|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 127, Issue 19 4265-4275, Copyright © 2000 by Company of Biologists
JOURNAL ARTICLES |
JL Nowicki and AC Burke
University of North Carolina, Department of Biology, Chapel Hill, NC 27599, USA.
The successful organization of the vertebrate body requires that local information in the embryo be translated into a functional, global pattern. Somite cells form the bulk of the musculoskeletal system. Heterotopic transplants of segmental plate along the axis from quail to chick were performed to test the correlation between autonomous morphological patterning and Hox gene expression in somite subpopulations. The data presented strengthen the correlation of Hox gene expression with axial specification and focus on the significance of Hox genes in specific derivatives of the somites. We have defined two anatomical compartments of the body based on the embryonic origin of the cells making up contributing structures: the dorsal compartment, formed from purely somitic cell populations; and the ventral compartment comprising cells from somites and lateral plate. The boundary between these anatomical compartments is termed the somitic frontier. Somitic tissue transplanted between axial levels retains both original Hox expression and morphological identity in the dorsal compartment. In contrast, migrating lateral somitic cells crossing the somitic frontier do not maintain donor Hox expression but apparently adopt the Hox expression of the lateral plate and participate in the morphology appropriate to the host level. Dorsal and ventral compartments, as defined here, have relevance for experimental manipulations that influence somite cell behavior. The correlation of Hox expression profiles and patterning behavior of cells in these two compartments supports the hypothesis of independent Hox codes in paraxial and lateral plate mesoderm.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  M. J. McGrew, A. Sherman, S. G. Lillico, F. M. Ellard, P. A. Radcliffe, H. J. Gilhooley, K. A. Mitrophanous, N. Cambray, V. Wilson, and H. Sang Localised axial progenitor cell populations in the avian tail bud are not committed to a posterior Hox identity Development, July 1, 2008; 135(13): 2289 - 2299. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. C. McIntyre, S. Rakshit, A. R. Yallowitz, L. Loken, L. Jeannotte, M. R. Capecchi, and D. M. Wellik Hox patterning of the vertebrate rib cage Development, August 15, 2007; 134(16): 2981 - 2989. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Pilon, K. Oh, J.-R. Sylvestre, J. G. A. Savory, and D. Lohnes Wnt signaling is a key mediator of Cdx1 expression in vivo Development, June 15, 2007; 134(12): 2315 - 2323. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Nagashima, S. Kuraku, K. Uchida, Y. K. Ohya, Y. Narita, and S. Kuratani On the carapacial ridge in turtle embryos: its developmental origin, function and the chelonian body plan Development, June 15, 2007; 134(12): 2219 - 2226. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Bolos, J. Grego-Bessa, and J. L. de la Pompa Notch Signaling in Development and Cancer Endocr. Rev., May 1, 2007; 28(3): 339 - 363. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. S. Thimgan, J. S. Berg, and A. E. Stuart Comparative sequence analysis and tissue localization of members of the SLC6 family of transporters in adult Drosophila melanogaster J. Exp. Biol., September 1, 2006; 209(17): 3383 - 3404. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Park, Y. J. Lee, H.-J. Lee, T. Seki, K.-H. Hong, J. Park, H. Beppu, I. K. Lim, J.-W. Yoon, E. Li, et al. B-Cell Translocation Gene 2 (Btg2) Regulates Vertebral Patterning by Modulating Bone Morphogenetic Protein/Smad Signaling Mol. Cell. Biol., December 1, 2004; 24(23): 10256 - 10262. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Dubrulle and O. Pourquie Coupling segmentation to axis formation Development, December 1, 2004; 131(23): 5783 - 5793. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Beland, N. Pilon, M. Houle, K. Oh, J.-R. Sylvestre, P. Prinos, and D. Lohnes Cdx1 Autoregulation Is Governed by a Novel Cdx1-LEF1 Transcription Complex Mol. Cell. Biol., June 1, 2004; 24(11): 5028 - 5038. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Houle, J.-R. Sylvestre, and D. Lohnes Retinoic acid regulates a subset of Cdx1 function in vivo Development, December 29, 2003; 130(26): 6555 - 6567. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. M. Wellik and M. R. Capecchi Hox10 and Hox11 Genes Are Required to Globally Pattern the Mammalian Skeleton Science, July 18, 2003; 301(5631): 363 - 367. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. C. Burke and J. L. Nowicki Hox Genes and Axial Specification in Vertebrates Integr. Comp. Biol., June 1, 2001; 41(3): 687 - 697. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Ordahl, E Berdougo, S. Venters, and W. Denetclaw The dermomyotome dorsomedial lip drives growth and morphogenesis of both the primary myotome and dermomyotome epithelium Development, January 5, 2001; 128(10): 1731 - 1744. [Abstract] [PDF]
|
|
