|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 127, Issue 24 5355-5365, Copyright © 2000 by Company of Biologists
JOURNAL ARTICLES |
GA Grammatopoulos, E Bell, L Toole, A Lumsden and AS Tucker
MRC Centre for Developmental Neurobiology, King's College, Guy's Campus, London SE1 1UL, UK.
Overexpression of Hoxa2 in the chick first branchial arch leads to a transformation of first arch cartilages, such as Meckel's and the quadrate, into second arch elements, such as the tongue skeleton. These duplicated elements are fused to the original in a similar manner to that seen in the Hoxa2 knockout, where the reverse transformation of second to first arch morphology is observed. This confirms the role of Hoxa2 as a selector gene specifying second arch fate. When first arch neural crest alone is targeted, first arch elements are lost, but the Hoxa2-expressing crest is unable to develop into second arch elements. This is not due to Hoxa2 preventing differentiation of cartilages. Upregulation of a second arch marker in the first arch, and homeotic transformation of cartilage elements is only produced after global Hoxa2 overexpression in the crest and the surrounding tissue. Thus, although the neural crest appears to contain some patterning information, it needs to read cues from the environment to form a coordinated pattern. Hoxa2 appears to exert its effect during differentiation of the cartilage elements in the branchial arches, rather than during crest migration, implying that pattern is determined quite late in development.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  M. Minoux, G. S. Antonarakis, M. Kmita, D. Duboule, and F. M. Rijli Rostral and caudal pharyngeal arches share a common neural crest ground pattern Development, February 15, 2009; 136(4): 637 - 645. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. F. Eames and R. A. Schneider The genesis of cartilage size and shape during development and evolution Development, December 1, 2008; 135(23): 3947 - 3958. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Laue, S. Daujat, J. G. Crump, N. Plaster, H. H. Roehl, Tubingen 2000 Screen Consortium, C. B. Kimmel, R. Schneider, and M. Hammerschmidt The multidomain protein Brpf1 binds histones and is required for Hox gene expression and segmental identity Development, June 1, 2008; 135(11): 1935 - 1946. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Rinon, S. Lazar, H. Marshall, S. Buchmann-Moller, A. Neufeld, H. Elhanany-Tamir, M. M. Taketo, L. Sommer, R. Krumlauf, and E. Tzahor Cranial neural crest cells regulate head muscle patterning and differentiation during vertebrate embryogenesis Development, September 1, 2007; 134(17): 3065 - 3075. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. E. Creuzet, S. Martinez, and N. M. Le Douarin The cephalic neural crest exerts a critical effect on forebrain and midbrain development PNAS, September 19, 2006; 103(38): 14033 - 14038. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. von Scheven, L. E. Alvares, R. C. Mootoosamy, and S. Dietrich Neural tube derived signals and Fgf8 act antagonistically to specify eye versus mandibular arch muscles Development, July 15, 2006; 133(14): 2731 - 2745. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. G. Crump, M. E. Swartz, J. K. Eberhart, and C. B. Kimmel Moz-dependent Hox expression controls segment-specific fate maps of skeletal precursors in the face Development, July 15, 2006; 133(14): 2661 - 2669. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Santagati, M. Minoux, S.-Y. Ren, and F. M. Rijli Temporal requirement of Hoxa2 in cranial neural crest skeletal morphogenesis Development, November 15, 2005; 132(22): 4927 - 4936. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Kutejova, B. Engist, M. Mallo, B. Kanzler, and N. Bobola Hoxa2 downregulates Six2 in the neural crest-derived mesenchyme Development, February 1, 2005; 132(3): 469 - 478. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. M. Le Douarin, S. Creuzet, G. Couly, and E. Dupin Neural crest cell plasticity and its limits Development, October 1, 2004; 131(19): 4637 - 4650. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Briscoe and D. G. Wilkinson Establishing neuronal circuitry: Hox genes make the connection Genes & Dev., July 15, 2004; 18(14): 1643 - 1648. [Full Text] [PDF]
|
|
|
|
|
|
C. T. Miller, L. Maves, and C. B. Kimmel moz regulates Hox expression and pharyngeal segmental identity in zebrafish Development, May 15, 2004; 131(10): 2443 - 2461. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Jeong, J. Mao, T. Tenzen, A. H. Kottmann, and A. P. McMahon Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia Genes & Dev., April 15, 2004; 18(8): 937 - 951. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Murakami, M. Pasqualetti, Y. Takio, S. Hirano, F. M. Rijli, and S. Kuratani Segmental development of reticulospinal and branchiomotor neurons in lamprey: insights into the evolution of the vertebrate hindbrain Development, March 1, 2004; 131(5): 983 - 995. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Abzhanov, E. Tzahor, A. B. Lassar, and C. J. Tabin Dissimilar regulation of cell differentiation in mesencephalic (cranial) and sacral (trunk) neural crest cells in vitro Development, October 1, 2003; 130(19): 4567 - 4579. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Bobola, M. Carapuco, S. Ohnemus, B. Kanzler, A. Leibbrandt, A. Neubuser, J. Drouin, and M. Mallo Mesenchymal patterning by Hoxa2 requires blocking Fgf-dependent activation of Ptx1 Development, August 1, 2003; 130(15): 3403 - 3414. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Hu, R. S. Marcucio, and J. A. Helms A zone of frontonasal ectoderm regulates patterning and growth in the face Development, May 1, 2003; 130(9): 1749 - 1758. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Creuzet, G. Couly, C. Vincent, and N. M. Le Douarin Negative effect of Hox gene expression on the development of the neural crest-derived facial skeleton Development, March 11, 2003; 129(18): 4301 - 4313. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A. Trainor, D. Sobieszczuk, D. Wilkinson, and R. Krumlauf Signalling between the hindbrain and paraxial tissues dictates neural crest migration pathways Development, March 3, 2003; 129(2): 433 - 442. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. A. Trainor, L. Ariza-McNaughton, and R. Krumlauf Role of the Isthmus and FGFs in Resolving the Paradox of Neural Crest Plasticity and Prepatterning Science, February 15, 2002; 295(5558): 1288 - 1291. [Abstract] [Full Text] [PDF]
|
|
