spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Rawls, J. F.
Right arrow Articles by Johnson, S. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rawls, J. F.
Right arrow Articles by Johnson, S. L.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Development, Vol 127, Issue 17 3715-3724, Copyright © 2000 by Company of Biologists

JOURNAL ARTICLES

Zebrafish kit mutation reveals primary and secondary regulation of melanocyte development during fin stripe regeneration

JF Rawls and SL Johnson
Department of Genetics, Box 8232, Washington University School of Medicine, St Louis, MO 63110, USA.

Fin regeneration in adult zebrafish is accompanied by re-establishment of the pigment stripes. To understand the mechanisms underlying fin stripe regeneration and regulation of normal melanocyte stripe morphology, we investigated the origins of melanocytes in the regenerating fin and their requirement for the kit receptor tyrosine kinase. Using pre-existing melanin as a lineage tracer, we show that most fin regeneration melanocytes develop from undifferentiated precursors, rather than from differentiated melanocytes. Mutational analysis reveals two distinct classes of regeneration melanocytes. First, an early regeneration class develops dependent on kit function. In the absence of kit function and kit-dependent melanocytes, a second class of melanocytes develops at later stages of regeneration. This late kit-independent class of regeneration melanocytes has little or no role in wild-type fin stripe development, thus revealing a secondary mode for regulation of fin stripes. Expression of melanocyte markers in regenerating kit mutant fins suggests that kit normally acts after mitf and before dct to promote development of the primary kit-dependent melanocytes. kit-dependent and kit-independent melanocytes are also present during fin stripe ontogeny in patterns similar to those observed during regeneration.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 DevelopmentHome page
E. H. Budi, L. B. Patterson, and D. M. Parichy
Embryonic requirements for ErbB signaling in neural crest development and adult pigment pattern formation
Development, August 1, 2008; 135(15): 2603 - 2614.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Yamaguchi, E. Yoshimoto, and S. Kondo
Pattern regulation in the stripe of zebrafish suggests an underlying dynamic and autonomous mechanism
PNAS, March 20, 2007; 104(12): 4790 - 4793.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. G. Mills, R. J. Nuckels, and D. M. Parichy
Deconstructing evolution of adult phenotypes: genetic analyses of kit reveal homology and evolutionary novelty during adult pigment pattern development of Danio fishes
Development, March 15, 2007; 134(6): 1081 - 1090.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
C.-T. Yang and S. L. Johnson
Small molecule-induced ablation and subsequent regeneration of larval zebrafish melanocytes
Development, September 15, 2006; 133(18): 3563 - 3573.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
I. K. Quigley, J. M. Turner, R. J. Nuckels, J. L. Manuel, E. H. Budi, E. L. MacDonald, and D. M. Parichy
Pigment pattern evolution by differential deployment of neural crest and post-embryonic melanophore lineages in Danio fishes
Development, December 15, 2004; 131(24): 6053 - 6069.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
J. M. Zodrow and R. L. Tanguay
2,3,7,8-Tetrachlorodibenzo-p-dioxin Inhibits Zebrafish Caudal Fin Regeneration
Toxicol. Sci., November 1, 2003; 76(1): 151 - 161.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
D. M. Parichy and J. M. Turner
Temporal and cellular requirements for Fms signaling during zebrafish adult pigment pattern development
Development, March 1, 2003; 130(5): 817 - 833.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol PatholHome page
J. M. Spitsbergen and M. L. Kent
The State of the Art of the Zebrafish Model for Toxicology and Toxicologic Pathology Research--Advantages and Current Limitations
Toxicol Pathol, January 1, 2003; 31(1_suppl): 62 - 87.
[Abstract] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
E. Quint, A. Smith, F. Avaron, L. Laforest, J. Miles, W. Gaffield, and M.-A. Akimenko
From the Cover: Bone patterning is altered in the regenerating zebrafish caudal fin after ectopic expression of sonic hedgehog and bmp2b or exposure to cyclopamine
PNAS, June 25, 2002; 99(13): 8713 - 8718.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
A. Nechiporuk and M. T. Keating
A proliferation gradient between proximal and msxb-expressing distal blastema directs zebrafish fin regeneration
Development, January 6, 2002; 129(11): 2607 - 2617.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2000