|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 127, Issue 18 4049-4060, Copyright © 2000 by Company of Biologists
JOURNAL ARTICLES |
DS Fay and M Han
Howard Hughes Medical Institute and Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder CO 80309-0347, USA. fayd@alpha.colorado.edu
We have identified strong loss-of-function mutations in the C. elegans cyclin E gene, cye-1. Mutations in cye-1 lead to the underproliferation of many postembryonic blast lineages as well as defects in fertility and gut-cell endoreduplication. In addition, cye-1 is required maternally, but not zygotically for embryonic development. Our analysis of vulval development in cye-1 mutants suggests that a timing mechanism may control the onset of vulval cell terminal differentiation: once induced, these cells appear to differentiate after a set amount of time, rather than a specific number of division cycles. cye-1 mutants also show an increase in the percentage of vulval precursor cells (VPCs) that adopt vulval cell fates, indicating that cell-cycle length can play a role in the proper patterning of vulval cells. By analyzing cul-1 mutants, we further demonstrate that vulval cell terminal differentiation can be uncoupled from associated changes in vulval cell division planes.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  Y. Budirahardja and P. Gonczy Coupling the cell cycle to development Development, September 1, 2009; 136(17): 2861 - 2872. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Dorsett, B. Westlund, and T. Schedl METT-10, A Putative Methyltransferase, Inhibits Germ Cell Proliferative Fate in Caenorhabditis elegans Genetics, September 1, 2009; 183(1): 233 - 247. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Margalit, E. Neufeld, N. Feinstein, K. L. Wilson, B. Podbilewicz, and Y. Gruenbaum Barrier to autointegration factor blocks premature cell fusion and maintains adult muscle integrity in C. elegans J. Cell Biol., August 9, 2007; 178(4): 661 - 673. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Kim and E. T. Kipreos The Caenorhabditis elegans Replication Licensing Factor CDT-1 Is Targeted for Degradation by the CUL-4/DDB-1 Complex Mol. Cell. Biol., February 15, 2007; 27(4): 1394 - 1406. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Y. Kim and R. Roy Cell cycle regulators control centrosome elimination during oogenesis in Caenorhabditis elegans J. Cell Biol., September 11, 2006; 174(6): 751 - 757. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Grishok and P. A. Sharp Negative regulation of nuclear divisions in Caenorhabditis elegans by retinoblastoma and RNA interference-related genes PNAS, November 29, 2005; 102(48): 17360 - 17365. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Jiang, V. Horner, and J. Liu The HMX homeodomain protein MLS-2 regulates cleavage orientation, cell proliferation and cell fate specification in the C. elegans postembryonic mesoderm Development, September 15, 2005; 132(18): 4119 - 4130. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Artus, S. Vandormael-Pournin, M. Frodin, K. Nacerddine, C. Babinet, and M. Cohen-Tannoudji Impaired Mitotic Progression and Preimplantation Lethality in Mice Lacking OMCG1, a New Evolutionarily Conserved Nuclear Protein Mol. Cell. Biol., July 15, 2005; 25(14): 6289 - 6302. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. T. Su and J. Stumpff Promiscuity Rules? The Dispensability of Cyclin E and Cdk2 Sci. Signal., March 16, 2004; 2004(224): pe11 - pe11. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. M. Yeong Anaphase-Promoting Complex in Caenorhabditis elegans Mol. Cell. Biol., March 15, 2004; 24(6): 2215 - 2225. [Full Text] [PDF]
|
|
|
|
|
|
F. Wang, J. Yoder, I. Antoshechkin, and M. Han Caenorhabditis elegans EVL-14/PDS-5 and SCC-3 Are Essential for Sister Chromatid Cohesion in Meiosis and Mitosis Mol. Cell. Biol., November 1, 2003; 23(21): 7698 - 7707. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. C. Shakes, P. L. Sadler, J. M. Schumacher, M. Abdolrasulnia, and A. Golden Developmental defects observed in hypomorphic anaphase-promoting complex mutants are linked to cell cycle abnormalities Development, April 15, 2003; 130(8): 1605 - 1620. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Suzuki, G. A. Morris, M. Han, and W. B. Wood A Cuticle Collagen Encoded by the lon-3 Gene May Be a Target of TGF-{beta} Signaling in Determining Caenorhabditis elegans Body Shape Genetics, December 1, 2002; 162(4): 1631 - 1639. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Li, J. C. Ruiz, and K. T. Chun CUL-4A Is Critical for Early Embryonic Development Mol. Cell. Biol., July 15, 2002; 22(14): 4997 - 5005. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Kostic and R. Roy Organ-specific cell division abnormalities caused by mutation in a general cell cycle regulator in C. elegans Development, January 5, 2002; 129(9): 2155 - 2165. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Boxem and S. van den Heuvel lin-35 Rb and cki-1 Cip/Kip cooperate in developmental regulation of G1 progression in C. elegans Development, November 1, 2001; 128(21): 4349 - 4359. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. H. Yoder and M. Han Cytoplasmic Dynein Light Intermediate Chain Is Required for Discrete Aspects of Mitosis in Caenorhabditis elegans Mol. Biol. Cell, October 1, 2001; 12(10): 2921 - 2933. [Abstract] [Full Text] [PDF]
|
|
