|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 127, Issue 6 1209-1220, Copyright © 2000 by Company of Biologists
JOURNAL ARTICLES |
VH Nguyen, J Trout, SA Connors, P Andermann, E Weinberg and MC Mullins
University of Pennsylvania School of Medicine, Department of Cell and Developmental Biology, 421 Curie Blvd, Philadelphia, PA 19104-6058, USA.
We have studied the role of Bmp signaling in patterning neural tissue through the use of mutants in the zebrafish that disrupt three different components of a Bmp signaling pathway: swirl/bmp2b, snailhouse/bmp7 and somitabun/smad5. We demonstrate that Bmp signaling is essential for the establishment of the prospective neural crest and dorsal sensory Rohon-Beard neurons of the spinal cord. Moreover, Bmp signaling is necessary to limit the number of intermediate-positioned lim1+ interneurons of the spinal cord, as observed by the dramatic expansion of these prospective interneurons in many mutant embryos. Our analysis also suggests a positive role for Bmp signaling in the specification of these interneurons, which is independent of Bmp2b/Swirl activity. We found that a presumptive ventral signal, Hh signaling, acts to restrict the amount of dorsal sensory neurons and trunk neural crest. This restriction appears to occur very early in neural tissue development, likely prior to notochord or floor plate formation. A similar early role for Bmp signaling is suggested in the specification of dorsal neural cell types, since the bmp2b/swirl and bmp7/snailhouse genes are only coexpressed during gastrulation and within the tail bud, and are not found in the dorsal neural tube or overlying epidermal ectoderm. Thus, a gastrula Bmp2b/Swirl and Bmp7/Snailhouse-dependent activity gradient may not only act in the specification of the embryonic dorsoventral axis, but may also function in establishing dorsal and intermediate neuronal cell types of the spinal cord.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  P. Herr, G. Korniychuk, Y. Yamamoto, K. Grubisic, and M. Oelgeschlager Regulation of TGF-{beta} signalling by N-acetylgalactosaminyltransferase-like 1 Development, May 15, 2008; 135(10): 1813 - 1822. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Briscoe and B. G Novitch Regulatory pathways linking progenitor patterning, cell fates and neurogenesis in the ventral neural tube Phil Trans R Soc B, January 12, 2008; 363(1489): 57 - 70. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Gerhart, C. Neely, J. Elder, J. Pfautz, J. Perlman, L. Narciso, K. K. Linask, K. Knudsen, and M. George-Weinstein Cells that express MyoD mRNA in the epiblast are stably committed to the skeletal muscle lineage J. Cell Biol., August 9, 2007; 178(4): 649 - 660. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. E Lewis How do genes regulate simple behaviours? Understanding how different neurons in the vertebrate spinal cord are genetically specified Phil Trans R Soc B, January 29, 2006; 361(1465): 45 - 66. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Reversade, H. Kuroda, H. Lee, A. Mays, and E. M. De Robertis Depletion of Bmp2, Bmp4, Bmp7 and Spemann organizer signals induces massive brain formation in Xenopus embryos Development, August 1, 2005; 132(15): 3381 - 3392. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Gestri, M. Carl, I. Appolloni, S. W. Wilson, G. Barsacchi, and M. Andreazzoli Six3 functions in anterior neural plate specification by promoting cell proliferation and inhibiting Bmp4 expression Development, May 15, 2005; 132(10): 2401 - 2413. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. D. Stern Neural induction: old problem, new findings, yet more questions Development, May 1, 2005; 132(9): 2007 - 2021. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. M. Zeltser Shh-dependent formation of the ZLI is opposed by signals from the dorsal diencephalon Development, May 1, 2005; 132(9): 2023 - 2033. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Filippi, N. Tiso, G. Deflorian, E. Zecchin, M. Bortolussi, and F. Argenton The basic helix-loop-helix olig3 establishes the neural plate boundary of the trunk and is necessary for development of the dorsal spinal cord PNAS, March 22, 2005; 102(12): 4377 - 4382. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-K. Bae, T. Shimizu, and M. Hibi Patterning of proneuronal and inter-proneuronal domains by hairy- and enhancer of split-related genes in zebrafish neuroectoderm Development, March 15, 2005; 132(6): 1375 - 1385. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Wine-Lee, K. J. Ahn, R. D. Richardson, Y. Mishina, K. M. Lyons, and E. B. Crenshaw III Signaling through BMP type 1 receptors is required for development of interneuron cell types in the dorsal spinal cord Development, November 1, 2004; 131(21): 5393 - 5403. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kudoh, M. L. Concha, C. Houart, I. B. Dawid, and S. W. Wilson Combinatorial Fgf and Bmp signalling patterns the gastrula ectoderm into prospective neural and epidermal domains Development, August 1, 2004; 131(15): 3581 - 3592. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Lewis, J. Bonner, M. Modrell, J. W. Ragland, R. T. Moon, R. I. Dorsky, and D. W. Raible Reiterated Wnt signaling during zebrafish neural crest development Development, March 15, 2004; 131(6): 1299 - 1308. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Liu, A. W. Helms, and J. E. Johnson Distinct activities of Msx1 and Msx3 in dorsal neural tube development Development, March 1, 2004; 131(5): 1017 - 1028. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Marlow,, E. M. Gonzalez,,, C. Yin, C. Rojo, and L. Solnica-Krezel, No tail co-operates with non-canonical Wnt signaling to regulate posterior body morphogenesis in zebrafish Development, January 1, 2004; 131(1): 203 - 216. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Tribulo, M. J. Aybar, V. H. Nguyen, M. C. Mullins, and R. Mayor Regulation of Msx genes by a Bmp gradient is essential for neural crest specification Development, December 29, 2003; 130(26): 6441 - 6452. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. M. Pera, A. Ikeda, E. Eivers, and E. M. De Robertis Integration of IGF, FGF, and anti-BMP signals via Smad1 phosphorylation in neural induction Genes & Dev., December 15, 2003; 17(24): 3023 - 3028. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-K. Bae, T. Shimizu, T. Yabe, C.-H. Kim, T. Hirata, H. Nojima, O. Muraoka, T. Hirano, and M. Hibi A homeobox gene, pnx, is involved in the formation of posterior neurons in zebrafish Development, May 1, 2003; 130(9): 1853 - 1865. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Persson, D. Stamataki, P. te Welscher, E. Andersson, J. Bose, U. Ruther, J. Ericson, and J. Briscoe Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity Genes & Dev., November 15, 2002; 16(22): 2865 - 2878. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. I. Garcia-Castro, C. Marcelle, and M. Bronner-Fraser Ectodermal Wnt Function as a Neural Crest Inducer Science, August 2, 2002; 297(5582): 848 - 851. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. E. Rusten, R. Cantera, F. C. Kafatos, and R. Barrio The role of TGF{beta} signaling in the formation of the dorsal nervous system is conserved between Drosophila and chordates Development, August 1, 2002; 129(15): 3575 - 3584. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Panchision, J. M. Pickel, L. Studer, S.-H. Lee, P. A. Turner, T. G. Hazel, and R. D.G. McKay Sequential actions of BMP receptors control neural precursor cell production and fate Genes & Dev., August 15, 2001; 15(16): 2094 - 2110. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-P. Heisenberg, C. Houart, M. Take-uchi, G.-J. Rauch, N. Young, P. Coutinho, I. Masai, L. Caneparo, M. L. Concha, R. Geisler, et al. A mutation in the Gsk3-binding domain of zebrafish Masterblind/Axin1 leads to a fate transformation of telencephalon and eyes to diencephalon Genes & Dev., June 1, 2001; 15(11): 1427 - 1434. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M Patruno, M. Thorndyke, M. Candia Carnevali, F Bonasoro, and P. Beesley Growth factors, heat-shock proteins and regeneration in echinoderms J. Exp. Biol., January 3, 2001; 204(5): 843 - 848. [Abstract] [PDF]
|
|
|
|
 |
|
 P. Blader and U. Strahle Zebrafish developmental genetics and central nervous system development Hum. Mol. Genet., April 1, 2000; 9(6): 945 - 951. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Liem, T. Jessell, and J Briscoe Regulation of the neural patterning activity of sonic hedgehog by secreted BMP inhibitors expressed by notochord and somites Development, January 11, 2000; 127(22): 4855 - 4866. [Abstract] [PDF]
|
|
