barhl1 homeobox gene Development, March 9, 2003; 129(14): 3523 - 3532. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Chen, J. E. Johnson, H. Y. Zoghbi, and N. Segil The role of Math1 in inner ear development: Uncoupling the establishment of the sensory primordium from hair cell fate determination Development, March 7, 2003; 129(10): 2495 - 2505. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Bryant, R. J Goodyear, and G. P Richardson Sensory organ development in the inner ear: molecular and cellular mechanisms Br. Med. Bull., October 1, 2002; 63(1): 39 - 57. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Yan, N. Raben, and P. Plotz The Human Acid alpha -Glucosidase Gene Is a Novel Target of the Notch-1/Hes-1 Signaling Pathway J. Biol. Chem., August 9, 2002; 277(33): 29760 - 29764. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. N. Rivolta, A. Halsall, C. M. Johnson, M. A. Tones, and M. C. Holley Transcript Profiling of Functionally Related Groups of Genes During Conditional Differentiation of a Mammalian Cochlear Hair Cell Line Genome Res., July 1, 2002; 12(7): 1091 - 1099. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Zine, A. Aubert, J. Qiu, S. Therianos, F. Guillemot, R. Kageyama, and F. de Ribaupierre Hes1 and Hes5 Activities Are Required for the Normal Development of the Hair Cells in the Mammalian Inner Ear J. Neurosci., July 1, 2001; 21(13): 4712 - 4720. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Tsai, R. E. Hardisty, C. Rhodes, A. E. Kiernan, P. Roby, Z. Tymowska-Lalanne, P. Mburu, S. Rastan, A. J. Hunter, S. D. M. Brown, et al. The mouse slalom mutant demonstrates a role for Jagged1 in neuroepithelial patterning in the organ of Corti Hum. Mol. Genet., March 1, 2001; 10(5): 507 - 512. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Eddison, I. Le Roux, and J. Lewis Notch signaling in the development of the inner ear: Lessons from Drosophila PNAS, October 24, 2000; 97(22): 11692 - 11699. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Zheng, J Shou, F Guillemot, R Kageyama, and W. Gao Hes1 is a negative regulator of inner ear hair cell differentiation Development, January 11, 2000; 127(21): 4551 - 4560. [Abstract] [PDF]
|
|
|
|
|
|
A. E. Kiernan, N. Ahituv, H. Fuchs, R. Balling, K. B. Avraham, K. P. Steel, and M. Hrabe de Angelis The Notch ligand Jagged1 is required for inner ear sensory development PNAS, March 27, 2001; 98(7): 3873 - 3878. [Abstract] [Full Text] [PDF]
|
|
