|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 127, Issue 21 4655-4668, Copyright © 2000 by Company of Biologists
JOURNAL ARTICLES |
L Honigberg and C Kenyon
Program in Neuroscience and Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143-0448, USA.
The bilateral C. elegans neuroblasts QL and QR are born in the same anterior/posterior (A/P) position, but polarize and migrate left/right asymmetrically: QL migrates toward the posterior and QR migrates toward the anterior. After their migrations, QL but not QR switches on the Hox gene mab-5. We find that the UNC-40/netrin receptor and a novel transmembrane protein DPY-19 are required to orient these cells correctly. In unc-40 or dpy-19 mutants, the Q cells polarize randomly; in fact, an individual Q cell polarizes in multiple directions over time. In addition, either cell can express MAB-5. Both UNC-40 and DPY-19, as well as the Trio/GTPase exchange factor homolog UNC-73, are required for full polarization and migration. Thus, these proteins appear to participate in a signaling system that orients and polarizes these migrating cells in a left/right asymmetrical fashion during development. The C. elegans netrin UNC-6, which guides many cells and axons along the dorsoventral axis, is not involved in Q cell polarization, suggesting that a different netrin-like ligand serves to polarize these cells along the anteroposterior axis.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  M. Alexander, K. K. M. Chan, A. B. Byrne, G. Selman, T. Lee, J. Ono, E. Wong, R. Puckrin, S. J. Dixon, and P. J. Roy An UNC-40 pathway directs postsynaptic membrane extension in Caenorhabditis elegans Development, March 15, 2009; 136(6): 911 - 922. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Y. Zinovyeva, Y. Yamamoto, H. Sawa, and W. C. Forrester Complex Network of Wnt Signaling Regulates Neuronal Migrations During Caenorhabditis elegans Development Genetics, July 1, 2008; 179(3): 1357 - 1371. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Li, G. Kulkarni, and W. G. Wadsworth RPM-1, a Caenorhabditis elegans Protein That Functions in Presynaptic Differentiation, Negatively Regulates Axon Outgrowth by Controlling SAX-3/robo and UNC-5/UNC5 Activity J. Neurosci., April 2, 2008; 28(14): 3595 - 3603. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. E. Siegrist and C. Q. Doe Microtubule-induced cortical cell polarity Genes & Dev., March 1, 2007; 21(5): 483 - 496. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Shakir, J. S. Gill, and E. A. Lundquist Interactions of UNC-34 Enabled With Rac GTPases and the NIK Kinase MIG-15 in Caenorhabditis elegans Axon Pathfinding and Neuronal Migration Genetics, February 1, 2006; 172(2): 893 - 913. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. A. Rabiner, R. E. Mains, and B. A. Eipper Kalirin: A Dual Rho Guanine Nucleotide Exchange Factor That Is So Much More Than the Sum of Its Many Parts Neuroscientist, April 1, 2005; 11(2): 148 - 160. [Abstract] [PDF]
|
|
|
|
|
|
G. Dalpe, L. Brown, and J. G. Culotti Vulva morphogenesis involves attraction of plexin 1-expressing primordial vulva cells to semaphorin 1a sequentially expressed at the vulva midline Development, March 15, 2005; 132(6): 1387 - 1400. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Causeret, M. Hidalgo-Sanchez, P. Fort, S. Backer, M.-R. Popoff, C. Gauthier-Rouviere, and E. Bloch-Gallego Distinct roles of Rac1/Cdc42 and Rho/Rock for axon outgrowth and nucleokinesis of precerebellar neurons toward netrin 1 Development, June 15, 2004; 131(12): 2841 - 2852. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Ch'ng, L. Williams, Y. S. Lie, M. Sym, J. Whangbo, and C. Kenyon Identification of Genes That Regulate a Left-Right Asymmetric Neuronal Migration in Caenorhabditis elegans Genetics, August 1, 2003; 164(4): 1355 - 1367. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Thieringer, B. Moellers, G. Dodt, W.-H. Kunau, and M. Driscoll Modeling human peroxisome biogenesis disorders in the nematode Caenorhabditis elegans J. Cell Sci., May 1, 2003; 116(9): 1797 - 1804. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Nystrom, Z.-Z. Shen, M. Aili, A. J. Flemming, A. Leroi, and S. Tuck Increased or Decreased Levels of Caenorhabditis elegans lon-3, a Gene Encoding a Collagen, Cause Reciprocal Changes in Body Length Genetics, May 1, 2002; 161(1): 83 - 97. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Bateman and D. Van Vactor The Trio family of guanine-nucleotide-exchange factors: regulators of axon guidance J. Cell Sci., January 6, 2001; 114(11): 1973 - 1980. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. Wei and R. S. Adelstein Pitx2a Expression Alters Actin-Myosin Cytoskeleton and Migration of HeLa Cells through Rho GTPase Signaling Mol. Biol. Cell, February 1, 2002; 13(2): 683 - 697. [Abstract] [Full Text] [PDF]
|
|
