spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bertrand, N.
Right arrow Articles by Pituello, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bertrand, N.
Right arrow Articles by Pituello, F.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Development, Vol 127, Issue 22 4837-4843, Copyright © 2000 by Company of Biologists

JOURNAL ARTICLES

FGF signalling controls the timing of Pax6 activation in the neural tube

N Bertrand, F Medevielle and F Pituello
Centre de Biologie du Developpement, UMR 5547-CNRS-Universite P. Sabatier, 31062 Toulouse cedex 04, France.

We have recently demonstrated that Pax6 activation occurs in phase with somitogenesis in the spinal cord. Here we show that the presomitic mesoderm exerts an inhibitory activity on Pax6 expression. This repressive effect is mediated by the FGF signalling pathway. The presomitic mesoderm displays a decreasing caudorostral gradient of FGF8, and grafting FGF8-soaked beads at the level of the neural tube abolishes Pax6 activation. Conversely, when FGF signalling is disrupted, Pax6 is prematurely activated in the neural plate. We propose that the progression of Pax6 activation in the neural tube is controlled by the caudal regression of the anterior limit of FGF activity. Hence, as part of its posteriorising activity, FGF8 downregulation acts as a switch from early (posterior) to a later (anterior) state of neural epithelial development.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Cold Spring Harb Symp Quant BiolHome page
Y. Elkabetz and L. Studer
Human ESC-derived Neural Rosettes and Neural Stem Cell Progression
Cold Spring Harb Symp Quant Biol, February 9, 2009; (2009) sqb.2008.73.052v1.
[Abstract] [PDF]

Home page
 Phil Trans R Soc BHome page
J. Briscoe and B. G Novitch
Regulatory pathways linking progenitor patterning, cell fates and neurogenesis in the ventral neural tube
Phil Trans R Soc B, January 12, 2008; 363(1489): 57 - 70.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
J. Akai, P. A. Halley, and K. G. Storey
FGF-dependent Notch signaling maintains the spinal cord stem zone
Genes & Dev., December 1, 2005; 19(23): 2877 - 2887.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. Delfino-Machin, J. S. Lunn, D. N. Breitkreuz, J. Akai, and K. G. Storey
Specification and maintenance of the spinal cord stem zone
Development, October 1, 2005; 132(19): 4273 - 4283.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M.-C. Delfini, J. Dubrulle, P. Malapert, J. Chal, and O. Pourquie
Control of the segmentation process by graded MAPK/ERK activation in the chick embryo
PNAS, August 9, 2005; 102(32): 11343 - 11348.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
N. Azuma, K. Tadokoro, A. Asaka, M. Yamada, Y. Yamaguchi, H. Handa, S. Matsushima, T. Watanabe, Y. Kida, T. Ogura, et al.
Transdifferentiation of the retinal pigment epithelia to the neural retina by transfer of the Pax6 transcriptional factor
Hum. Mol. Genet., April 15, 2005; 14(8): 1059 - 1068.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
J. R. Timmer, C. Wang, and L. Niswander
BMP signaling patterns the dorsal and intermediate neural tube via regulation of homeobox and helix-loop-helix transcription factors
Development, March 7, 2003; 129(10): 2459 - 2472.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
R. D. del Corral, D. N. Breitkreuz, and K. G. Storey
Onset of neuronal differentiation is regulated by paraxial mesoderm and requires attenuation of FGF signalling
Development, January 4, 2002; 129(7): 1681 - 1691.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2000