Development, Vol 127, Issue 8 1607-1616, Copyright © 2000 by Company of Biologists

JOURNAL ARTICLES

Fate of the mammalian cardiac neural crest

X Jiang, DH Rowitch, P Soriano, AP McMahon and HM Sucov
Departments of Biological Sciences and Cell & Neurobiology, Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, IGM 240, Los Angeles, CA 90033, USA.

A subpopulation of neural crest termed the cardiac neural crest is required in avian embryos to initiate reorganization of the outflow tract of the developing cardiovascular system. In mammalian embryos, it has not been previously experimentally possible to study the long-term fate of this population, although there is strong inference that a similar population exists and is perturbed in a number of genetic and teratogenic contexts. We have employed a two-component genetic system based on Cre/lox recombination to label indelibly the entire mouse neural crest population at the time of its formation, and to detect it at any time thereafter. Labeled cells are detected throughout gestation and in postnatal stages in major tissues that are known or predicted to be derived from neural crest. Labeling is highly specific and highly efficient. In the region of the heart, neural-crest-derived cells surround the pharyngeal arch arteries from the time of their formation and undergo an altered distribution coincident with the reorganization of these vessels. Labeled cells populate the aorticopulmonary septum and conotruncal cushions prior to and during overt septation of the outflow tract, and surround the thymus and thyroid as these organs form. Neural-crest-derived mesenchymal cells are abundantly distributed in midgestation (E9.5-12.5), and adult derivatives of the third, fourth and sixth pharyngeal arch arteries retain a substantial contribution of labeled cells. However, the population of neural-crest-derived cells that infiltrates the conotruncus and which surrounds the noncardiac pharyngeal organs is either overgrown or selectively eliminated as development proceeds, resulting for these tissues in a modest to marginal contribution in late fetal and postnatal life.
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				M. Ishii, A. E. Merrill, Y.-S. Chan, I. Gitelman, D. P. C. Rice, H. M. Sucov, and R. E. Maxson Jr Msx2 and Twist cooperatively control the development of the neural crest-derived skeletogenic mesenchyme of the murine skull vault Development, December 15, 2003; 130(24): 6131 - 6142. [Abstract] [Full Text] [PDF]

				S. G. Katz, A. Williams, J. Yang, Y. Fujiwara, A. P. Tsang, J. A. Epstein, and S. H. Orkin Endothelial lineage-mediated loss of the GATA cofactor Friend of GATA 1 impairs cardiac development PNAS, November 25, 2003; 100(24): 14030 - 14035. [Abstract] [Full Text] [PDF]

				Y. Mori-Akiyama, H. Akiyama, D. H. Rowitch, and B. de Crombrugghe Sox9 is required for determination of the chondrogenic cell lineage in the cranial neural crest PNAS, August 5, 2003; 100(16): 9360 - 9365. [Abstract] [Full Text] [PDF]

				A. Flesken-Nikitin, K.-C. Choi, J. P. Eng, E. N. Shmidt, and A. Yu. Nikitin Induction of Carcinogenesis by Concurrent Inactivation of p53 and Rb1 in the Mouse Ovarian Surface Epithelium Cancer Res., July 1, 2003; 63(13): 3459 - 3463. [Abstract] [Full Text] [PDF]

				K. Niederreither, J. Vermot, I. L. Roux, B. Schuhbaur, P. Chambon, and P. Dolle The regional pattern of retinoic acid synthesis by RALDH2 is essential for the development of posterior pharyngeal arches and the enteric nervous system Development, June 1, 2003; 130(11): 2525 - 2534. [Abstract] [Full Text] [PDF]

				S. J. Kwang, S. M. Brugger, A. Lazik, A. E. Merrill, L.-Y. Wu, Y.-H. Liu, M. Ishii, F. O. Sangiorgi, M. Rauchman, H. M. Sucov, et al. Msx2 is an immediate downstream effector of Pax3 in the development of the murine cardiac neural crest Development, March 3, 2003; 129(2): 527 - 538. [Abstract] [Full Text] [PDF]

				Y. Chai, Y. Ito, and J. Han TGF-{beta} SIGNALING AND ITS FUNCTIONAL SIGNIFICANCE IN REGULATING THE FATE OF CRANIAL NEURAL CREST CELLS Critical Reviews in Oral Biology & Medicine, March 1, 2003; 14(2): 78 - 88. [Abstract] [Full Text] [PDF]

				M. D. Tallquist and P. Soriano Cell autonomous requirement for PDGFR{alpha} in populations of cranial and cardiac neural crest cells Development, February 1, 2003; 130(3): 507 - 518. [Abstract] [Full Text] [PDF]

				K. Schafer, P. Neuhaus, J. Kruse, and T. Braun The Homeobox Gene Lbx1 Specifies a Subpopulation of Cardiac Neural Crest Necessary for Normal Heart Development Circ. Res., January 10, 2003; 92(1): 73 - 80. [Abstract] [Full Text] [PDF]

				E. C. Delot, M. E. Bahamonde, M. Zhao, and K. M. Lyons BMP signaling is required for septation of the outflow tract of the mammalian heart Development, January 1, 2003; 130(1): 209 - 220. [Abstract] [Full Text] [PDF]

				L. Hari, V. Brault, M. Kleber, H.-Y. Lee, F. Ille, R. Leimeroth, C. Paratore, U. Suter, R. Kemler, and L. Sommer Lineage-specific requirements of {beta}-catenin in neural crest development J. Cell Biol., December 9, 2002; 159(5): 867 - 880. [Abstract] [Full Text] [PDF]

				D. G.M Molin, M. C DeRuiter, L. J Wisse, M. Azhar, T. Doetschman, R. E Poelmann, and A. C Gittenberger-de Groot Altered apoptosis pattern during pharyngeal arch artery remodelling is associated with aortic arch malformations in Tgf{beta}2 knock-out mice Cardiovasc Res, November 1, 2002; 56(2): 312 - 322. [Abstract] [Full Text] [PDF]

				I. Lagutina, S. J. Conway, J. Sublett, and G. C. Grosveld Pax3-FKHR Knock-In Mice Show Developmental Aberrations but Do Not Develop Tumors Mol. Cell. Biol., October 15, 2002; 22(20): 7204 - 7216. [Abstract] [Full Text] [PDF]

				M. L. Kirby Embryogenesis of Transposition of the Great Arteries: A Lesson From the Heart Circ. Res., July 26, 2002; 91(2): 87 - 89. [Full Text] [PDF]