|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 127, Issue 5 933-944, Copyright © 2000 by Company of Biologists
JOURNAL ARTICLES |
JR Barrow, HS Stadler and MR Capecchi
Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.
Early in its development, the vertebrate hindbrain is transiently subdivided into a series of compartments called rhombomeres. Genes have been identified whose expression patterns distinguish these cellular compartments. Two of these genes, Hoxa1 and Hoxa2, have been shown to be required for proper patterning of the early mouse hindbrain and the associated neural crest. To determine the extent to which these two genes function together to pattern the hindbrain, we generated mice simultaneously mutant at both loci. The hindbrain patterning defects were analyzed in embryos individually mutant for Hoxa1 and Hoxa2 in greater detail and extended to embryos mutant for both genes. From these data a model is proposed to describe how Hoxa1, Hoxa2, Hoxb1, Krox20 (Egr2) and kreisler function together to pattern the early mouse hindbrain. Critical to the model is the demonstration that Hoxa1 activity is required to set the anterior limit of Hoxb1 expression at the presumptive r3/4 rhombomere boundary. Failure to express Hoxb1 to this boundary in Hoxa1 mutant embryos initiates a cascade of gene misexpressions that result in misspecification of the hindbrain compartments from r2 through r5. Subsequent to misspecification of the hindbrain compartments, ectopic induction of apoptosis appears to be used to regulate the aberrant size of the misspecified rhombomeres.
This article has been cited by other articles:
|
|
 |
|
  M. A. Wassef, D. Chomette, M. Pouilhe, A. Stedman, E. Havis, C. Desmarquet-Trin Dinh, S. Schneider-Maunoury, P. Gilardi-Hebenstreit, P. Charnay, and J. Ghislain Rostral hindbrain patterning involves the direct activation of a Krox20 transcriptional enhancer by Hox/Pbx and Meis factors Development, October 15, 2008; 135(20): 3369 - 3378. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Pandey, J. K. Perry, K. M. Mohankumar, X.-J. Kong, S.-M. Liu, Z.-S. Wu, M. D. Mitchell, T. Zhu, and P. E. Lobie Autocrine Human Growth Hormone Stimulates Oncogenicity of Endometrial Carcinoma Cells Endocrinology, August 1, 2008; 149(8): 3909 - 3919. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Lampe, O. A. Samad, A. Guiguen, C. Matis, S. Remacle, J. J. Picard, F. M. Rijli, and R. Rezsohazy An ultraconserved Hox-Pbx responsive element resides in the coding sequence of Hoxa2 and is active in rhombomere 4 Nucleic Acids Res., June 1, 2008; 36(10): 3214 - 3225. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. P. Atkinson, C. M. Koch, G. K. Clelland, S. Willcox, J. C. Fowler, R. Stewart, M. Lako, I. Dunham, and L. Armstrong Epigenetic Marking Prepares the Human HOXA Cluster for Activation During Differentiation of Pluripotent Cells Stem Cells, May 1, 2008; 26(5): 1174 - 1185. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Sieber, R. Storm, M. Martinez-de-la-Torre, T. Muller, H. Wende, K. Reuter, E. Vasyutina, and C. Birchmeier Lbx1 Acts as a Selector Gene in the Fate Determination of Somatosensory and Viscerosensory Relay Neurons in the Hindbrain J. Neurosci., May 2, 2007; 27(18): 4902 - 4909. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Chomette, M. Frain, S. Cereghini, P. Charnay, and J. Ghislain Krox20 hindbrain cis-regulatory landscape: interplay between multiple long-range initiation and autoregulatory elements Development, April 1, 2006; 133(7): 1253 - 1262. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Martinez-Ceballos, P. Chambon, and L. J. Gudas Differences in Gene Expression between Wild Type and Hoxa1 Knockout Embryonic Stem Cells after Retinoic Acid Treatment or Leukemia Inhibitory Factor (LIF) Removal J. Biol. Chem., April 22, 2005; 280(16): 16484 - 16498. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Y. H. Li, Z. Lao, and A. L. Joyner New regulatory interactions and cellular responses in the isthmic organizer region revealed by altering Gbx2 expression Development, April 15, 2005; 132(8): 1971 - 1981. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Huang, M. Rastegar, C. Bodner, S.-L. Goh, I. Rambaldi, and M. Featherstone MEIS C Termini Harbor Transcriptional Activation Domains That Respond to Cell Signaling J. Biol. Chem., March 18, 2005; 280(11): 10119 - 10127. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Murakami, M. Pasqualetti, Y. Takio, S. Hirano, F. M. Rijli, and S. Kuratani Segmental development of reticulospinal and branchiomotor neurons in lamprey: insights into the evolution of the vertebrate hindbrain Development, March 1, 2004; 131(5): 983 - 995. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Deflorian, N. Tiso, E. Ferretti, D. Meyer, F. Blasi, M. Bortolussi, and F. Argenton Prep1.1 has essential genetic functions in hindbrain development and cranial neural crest cell differentiation Development, February 1, 2004; 131(3): 613 - 627. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. H. H. Wong, H. D. Wintch, and M. R. Capecchi Hoxa11 Regulates Stromal Cell Death and Proliferation during Neonatal Uterine Development Mol. Endocrinol., January 1, 2004; 18(1): 184 - 193. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. O. Gaufo, K. R. Thomas, and M. R. Capecchi Hox3 genes coordinate mechanisms of genetic suppression and activation in the generation of branchial and somatic motoneurons Development, November 1, 2003; 130(21): 5191 - 5201. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. McClintock, M. A. Kheirbek, and V. E. Prince Knockdown of duplicated zebrafish hoxb1 genes reveals distinct roles in hindbrain patterning and a novel mechanism of duplicate gene retention Development, March 7, 2003; 129(10): 2339 - 2354. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Zhang, T. Zhu, Y. Chen, H. C. Mertani, K.-O. Lee, and P. E. Lobie Human Growth Hormone-regulated HOXA1 Is a Human Mammary Epithelial Oncogene J. Biol. Chem., February 21, 2003; 278(9): 7580 - 7590. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. H. Davidson, D. R. McClay, and L. Hood Regulatory gene networks and the properties of the developmental process PNAS, February 18, 2003; 100(4): 1475 - 1480. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Manzanares, S. Bel-Vialar, L. Ariza-McNaughton, E. Ferretti, H. Marshall, M. M. Maconochie, F. Blasi, and R. Krumlauf Independent regulation of initiation and maintenance phases of Hoxa3 expression in the vertebrate hindbrain involve auto- and cross-regulatory mechanisms Development, September 15, 2001; 128(18): 3595 - 3607. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. McClintock, R. Carlson, D. M. Mann, and V. E. Prince Consequences of Hox gene duplication in the vertebrates: an investigation of the zebrafish Hox paralogue group 1 genes Development, July 1, 2001; 128(13): 2471 - 2484. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Dupe and A. Lumsden Hindbrain patterning involves graded responses to retinoic acid signalling Development, June 15, 2001; 128(12): 2199 - 2208. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Wendling, N. B. Ghyselinck, P. Chambon, and M. Mark Roles of retinoic acid receptors in early embryonic morphogenesis and hindbrain patterning Development, June 1, 2001; 128(11): 2031 - 2038. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Giudicelli, E. Taillebourg, P. Charnay, and P. Gilardi-Hebenstreit Krox-20 patterns the hindbrain through both cell-autonomous and non cell-autonomous mechanisms Genes & Dev., March 1, 2001; 15(5): 567 - 580. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. Saleh, I. Rambaldi, X.-J. Yang, and M. S. Featherstone Cell Signaling Switches HOX-PBX Complexes from Repressors to Activators of Transcription Mediated by Histone Deacetylases and Histone Acetyltransferases Mol. Cell. Biol., November 15, 2000; 20(22): 8623 - 8633. [Abstract] [Full Text]
|
|
|
|
|
|
K. M. Caron and O. Smithies Extreme hydrops fetalis and cardiovascular abnormalities in mice lacking a functional Adrenomedullin gene PNAS, January 16, 2001; 98(2): 615 - 619. [Abstract] [Full Text] [PDF]
|
|
