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Development, Vol 127, Issue 3 483-492, Copyright © 2000 by Company of Biologists
JOURNAL ARTICLES |
L De Moerlooze, B Spencer-Dene, J Revest, M Hajihosseini, I Rosewell and C Dickson
Imperial Cancer Research Fund, Lincoln's Inn Fields, London WC2A 3PX, UK. dickson@icrf.icnet.uk
The fibroblast growth factor receptor 2 gene is differentially spliced to encode two transmembrane tyrosine kinase receptor proteins that have different ligand-binding specificities and exclusive tissue distributions. We have used Cre-mediated excision to generate mice lacking the IIIb form of fibroblast growth factor receptor 2 whilst retaining expression of the IIIc form. Fibroblast growth factor receptor 2(IIIb) null mice are viable until birth, but have severe defects of the limbs, lung and anterior pituitary gland. The development of these structures appears to initiate, but then fails with the tissues undergoing extensive apoptosis. There are also developmental abnormalities of the salivary glands, inner ear, teeth and skin, as well as minor defects in skull formation. Our findings point to a key role for fibroblast growth factor receptor 2(IIIb) in mesenchymal-epithelial signalling during early organogenesis.
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I. Hokuto, A.-K. T. Perl, and J. A. Whitsett Prenatal, but Not Postnatal, Inhibition of Fibroblast Growth Factor Receptor Signaling Causes Emphysema J. Biol. Chem., January 3, 2003; 278(1): 415 - 421. [Abstract] [Full Text] [PDF]
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 K. Kratochwil, J. Galceran, S. Tontsch, W. Roth, and R. Grosschedl FGF4, a direct target of LEF1 and Wnt signaling, can rescue the arrest of tooth organogenesis in Lef1-/- mice Genes & Dev., December 15, 2002; 16(24): 3173 - 3185. [Abstract] [Full Text] [PDF]
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J. Aubin, U. Dery, M. Lemieux, P. Chailler, and L. Jeannotte Stomach regional specification requires Hoxa5-driven mesenchymal-epithelial signaling Development, September 1, 2002; 129(17): 4075 - 4087. [Abstract] [Full Text] [PDF]
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J. A. Whitsett, J. C. Clark, L. Picard, J. W. Tichelaar, S. E. Wert, N. Itoh, A.-K. T. Perl, and M. T. Stahlman Fibroblast Growth Factor 18 Influences Proximal Programming during Lung Morphogenesis J. Biol. Chem., June 14, 2002; 277(25): 22743 - 22749. [Abstract] [Full Text] [PDF]
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 L. E. Olson and M. G. Rosenfeld Perspective: Genetic and Genomic Approaches in Elucidating Mechanisms of Pituitary Development Endocrinology, June 1, 2002; 143(6): 2007 - 2011. [Abstract] [Full Text] [PDF]
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 K. M. Scully and M. G. Rosenfeld Pituitary Development: Regulatory Codes in Mammalian Organogenesis Science, March 22, 2002; 295(5563): 2231 - 2235. [Abstract] [Full Text] [PDF]
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A. A. Mailleux, B. Spencer-Dene, C. Dillon, D. Ndiaye, C. Savona-Baron, N. Itoh, S. Kato, C. Dickson, J. P. Thiery, and S. Bellusci Role of FGF10/FGFR2b signaling during mammary gland development in the mouse embryo Development, January 1, 2002; 129(1): 53 - 60. [Abstract] [Full Text] [PDF]
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A. Bhushan, N. Itoh, S. Kato, J. P. Thiery, P. Czernichow, S. Bellusci, and R. Scharfmann Fgf10 is essential for maintaining the proliferative capacity of epithelial progenitor cells during early pancreatic organogenesis Development, December 15, 2001; 128(24): 5109 - 5117. [Abstract] [Full Text] [PDF]
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C. Le Guiner, A. Plet, D. Galiana, M.-C. Gesnel, F. Del Gatto-Konczak, and R. Breathnach Polypyrimidine Tract-binding Protein Represses Splicing of a Fibroblast Growth Factor Receptor-2 Gene Alternative Exon through Exon Sequences J. Biol. Chem., November 16, 2001; 276(47): 43677 - 43687. [Abstract] [Full Text] [PDF]
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 J.-M. Revest, R. K. Suniara, K. Kerr, J. J. T. Owen, and C. Dickson Development of the Thymus Requires Signaling Through the Fibroblast Growth Factor Receptor R2-IIIb J. Immunol., August 15, 2001; 167(4): 1954 - 1961. [Abstract] [Full Text] [PDF]
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 J. A. Whitsett, S. W. Glasser, J. W. Tichelaar, A.-K. T. Perl, J. C. Clark, and S. E. Wert Transgenic Models for Study of Lung Morphogenesis and Repair : Parker B. Francis Lecture Chest, July 1, 2001; 120(2007): 27S - 30S. [Full Text] [PDF]
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M. Mahlapuu, S. Enerback, and P. Carlsson Haploinsufficiency of the forkhead gene Foxf1, a target for sonic hedgehog signaling, causes lung and foregut malformations Development, June 15, 2001; 128(12): 2397 - 2406. [Abstract] [Full Text] [PDF]
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J. S. Colvin, A. C. White, S. J. Pratt, and D. M. Ornitz Lung hypoplasia and neonatal death in Fgf9-null mice identify this gene as an essential regulator of lung mesenchyme Development, June 1, 2001; 128(11): 2095 - 2106. [Abstract] [Full Text] [PDF]
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 X. Li, Y. Chen, S. Scheele, E. Arman, R. Haffner-Krausz, P. Ekblom, and P. Lonai Fibroblast Growth Factor Signaling and Basement Membrane Assembly Are Connected during Epithelial Morphogenesis of the Embryoid Body J. Cell Biol., May 14, 2001; 153(4): 811 - 822. [Abstract] [Full Text] [PDF]
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J. C. Clark, J. W. Tichelaar, S. E. Wert, N. Itoh, A.-K. T. Perl, M. T. Stahlman, and J. A. Whitsett FGF-10 disrupts lung morphogenesis and causes pulmonary adenomas in vivo Am J Physiol Lung Cell Mol Physiol, April 1, 2001; 280(4): L705 - L715. [Abstract] [Full Text] [PDF]
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K. Yu and D. M. Ornitz Uncoupling fibroblast growth factor receptor 2 ligand binding specificity leads to Apert syndrome-like phenotypes PNAS, March 27, 2001; 98(7): 3641 - 3643. [Full Text] [PDF]
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M. K. Hajihosseini, S. Wilson, L. De Moerlooze, and C. Dickson A splicing switch and gain-of-function mutation in FgfR2-IIIc hemizygotes causes Apert/Pfeiffer-syndrome-like phenotypes PNAS, March 27, 2001; 98(7): 3855 - 3860. [Abstract] [Full Text] [PDF]
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M Treier, S O'Connell, A Gleiberman, J Price, D. Szeto, R Burgess, P. Chuang, A. McMahon, and M. Rosenfeld Hedgehog signaling is required for pituitary gland development Development, January 2, 2001; 128(3): 377 - 386. [Abstract] [PDF]
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 U. Pirvola, B. Spencer-Dene, L. Xing-Qun, P. Kettunen, I. Thesleff, B. Fritzsch, C. Dickson, and J. Ylikoski FGF/FGFR-2(IIIb) Signaling Is Essential for Inner Ear Morphogenesis J. Neurosci., August 15, 2000; 20(16): 6125 - 6134. [Abstract] [Full Text] [PDF]
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R Haraguchi, K Suzuki, R Murakami, M Sakai, M Kamikawa, M Kengaku, K Sekine, H Kawano, S Kato, N Ueno, et al. Molecular analysis of external genitalia formation: the role of fibroblast growth factor (Fgf) genes during genital tubercle formation Development, January 6, 2000; 127(11): 2471 - 2479. [Abstract] [PDF]
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H. Makarenkova, M Ito, V Govindarajan, S. Faber, L Sun, G McMahon, P. Overbeek, and R. Lang FGF10 is an inducer and Pax6 a competence factor for lacrimal gland development Development, January 6, 2000; 127(12): 2563 - 2572. [Abstract] [PDF]
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M Weaver, N. Dunn, and B. Hogan Bmp4 and Fgf10 play opposing roles during lung bud morphogenesis Development, January 6, 2000; 127(12): 2695 - 2704. [Abstract] [PDF]
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