|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 127, Issue 20 4407-4417, Copyright © 2000 by Company of Biologists
JOURNAL ARTICLES |
M Llimargas
Medical Research Council-Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK. mlc@mrc-lmb.cam.ac.uk
The Drosophila tracheal tree consists of a tubular network of epithelial branches that constitutes the respiratory system. Groups of tracheal cells migrate towards stereotyped directions while they acquire specific tracheal fates. This work shows that the wingless/WNT signalling pathway is needed within the tracheal cells for the formation of the dorsal trunk and for fusion of the branches. These functions are achieved through the regulation of target genes, such as spalt in the dorsal trunk and escargot in the fusion cells. The pathway also aids tracheal invagination and helps guide the ganglionic branch. Moreover the wingless/WNT pathway displays antagonistic interactions with the DPP (decapentaplegic) pathway, which regulates branching along the dorsoventral axis. Remarkably, the wingless gene itself, acting through its canonical pathway, seems not to be absolutely required for all these tracheal functions. However, the artificial overexpression of wingless in tracheal cells mimics the overexpression of a constitutively activated armadillo protein. The results suggest that another gene product, possibly a WNT, could help to trigger the wingless cascade in the developing tracheae.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  M. Shindo, H. Wada, M. Kaido, M. Tateno, T. Aigaki, L. Tsuda, and S. Hayashi Dual function of Src in the maintenance of adherens junctions during tracheal epithelial morphogenesis Development, April 1, 2008; 135(7): 1355 - 1364. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Araujo, C. Cela, and M. Llimargas Tramtrack regulates different morphogenetic events during Drosophila tracheal development Development, October 15, 2007; 134(20): 3665 - 3676. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Ma, W. Cui, J. Yang, J. Qu, C. Di, H. M. Amin, R. Lai, J. Ritz, D. S. Krause, and L. Chai SALL4, a novel oncogene, is constitutively expressed in human acute myeloid leukemia (AML) and induces AML in transgenic mice Blood, October 15, 2006; 108(8): 2726 - 2735. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Brodu and J. Casanova The RhoGAP crossveinless-c links trachealess and EGFR signaling to cell shape remodeling in Drosophila tracheal invagination. Genes & Dev., July 1, 2006; 20(13): 1817 - 1828. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Matusek, A. Djiane, F. Jankovics, D. Brunner, M. Mlodzik, and J. Mihaly The Drosophila formin DAAM regulates the tracheal cuticle pattern through organizing the actin cytoskeleton Development, March 1, 2006; 133(5): 957 - 966. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Tonning, S. Helms, H. Schwarz, A. E. Uv, and B. Moussian Hormonal regulation of mummy is needed for apical extracellular matrix formation and epithelial morphogenesis in Drosophila Development, January 15, 2006; 133(2): 331 - 341. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Cabernard, M. Neumann, and M. Affolter Cellular and molecular mechanisms involved in branching morphogenesis of the Drosophila tracheal system J Appl Physiol, December 1, 2004; 97(6): 2347 - 2353. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kato, T. Chihara, and S. Hayashi Hedgehog and Decapentaplegic instruct polarized growth of cell extensions in the Drosophila trachea Development, November 1, 2004; 131(21): 5253 - 5261. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Song and T. Xie wingless signaling regulates the maintenance of ovarian somatic stem cells in Drosophila Development, July 15, 2003; 130(14): 3259 - 3268. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Chihara, K. Kato, M. Taniguchi, J. Ng, and S. Hayashi Rac promotes epithelial cell rearrangement during tracheal tubulogenesis in Drosophila Development, April 1, 2003; 130(7): 1419 - 1428. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Dorfman, L. Glazer, U. Weihe, M. F. Wernet, and B.-Z. Shilo Elbow and Noc define a family of zinc finger proteins controlling morphogenesis of specific tracheal branches Development, August 1, 2002; 129(15): 3585 - 3596. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Sedaghat, W. F. Miranda, and M. J. Sonnenfeld The jing Zn-finger transcription factor is a mediator of cellular differentiation in the Drosophila CNS midline and trachea Development, January 6, 2002; 129(11): 2591 - 2606. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Llimargas and P. A. Lawrence Seven Wnt homologues in Drosophila: A case study of the developing tracheae PNAS, November 15, 2001; (2001) 251304398. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Nishinakamura, Y. Matsumoto, K. Nakao, K. Nakamura, A. Sato, N. G. Copeland, D. J. Gilbert, N. A. Jenkins, S. Scully, D. L. Lacey, et al. Murine homolog of SALL1 is essential for ureteric bud invasion in kidney development Development, August 15, 2001; 128(16): 3105 - 3115. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Boube, M. D. Martin-Bermudo, N. H. Brown, and J. Casanova Specific tracheal migration is mediated by complementary expression of cell surface proteins Genes & Dev., June 15, 2001; 15(12): 1554 - 1562. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L Glazer and B. Shilo Hedgehog signaling patterns the tracheal branches Development, January 5, 2001; 128(9): 1599 - 1606. [Abstract] [PDF]
|
|
|
|
|
|
M. Llimargas and P. A. Lawrence Seven Wnt homologues in Drosophila: A case study of the developing tracheae PNAS, December 4, 2001; 98(25): 14487 - 14492. [Abstract] [Full Text] [PDF]
|
|
