spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Schwitzgebel, V. M.
Right arrow Articles by German, M. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Schwitzgebel, V. M.
Right arrow Articles by German, M. S.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Development, Vol 127, Issue 16 3533-3542, Copyright © 2000 by Company of Biologists

JOURNAL ARTICLES

Expression of neurogenin3 reveals an islet cell precursor population in the pancreas

VM Schwitzgebel, DW Scheel, JR Conners, J Kalamaras, JE Lee, DJ Anderson, L Sussel, JD Johnson and MS German
Hormone Research Institute, Department of Pediatrics, and Department of Medicine, University of California San Francisco, San Francisco, CA 94143, USA.

Differentiation of early gut endoderm cells into the endocrine cells forming the pancreatic islets of Langerhans depends on a cascade of gene activation events controlled by transcription factors including the basic helix-loop-helix (bHLH) proteins. To delineate this cascade, we began by establishing the position of neurogenin3, a bHLH factor found in the pancreas during fetal development. We detect neurogenin3 immunoreactivity transiently in scattered ductal cells in the fetal mouse pancreas, peaking at embryonic day 15.5. Although not detected in cells expressing islet hormones or the islet transcription factors Isl1, Brn4, Pax6 or PDX1, neurogenin3 is detected along with early islet differentiation factors Nkx6.1 and Nkx2.2, establishing that it is expressed in immature cells in the islet lineage. Analysis of transcription factor-deficient mice demonstrates that neurogenin3 expression is not dependent on neuroD1/BETA2, Mash1, Nkx2.2, Nkx6.1, or Pax6. Furthermore, early expression of neurogenin3 under control of the Pdx1 promoter is alone sufficient to drive early and ectopic differentiation of islet cells, a capability shared by the pancreatic bHLH factor, neuroD1/BETA2, but not by the muscle bHLH factor, MyoD. However, the islet cells produced in these transgenic experiments are overwhelmingly (alpha) cells, suggesting that factors other than the bHLH factors are required to deviate from a default * cell fate. These data support a model in which neurogenin3 acts upstream of other islet differentiation factors, initiating the differentiation of endocrine cells, but switching off prior to final differentiation. The ability to uniquely identify islet cell precursors by neurogenin3 expression allows us to determine the position of other islet transcription factors in the differentiation cascade and to propose a map for the islet cell differentiation pathway.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Proc. Natl. Acad. Sci. USAHome page
S. Wang, J. N. Jensen, P. A. Seymour, W. Hsu, Y. Dor, M. Sander, M. A. Magnuson, P. Serup, and G. Gu
Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function
PNAS, June 16, 2009; 106(24): 9715 - 9720.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
T. Guo and M. Hebrok
Stem Cells to Pancreatic {beta}-Cells: New Sources for Diabetes Cell Therapy
Endocr. Rev., May 1, 2009; 30(3): 214 - 227.
[Abstract] [Full Text] [PDF]

Home page
 Endocr Relat CancerHome page
Y.-C. Wang, E. Gallego-Arteche, G. Iezza, X. Yuan, M. R Matli, S.-P. Choo, M. B Zuraek, R. Gogia, F. C Lynn, M. S German, et al.
Homeodomain transcription factor NKX2.2 functions in immature cells to control enteroendocrine differentiation and is expressed in gastrointestinal neuroendocrine tumors
Endocr. Relat. Cancer, March 1, 2009; 16(1): 267 - 279.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Zhang, W.-D. Liu, N. A. Saunee, M. B. Breslin, and M. S. Lan
Zinc Finger Transcription Factor INSM1 Interrupts Cyclin D1 and CDK4 Binding and Induces Cell Cycle Arrest
J. Biol. Chem., February 27, 2009; 284(9): 5574 - 5581.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
A. S. Bernardo, C. H.-H. Cho, S. Mason, H. M. Docherty, R. A. Pedersen, L. Vallier, and K. Docherty
Biphasic Induction of Pdx1 in Mouse and Human Embryonic Stem Cells Can Mimic Development of Pancreatic {beta}-Cells
Stem Cells, February 1, 2009; 27(2): 341 - 351.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
N. Gao, J. LeLay, M. Z. Vatamaniuk, S. Rieck, J. R. Friedman, and K. H. Kaestner
Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development
Genes & Dev., December 15, 2008; 22(24): 3435 - 3448.
[Abstract] [Full Text] [PDF]

Home page
 Cold Spring Harb Symp Quant BiolHome page
Q. Zhou and D.A. Melton
Pathways to New {beta} Cells
Cold Spring Harb Symp Quant Biol, November 6, 2008; (2008) sqb.2008.72.002v1.
[Abstract] [PDF]

Home page
 Genes Dev.Home page
J. M. Oliver-Krasinski and D. A. Stoffers
On the origin of the {beta} cell
Genes & Dev., August 1, 2008; 22(15): 1998 - 2021.
[Abstract] [Full Text] [PDF]

Home page
 GENES CELLSHome page
T. Yoshida, N. Shiraki, H. Baba, M. Goto, S. Fujiwara, K. Kume, and S. Kume
Expression patterns of epiplakin1 in pancreas, pancreatic cancer and regenerating pancreas.
Genes Cells, July 1, 2008; 13(7): 667 - 678.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
N. Nekrep, J. Wang, T. Miyatsuka, and M. S. German
Signals from the neural crest regulate beta-cell mass in the pancreas
Development, June 15, 2008; 135(12): 2151 - 2160.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
P. White, C. Lee May, R. N. Lamounier, J. E. Brestelli, and K. H. Kaestner
Defining Pancreatic Endocrine Precursors and Their Descendants
Diabetes, March 1, 2008; 57(3): 654 - 668.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
M. Kodama, F. Takeshita, S. Kanegasaki, T. Ochiya, and G. Quinn
Pancreatic Endocrine and Exocrine Cell Ontogeny From Renal Capsule transplanted Embryonic Stem Cells in Streptozocin-injured Mice
J. Histochem. Cytochem., January 1, 2008; 56(1): 33 - 44.
[Abstract] [Full Text] [PDF]

Home page
 GENES CELLSHome page
H. Kokubu, T. Ohtsuka, and R. Kageyama
Mash1 is required for neuroendocrine cell development in the glandular stomach.
Genes Cells, January 1, 2008; 13(1): 41 - 51.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
I. Serafimidis, I. Rakatzi, V. Episkopou, M. Gouti, and A. Gavalas
Novel Effectors of Directed and Ngn3-Mediated Differentiation of Mouse Embryonic Stem Cells into Endocrine Pancreas Progenitors
Stem Cells, January 1, 2008; 26(1): 3 - 16.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
F. C. Lynn, P. Skewes-Cox, Y. Kosaka, M. T. McManus, B. D. Harfe, and M. S. German
MicroRNA Expression Is Required for Pancreatic Islet Cell Genesis in the Mouse
Diabetes, December 1, 2007; 56(12): 2938 - 2945.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
T. Masui, Q. Long, T. M. Beres, M. A. Magnuson, and R. J. MacDonald
Early pancreatic development requires the vertebrate Suppressor of Hairless (RBPJ) in the PTF1 bHLH complex
Genes & Dev., October 15, 2007; 21(20): 2629 - 2643.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
M. C. Jorgensen, J. Ahnfelt-Ronne, J. Hald, O. D. Madsen, P. Serup, and J. Hecksher-Sorensen
An Illustrated Review of Early Pancreas Development in the Mouse
Endocr. Rev., October 1, 2007; 28(6): 685 - 705.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
J. Ahnfelt-Ronne, M. C. Jorgensen, J. Hald, O. D. Madsen, P. Serup, and J. Hecksher-Sorensen
An Improved Method for Three-dimensional Reconstruction of Protein Expression Patterns in Intact Mouse and Chicken Embryos and Organs
J. Histochem. Cytochem., September 1, 2007; 55(9): 925 - 930.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
J. Jiang, M. Au, K. Lu, A. Eshpeter, G. Korbutt, G. Fisk, and A. S. Majumdar
Generation of Insulin-Producing Islet-Like Clusters from Human Embryonic Stem Cells
Stem Cells, August 1, 2007; 25(8): 1940 - 1953.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
S. B. Nelson, A. E. Schaffer, and M. Sander
The transcription factors Nkx6.1 and Nkx6.2 possess equivalent activities in promoting beta-cell fate specification in Pdx1+ pancreatic progenitor cells
Development, July 1, 2007; 134(13): 2491 - 2500.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
F. C. Lynn, S. B. Smith, M. E. Wilson, K. Y. Yang, N. Nekrep, and M. S. German
Sox9 coordinates a transcriptional network in pancreatic progenitor cells
PNAS, June 19, 2007; 104(25): 10500 - 10505.
[Abstract] [Full Text] [PDF]

Home page
 J Mol EndocrinolHome page
A. M Ackermann and M. Gannon
Molecular regulation of pancreatic {beta}-cell mass development, maintenance, and expansion
J. Mol. Endocrinol., February 1, 2007; 38(2): 193 - 206.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
J. Gromada, I. Franklin, and C. B. Wollheim
{alpha}-Cells of the Endocrine Pancreas: 35 Years of Research but the Enigma Remains
Endocr. Rev., February 1, 2007; 28(1): 84 - 116.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
L. C. Murtaugh
Pancreas and beta-cell development: from the actual to the possible
Development, February 1, 2007; 134(3): 427 - 438.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
T. Sugiyama, R. T. Rodriguez, G. W. McLean, and S. K. Kim
Conserved markers of fetal pancreatic epithelium permit prospective isolation of islet progenitor cells by FACS
PNAS, January 2, 2007; 104(1): 175 - 180.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
L. Vedtofte, T. B. Bodvarsdottir, A. E. Karlsen, and R. S. Heller
Developmental Biology of the Psammomys obesus Pancreas: Cloning and Expression of the Neurogenin-3 Gene
J. Histochem. Cytochem., January 1, 2007; 55(1): 97 - 104.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
E. Tweedie, I. Artner, L. Crawford, G. Poffenberger, B. Thorens, R. Stein, A. C. Powers, and M. Gannon
Maintenance of Hepatic Nuclear Factor 6 in Postnatal Islets Impairs Terminal Differentiation and Function of {beta}-Cells
Diabetes, December 1, 2006; 55(12): 3264 - 3270.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
T. Tayaramma, B. Ma, M. Rohde, and H. Mayer
Chromatin-Remodeling Factors Allow Differentiation of Bone Marrow Cells into Insulin-Producing Cells
Stem Cells, December 1, 2006; 24(12): 2858 - 2867.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
M. E Cerf
Transcription factors regulating {beta}-cell function.
Eur. J. Endocrinol., November 1, 2006; 155(5): 671 - 679.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
M. Mirasierra and M. Vallejo
The Homeoprotein Alx3 Expressed in Pancreatic ss-Cells Regulates Insulin Gene Transcription by Interacting with the Basic Helix-Loop-Helix Protein E47
Mol. Endocrinol., November 1, 2006; 20(11): 2876 - 2889.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
N. R. Treff, R. K. Vincent, M. L. Budde, V. L. Browning, J. F. Magliocca, V. Kapur, and J. S. Odorico
Differentiation of Embryonic Stem Cells Conditionally Expressing Neurogenin 3
Stem Cells, November 1, 2006; 24(11): 2529 - 2537.
[Abstract] [Full Text] [PDF]

Home page
 J Mol EndocrinolHome page
A. Petri, J. Ahnfelt-Ronne, K. S. Frederiksen, D. G. Edwards, D. Madsen, P. Serup, J. Fleckner, and R S. Heller
The effect of neurogenin3 deficiency on pancreatic gene expression in embryonic mice.
J. Mol. Endocrinol., October 1, 2006; 37(2): 301 - 316.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
M. S. Gierl, N. Karoulias, H. Wende, M. Strehle, and C. Birchmeier
The Zinc-finger factor Insm1 (IA-1) is essential for the development of pancreatic beta cells and intestinal endocrine cells
Genes & Dev., September 1, 2006; 20(17): 2465 - 2478.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
M. Ta, Y. Choi, F. Atouf, C. H. Park, and N. Lumelsky
The Defined Combination of Growth Factors Controls Generation of Long-Term-Replicating Islet Progenitor-Like Cells from Cultures of Adult Mouse Pancreas
Stem Cells, July 1, 2006; 24(7): 1738 - 1749.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
I. Artner, J. Le Lay, Y. Hang, L. Elghazi, J. C. Schisler, E. Henderson, B. Sosa-Pineda, and R. Stein
MafB: An Activator of the Glucagon Gene Expressed in Developing Islet {alpha}- and {beta}-Cells
Diabetes, February 1, 2006; 55(2): 297 - 304.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
C. S. Lee, D. D. De Leon, K. H. Kaestner, and D. A. Stoffers
Regeneration of Pancreatic Islets After Partial Pancreatectomy in Mice Does Not Involve the Reactivation of Neurogenin-3
Diabetes, February 1, 2006; 55(2): 269 - 272.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
M. E. Wilson, K. Y. Yang, A. Kalousova, J. Lau, Y. Kosaka, F. C. Lynn, J. Wang, C. Mrejen, V. Episkopou, H. C. Clevers, et al.
The HMG Box Transcription Factor Sox4 Contributes to the Development of the Endocrine Pancreas
Diabetes, December 1, 2005; 54(12): 3402 - 3409.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
G. K.C. Brolen, N. Heins, J. Edsbagge, and H. Semb
Signals From the Embryonic Mouse Pancreas Induce Differentiation of Human Embryonic Stem Cells Into Insulin-Producing {beta}-Cell-Like Cells
Diabetes, October 1, 2005; 54(10): 2867 - 2874.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
K. D. Henseleit, S. B. Nelson, K. Kuhlbrodt, J. C. Hennings, J. Ericson, and M. Sander
NKX6 transcription factor activity is required for {alpha}- and {beta}-cell development in the pancreas
Development, July 1, 2005; 132(13): 3139 - 3149.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
P. Collombat, J. Hecksher-Sorensen, V. Broccoli, J. Krull, I. Ponte, T. Mundiger, J. Smith, P. Gruss, P. Serup, and A. Mansouri
The simultaneous loss of Arx and Pax4 genes promotes a somatostatin-producing cell fate specification at the expense of the {alpha}- and {beta}-cell lineages in the mouse endocrine pancreas
Development, July 1, 2005; 132(13): 2969 - 2980.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. C. Schisler, P. B. Jensen, D. G. Taylor, T. C. Becker, F. K. Knop, S. Takekawa, M. German, G. C. Weir, D. Lu, R. G. Mirmira, et al.
The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells
PNAS, May 17, 2005; 102(20): 7297 - 7302.
[Abstract] [Full Text] [PDF]

Home page
 J Mol EndocrinolHome page
E Anastasi, C Santangelo, A Bulotta, F Dotta, B Argenti, C Mincione, A Gulino, M Maroder, R Perfetti, and U Di Mario
The acquisition of an insulin-secreting phenotype by HGF-treated rat pancreatic ductal cells (ARIP) is associated with the development of susceptibility to cytokine-induced apoptosis
J. Mol. Endocrinol., April 1, 2005; 34(2): 367 - 376.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
H. Kaneto, Y. Nakatani, T. Miyatsuka, T.-a. Matsuoka, M. Matsuhisa, M. Hori, and Y. Yamasaki
PDX-1/VP16 Fusion Protein, Together With NeuroD or Ngn3, Markedly Induces Insulin Gene Transcription and Ameliorates Glucose Tolerance
Diabetes, April 1, 2005; 54(4): 1009 - 1022.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
C. Moriscot, F. de Fraipont, M.-J. Richard, M. Marchand, P. Savatier, D. Bosco, M. Favrot, and P.-Y. Benhamou
Human Bone Marrow Mesenchymal Stem Cells Can Express Insulin and Key Transcription Factors of the Endocrine Pancreas Developmental Pathway upon Genetic and/or Microenvironmental Manipulation In Vitro
Stem Cells, April 1, 2005; 23(4): 594 - 603.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
J. Dominguez-Bendala, D. Klein, M. Ribeiro, C. Ricordi, L. Inverardi, R. Pastori, and H. Edlund
TAT-Mediated Neurogenin 3 Protein Transduction Stimulates Pancreatic Endocrine Differentiation In Vitro
Diabetes, March 1, 2005; 54(3): 720 - 726.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
E. B. Harmon, A. A. Apelqvist, N. G. Smart, X. Gu, D. H. Osborne, and S. K. Kim
GDF11 modulates NGN3+ islet progenitor cell number and promotes {beta}-cell differentiation in pancreas development
Development, December 15, 2004; 131(24): 6163 - 6174.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
L.-Z. Cao, D.-Q. Tang, M. E. Horb, S.-W. Li, and L.-J. Yang
High Glucose Is Necessary for Complete Maturation of Pdx1-VP16-Expressing Hepatic Cells into Functional Insulin-Producing Cells
Diabetes, December 1, 2004; 53(12): 3168 - 3178.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
G. Mellitzer, M. Martin, M. Sidhoum-Jenny, C. Orvain, J. Barths, P. A. Seymour, M. Sander, and G. Gradwohl
Pancreatic Islet Progenitor Cells in Neurogenin 3-Yellow Fluorescent Protein Knock-Add-On Mice
Mol. Endocrinol., November 1, 2004; 18(11): 2765 - 2776.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
Y. Choi, M. Ta, F. Atouf, and N. Lumelsky
Adult Pancreas Generates Multipotent Stem Cells and Pancreatic and Nonpancreatic Progeny
Stem Cells, November 1, 2004; 22(6): 1070 - 1084.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
T. Ogata, L. Li, S. Yamada, Y. Yamamoto, Y. Tanaka, I. Takei, K. Umezawa, and I. Kojima
Promotion of {beta}-Cell Differentiation by Conophylline in Fetal and Neonatal Rat Pancreas
Diabetes, October 1, 2004; 53(10): 2596 - 2602.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
M. Hansson, A. Tonning, U. Frandsen, A. Petri, J. Rajagopal, M. C.O. Englund, R. S. Heller, J. Hakansson, J. Fleckner, H. N. Skold, et al.
Artifactual Insulin Release From Differentiated Embryonic Stem Cells
Diabetes, October 1, 2004; 53(10): 2603 - 2609.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
R. Gasa, C. Mrejen, N. Leachman, M. Otten, M. Barnes, J. Wang, S. Chakrabarti, R. Mirmira, and M. German
Proendocrine genes coordinate the pancreatic islet differentiation program in vitro
PNAS, September 7, 2004; 101(36): 13245 - 13250.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S. E. Schonhoff, M. Giel-Moloney, and A. B. Leiter
Minireview: Development and Differentiation of Gut Endocrine Cells
Endocrinology, June 1, 2004; 145(6): 2639 - 2644.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
L. Zhu, T. Tran, J. M. Rukstalis, P. Sun, B. Damsz, and S. F. Konieczny
Inhibition of Mist1 Homodimer Formation Induces Pancreatic Acinar-to-Ductal Metaplasia
Mol. Cell. Biol., April 1, 2004; 24(7): 2673 - 2681.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
B. Lamolet, G. Poulin, K. Chu, F. Guillemot, M.-J. Tsai, and J. Drouin
Tpit-Independent Function of NeuroD1(BETA2) in Pituitary Corticotroph Differentiation
Mol. Endocrinol., April 1, 2004; 18(4): 995 - 1003.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
H. Yoshitomi and K. S. Zaret
Endothelial cell interactions initiate dorsal pancreas development by selectively inducing the transcription factor Ptf1a
Development, February 15, 2004; 131(4): 807 - 817.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
R. Bort, J. P. Martinez-Barbera, R. S. P. Beddington, and K. S. Zaret
Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas
Development, February 15, 2004; 131(4): 797 - 806.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
S. B. Smith, H. Watada, and M. S. German
Neurogenin3 Activates the Islet Differentiation Program while Repressing Its Own Expression
Mol. Endocrinol., January 1, 2004; 18(1): 142 - 149.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
G. Gu, J. M. Wells, D. Dombkowski, F. Preffer, B. Aronow, and D. A. Melton
Global expression analysis of gene regulatory pathways during endocrine pancreatic development
Development, January 1, 2004; 131(1): 165 - 179.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
M. A. Maestro, S. F. Boj, R. F. Luco, C. E. Pierreux, J. Cabedo, J. M. Servitja, M. S. German, G. G. Rousseau, F. P. Lemaigre, and J. Ferrer
Hnf6 and Tcf2 (MODY5) are linked in a gene network operating in a precursor cell domain of the embryonic pancreas
Hum. Mol. Genet., December 15, 2003; 12(24): 3307 - 3314.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
B. C. Lewis, D. S. Klimstra, and H. E. Varmus
The c-myc and PyMT oncogenes induce different tumor types in a somatic mouse model for pancreatic cancer
Genes & Dev., December 15, 2003; 17(24): 3127 - 3138.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
L. C. Murtaugh, B. Z. Stanger, K. M. Kwan, and D. A. Melton
Notch signaling controls multiple steps of pancreatic differentiation
PNAS, December 9, 2003; 100(25): 14920 - 14925.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
P. Collombat, A. Mansouri, J. Hecksher-Sorensen, P. Serup, J. Krull, G. Gradwohl, and P. Gruss
Opposing actions of Arx and Pax4 in endocrine pancreas development
Genes & Dev., October 15, 2003; 17(20): 2591 - 2603.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. B. Smith, R. Gasa, H. Watada, J. Wang, S. C. Griffen, and M. S. German
Neurogenin3 and Hepatic Nuclear Factor 1 Cooperate in Activating Pancreatic Expression of Pax4
J. Biol. Chem., October 3, 2003; 278(40): 38254 - 38259.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
K. H. Kaestner, C. S. Lee, L. M. Scearce, J. E. Brestelli, A. Arsenlis, P. P. Le, K. A. Lantz, J. Crabtree, A. Pizarro, J. Mazzarelli, et al.
Transcriptional Program of the Endocrine Pancreas in Mice and Humans
Diabetes, July 1, 2003; 52(7): 1604 - 1610.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. A. Hardikar, B. Marcus-Samuels, E. Geras-Raaka, B. M. Raaka, and M. C. Gershengorn
Human pancreatic precursor cells secrete FGF2 to stimulate clustering into hormone-expressing islet-like cell aggregates
PNAS, June 10, 2003; 100(12): 7117 - 7122.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Ogihara, H. Watada, R. Kanno, F. Ikeda, T. Nomiyama, Y. Tanaka, A. Nakao, M. S. German, I. Kojima, and R. Kawamori
p38 MAPK Is Involved in Activin A- and Hepatocyte Growth Factor-mediated Expression of Pro-endocrine Gene Neurogenin 3 in AR42J-B13 Cells
J. Biol. Chem., June 6, 2003; 278(24): 21693 - 21700.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. Watada, D. W. Scheel, J. Leung, and M. S. German
Distinct Gene Expression Programs Function in Progenitor and Mature Islet Cells
J. Biol. Chem., May 2, 2003; 278(19): 17130 - 17140.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
G. Gu, J. Dubauskaite, and D. A. Melton
Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors
Development, March 7, 2003; 129(10): 2447 - 2457.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
P. Blyszczuk, J. Czyz, G. Kania, M. Wagner, U. Roll, L. St-Onge, and A. M. Wobus
Expression of Pax4 in embryonic stem cells promotes differentiation of nestin-positive progenitor and insulin-producing cells
PNAS, February 4, 2003; 100(3): 998 - 1003.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. R. Laybutt, M. Glandt, G. Xu, Y. B. Ahn, N. Trivedi, S. Bonner-Weir, and G. C. Weir
Critical Reduction in beta -Cell Mass Results in Two Distinct Outcomes over Time. ADAPTATION WITH IMPAIRED GLUCOSE TOLERANCE OR DECOMPENSATED DIABETES
J. Biol. Chem., January 24, 2003; 278(5): 2997 - 3005.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
Y. Heremans, M. Van De Casteele, P. in't Veld, G. Gradwohl, P. Serup, O. Madsen, D. Pipeleers, and H. Heimberg
Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3
J. Cell Biol., October 28, 2002; 159(2): 303 - 312.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
C. Demeterco, P. Itkin-Ansari, B. Tyrberg, L. P. Ford, R. A. Jarvis, and F. Levine
c-Myc Controls Proliferation Versus Differentiation in Human Pancreatic Endocrine Cells
J. Clin. Endocrinol. Metab., July 1, 2002; 87(7): 3475 - 3485.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
J.-W. Kim, V. Seghers, J.-H. Cho, Y. Kang, S. Kim, Y. Ryu, K. Baek, L. Aguilar-Bryan, Y.-D. Lee, J. Bryan, et al.
Transactivation of the Mouse Sulfonylurea Receptor I Gene by BETA2/NeuroD
Mol. Endocrinol., May 1, 2002; 16(5): 1097 - 1107.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. K. Chakrabarti, J. C. James, and R. G. Mirmira
Quantitative Assessment of Gene Targeting in Vitro and in Vivo by the Pancreatic Transcription Factor, Pdx1. IMPORTANCE OF CHROMATIN STRUCTURE IN DIRECTING PROMOTER BINDING
J. Biol. Chem., April 5, 2002; 277(15): 13286 - 13293.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
M. B. Breslin, M. Zhu, A. L. Notkins, and M. S. Lan
Neuroendocrine differentiation factor, IA-1, is a transcriptional repressor and contains a specific DNA-binding domain: identification of consensus IA-1 binding sequence
Nucleic Acids Res., February 15, 2002; 30(4): 1038 - 1045.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
A. Bhushan, N. Itoh, S. Kato, J. P. Thiery, P. Czernichow, S. Bellusci, and R. Scharfmann
Fgf10 is essential for maintaining the proliferative capacity of epithelial progenitor cells during early pancreatic organogenesis
Development, December 15, 2001; 128(24): 5109 - 5117.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
C. L. Pin, J. M. Rukstalis, C. Johnson, and S. F. Konieczny
The bHLH transcription factor Mist1 is required to maintain exocrine pancreas cell organization and acinar cell identity
J. Cell Biol., November 12, 2001; 155(4): 519 - 530.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
A. Abderrahmani, M. Steinmann, V. Plaisance, G. Niederhauser, J.-A. Haefliger, V. Mooser, C. Bonny, P. Nicod, and G. Waeber
The Transcriptional Repressor REST Determines the Cell-Specific Expression of the Human MAPK8IP1 Gene Encoding IB1 (JIP-1)
Mol. Cell. Biol., November 1, 2001; 21(21): 7256 - 7267.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
S. Assady, G. Maor, M. Amit, J. Itskovitz-Eldor, K. L. Skorecki, and M. Tzukerman
Insulin Production by Human Embryonic Stem Cells
Diabetes, August 1, 2001; 50(8): 1691 - 1697.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
J. C. Lee, S. B. Smith, H. Watada, J. Lin, D. Scheel, J. Wang, R. G. Mirmira, and M. S. German
Regulation of the Pancreatic Pro-Endocrine Gene Neurogenin3
Diabetes, May 1, 2001; 50(5): 928 - 936.
[Abstract] [Full Text]

Home page
 DiabetesHome page
L. del Bosque-Plata, J. Lin, Y. Horikawa, P. E.H. Schwarz, N. J. Cox, N. Iwasaki, M. Ogata, Y. Iwamoto, M. S. German, and G. I. Bell
Mutations in the Coding Region of the Neurogenin 3 Gene (NEUROG3) Are Not a Common Cause of Maturity-Onset Diabetes of the Young in Japanese Subjects
Diabetes, March 1, 2001; 50(3): 694 - 696.
[Abstract] [Full Text]

Home page
 Genes Dev.Home page
A. Grapin-Botton, A. R. Majithia, and D. A. Melton
Key events of pancreas formation are triggered in gut endoderm by ectopic expression of pancreatic regulatory genes
Genes & Dev., February 15, 2001; 15(4): 444 - 454.
[Abstract] [Full Text]

Home page
 Genes Dev.Home page
S. K. Kim and M. Hebrok
Intercellular signals regulating pancreas development and function
Genes & Dev., January 15, 2001; 15(2): 111 - 127.
[Full Text]

Home page
 DevelopmentHome page
M Sander, L Sussel, J Conners, D Scheel, J Kalamaras, F Dela Cruz, V Schwitzgebel, A Hayes-Jordan, and M German
Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas
Development, January 12, 2000; 127(24): 5533 - 5540.
[Abstract] [PDF]

Home page
 ScienceHome page
N. Lumelsky, O. Blondel, P. Laeng, I. Velasco, R. Ravin, and R. McKay
Differentiation of Embryonic Stem Cells to Insulin-Secreting Structures Similar to Pancreatic Islets
Science, May 18, 2001; 292(5520): 1389 - 1394.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
H. Watada, R. G. Mirmira, J. Leung, and M. S. German
Transcriptional and Translational Regulation of beta -Cell Differentiation Factor Nkx6.1
J. Biol. Chem., October 27, 2000; 275(44): 34224 - 34230.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. B. Smith, H. Watada, D. W. Scheel, C. Mrejen, and M. S. German
Autoregulation and Maturity Onset Diabetes of the Young Transcription Factors Control the Human PAX4 Promoter
J. Biol. Chem., November 17, 2000; 275(47): 36910 - 36919.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. Wang, P. Maechler, B. Ritz-Laser, K. A. Hagenfeldt, H. Ishihara, J. Philippe, and C. B. Wollheim
Pdx1 Level Defines Pancreatic Gene Expression Pattern and Cell Lineage Differentiation
J. Biol. Chem., June 29, 2001; 276(27): 25279 - 25286.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2000