spacer gif spacer gif spacer gif spacer gif ARCHIVE ANNOUNCEMENT! spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jiang, X.
Right arrow Articles by Sucov, H. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jiang, X.
Right arrow Articles by Sucov, H. M.

Development, Vol 127, Issue 8 1607-1616, Copyright © 2000 by Company of Biologists

JOURNAL ARTICLES

Fate of the mammalian cardiac neural crest

X Jiang, DH Rowitch, P Soriano, AP McMahon and HM Sucov
Departments of Biological Sciences and Cell & Neurobiology, Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, IGM 240, Los Angeles, CA 90033, USA.

A subpopulation of neural crest termed the cardiac neural crest is required in avian embryos to initiate reorganization of the outflow tract of the developing cardiovascular system. In mammalian embryos, it has not been previously experimentally possible to study the long-term fate of this population, although there is strong inference that a similar population exists and is perturbed in a number of genetic and teratogenic contexts. We have employed a two-component genetic system based on Cre/lox recombination to label indelibly the entire mouse neural crest population at the time of its formation, and to detect it at any time thereafter. Labeled cells are detected throughout gestation and in postnatal stages in major tissues that are known or predicted to be derived from neural crest. Labeling is highly specific and highly efficient. In the region of the heart, neural-crest-derived cells surround the pharyngeal arch arteries from the time of their formation and undergo an altered distribution coincident with the reorganization of these vessels. Labeled cells populate the aorticopulmonary septum and conotruncal cushions prior to and during overt septation of the outflow tract, and surround the thymus and thyroid as these organs form. Neural-crest-derived mesenchymal cells are abundantly distributed in midgestation (E9.5-12.5), and adult derivatives of the third, fourth and sixth pharyngeal arch arteries retain a substantial contribution of labeled cells. However, the population of neural-crest-derived cells that infiltrates the conotruncus and which surrounds the noncardiac pharyngeal organs is either overgrown or selectively eliminated as development proceeds, resulting for these tissues in a modest to marginal contribution in late fetal and postnatal life.


This article has been cited by other articles:


Home page
 DevelopmentHome page
P. Leucht, J.-B. Kim, R. Amasha, A. W. James, S. Girod, and J. A. Helms
Embryonic origin and Hox status determine progenitor cell fate during adult bone regeneration
Development, September 1, 2008; 135(17): 2845 - 2854.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
S. T. MacDonald, S. D. Bamforth, C.-M. Chen, C. R. Farthing, A. Franklyn, C. Broadbent, J. E. Schneider, Y. Saga, M. Lewandoski, and S. Bhattacharya
Epiblastic Cited2 deficiency results in cardiac phenotypic heterogeneity and provides a mechanism for haploinsufficiency
Cardiovasc Res, August 1, 2008; 79(3): 448 - 457.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. N. Passman, X. R. Dong, S.-P. Wu, C. T. Maguire, K. A. Hogan, V. L. Bautch, and M. W. Majesky
A sonic hedgehog signaling domain in the arterial adventitia supports resident Sca1+ smooth muscle progenitor cells
PNAS, July 8, 2008; 105(27): 9349 - 9354.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
K. Niessen and A. Karsan
Notch Signaling in Cardiac Development
Circ. Res., May 23, 2008; 102(10): 1169 - 1181.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
P. Wasteson, B. R. Johansson, T. Jukkola, S. Breuer, L. M. Akyurek, J. Partanen, and P. Lindahl
Developmental origin of smooth muscle cells in the descending aorta in mice
Development, May 15, 2008; 135(10): 1823 - 1832.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
Q. Schwarz, J. M. Vieira, B. Howard, B. J. Eickholt, and C. Ruhrberg
Neuropilin 1 and 2 control cranial gangliogenesis and axon guidance through neural crest cells
Development, May 1, 2008; 135(9): 1605 - 1613.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. M. Muller, C. C. Stolt, G. Terszowski, C. Blum, T. Amagai, N. Kessaris, P. Iannarelli, W. D. Richardson, M. Wegner, and H.-R. Rodewald
Neural Crest Origin of Perivascular Mesenchyme in the Adult Thymus
J. Immunol., April 15, 2008; 180(8): 5344 - 5351.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
X. Sun, R. Zhang, X. Lin, and X. Xu
Wnt3a Regulates the Development of Cardiac Neural Crest Cells by Modulating Expression of Cysteine-Rich Intestinal Protein 2 in Rhombomere 6
Circ. Res., April 11, 2008; 102(7): 831 - 839.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. Foster, J. Sheridan, H. Veiga-Fernandes, K. Roderick, V. Pachnis, R. Adams, C. Blackburn, D. Kioussis, and M. Coles
Contribution of Neural Crest-Derived Cells in the Embryonic and Adult Thymus
J. Immunol., March 1, 2008; 180(5): 3183 - 3189.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
S. Navankasattusas, K. J. Whitehead, A. Suli, L. K. Sorensen, A. H. Lim, J. Zhao, K. W. Park, J. D. Wythe, K. R. Thomas, C.-B. Chien, et al.
The netrin receptor UNC5B promotes angiogenesis in specific vascular beds
Development, February 15, 2008; 135(4): 659 - 667.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
Y. Liu, F.-C. Yang, T. Okuda, X. Dong, M. J. Zylka, C.-L. Chen, D. J. Anderson, R. Kuner, and Q. Ma
Mechanisms of Compartmentalized Expression of Mrg Class G-Protein-Coupled Sensory Receptors
J. Neurosci., January 2, 2008; 28(1): 125 - 132.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
D. P.J. Hunt, P. N. Morris, J. Sterling, J. A. Anderson, A. Joannides, C. Jahoda, A. Compston, and S. Chandran
A Highly Enriched Niche of Precursor Cells with Neuronal and Glial Potential Within the Hair Follicle Dermal Papilla of Adult Skin
Stem Cells, January 1, 2008; 26(1): 163 - 172.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
E. J. Robertson, I. Charatsi, C. J. Joyner, C. H. Koonce, M. Morgan, A. Islam, C. Paterson, E. Lejsek, S. J. Arnold, A. Kallies, et al.
Blimp1 regulates development of the posterior forelimb, caudal pharyngeal arches, heart and sensory vibrissae in mice
Development, December 15, 2007; 134(24): 4335 - 4345.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
V. Todorovic, D. Frendewey, D. E. Gutstein, Y. Chen, L. Freyer, E. Finnegan, F. Liu, A. Murphy, D. Valenzuela, G. Yancopoulos, et al.
Long form of latent TGF-{beta} binding protein 1 (Ltbp1L) is essential for cardiac outflow tract septation and remodeling
Development, October 15, 2007; 134(20): 3723 - 3732.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
Y. Kameda, T. Nishimaki, O. Chisaka, S. Iseki, and H. M. Sucov
Expression of the Epithelial Marker E-Cadherin by Thyroid C Cells and Their Precursors During Murine Development
J. Histochem. Cytochem., October 1, 2007; 55(10): 1075 - 1088.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
M. Itoi, N. Tsukamoto, H. Yoshida, and T. Amagai
Mesenchymal cells are required for functional development of thymic epithelial cells
Int. Immunol., August 1, 2007; 19(8): 953 - 964.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. K. Taylor, K. Yeager, and S. J. Morrison
Physiological Notch signaling promotes gliogenesis in the developing peripheral and central nervous systems
Development, July 1, 2007; 134(13): 2435 - 2447.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
Z. Zhou, A. Flesken-Nikitin, and A. Yu. Nikitin
Prostate Cancer Associated with p53 and Rb Deficiency Arises from the Stem/Progenitor Cell-Enriched Proximal Region of Prostatic Ducts
Cancer Res., June 15, 2007; 67(12): 5683 - 5690.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
N. Billon, P. Iannarelli, M. C. Monteiro, C. Glavieux-Pardanaud, W. D. Richardson, N. Kessaris, C. Dani, and E. Dupin
The generation of adipocytes by the neural crest
Development, June 15, 2007; 134(12): 2283 - 2292.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
M. W. Majesky
Developmental Basis of Vascular Smooth Muscle Diversity
Arterioscler. Thromb. Vasc. Biol., June 1, 2007; 27(6): 1248 - 1258.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
F. Zwerts, F. Lupu, A. De Vriese, S. Pollefeyt, L. Moons, R. A. Altura, Y. Jiang, P. H. Maxwell, P. Hill, H. Oh, et al.
Lack of endothelial cell survivin causes embryonic defects in angiogenesis, cardiogenesis, and neural tube closure
Blood, June 1, 2007; 109(11): 4742 - 4752.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
L. Lin, L. Cui, W. Zhou, D. Dufort, X. Zhang, C.-L. Cai, L. Bu, L. Yang, J. Martin, R. Kemler, et al.
beta-Catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis
PNAS, May 29, 2007; 104(22): 9313 - 9318.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. H. D. Gray, D. Tull, T. Ueno, N. Seach, B. J. Classon, A. Chidgey, M. J. McConville, and R. L. Boyd
A Unique Thymic Fibroblast Population Revealed by the Monoclonal Antibody MTS-15
J. Immunol., April 15, 2007; 178(8): 4956 - 4965.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
X. Liang, Y. Sun, J. Schneider, J.-H. Ding, H. Cheng, M. Ye, S. Bhattacharya, A. Rearden, S. Evans, and J. Chen
Pinch1 Is Required for Normal Development of Cranial and Cardiac Neural Crest-Derived Structures
Circ. Res., March 2, 2007; 100(4): 527 - 535.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
W. E. Jenkinson, S. W. Rossi, S. M. Parnell, E. J. Jenkinson, and G. Anderson
PDGFR{alpha}-expressing mesenchyme regulates thymus growth and the availability of intrathymic niches
Blood, February 1, 2007; 109(3): 954 - 960.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Biol.Home page
C. E. Wong, C. Paratore, M. T. Dours-Zimmermann, A. Rochat, T. Pietri, U. Suter, D. R. Zimmermann, S. Dufour, J. P. Thiery, D. Meijer, et al.
Neural crest-derived cells with stem cell features can be traced back to multiple lineages in the adult skin
J. Cell Biol., December 18, 2006; 175(6): 1005 - 1015.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
C. Roberts, S. Ivins, A. C. Cook, A. Baldini, and P. J. Scambler
Cyp26 genes a1, b1 and c1 are down-regulated in Tbx1 null mice and inhibition of Cyp26 enzyme function produces a phenocopy of DiGeorge Syndrome in the chick
Hum. Mol. Genet., December 1, 2006; 15(23): 3394 - 3410.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
K. Mesbah, A. Camus, C. Babinet, and J. Barra
Mutation in the Trap{alpha}/Ssr1 Gene, Encoding Translocon-Associated Protein {alpha}, Results in Outflow Tract Morphogenetic Defects.
Mol. Cell. Biol., October 1, 2006; 26(20): 7760 - 7771.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
D. G.M. Molin and M. J. Post
Do intrinsic arterial wall features determine atherosclerosis susceptibility?
Cardiovasc Res, October 1, 2006; 72(1): 3 - 4.
[Full Text] [PDF]

Home page
 Circ. Res.Home page
T. Nakamura, M. C. Colbert, and J. Robbins
Neural Crest Cells Retain Multipotential Characteristics in the Developing Valves and Label the Cardiac Conduction System
Circ. Res., June 23, 2006; 98(12): 1547 - 1554.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
S. Liu, F. Liu, A. E. Schneider, T. St. Amand, J. A. Epstein, and D. E. Gutstein
Distinct cardiac malformations caused by absence of connexin 43 in the neural crest and in the non-crest neural tube
Development, May 15, 2006; 133(10): 2063 - 2073.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
M. Denham, T. Huynh, M. Dottori, G. Allen, A. Trounson, and R. Mollard
Neural Stem Cells Express Non-Neural Markers During Embryoid Body Coculture
Stem Cells, April 1, 2006; 24(4): 918 - 927.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
C. Pouget, R. Gautier, M.-A. Teillet, and T. Jaffredo
Somite-derived cells replace ventral aortic hemangioblasts and provide aortic smooth muscle cells of the trunk
Development, March 15, 2006; 133(6): 1013 - 1022.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
F. Bajolle, S. Zaffran, R. G. Kelly, J. Hadchouel, D. Bonnet, N. A. Brown, and M. E. Buckingham
Rotation of the Myocardial Wall of the Outflow Tract Is Implicated in the Normal Positioning of the Great Arteries
Circ. Res., February 17, 2006; 98(3): 421 - 428.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
S. A. Mohamed, T. Hanke, C. Schlueter, J. Bullerdiek, and H.-H. Sievers
Ubiquitin fusion degradation 1-like gene dysregulation in bicuspid aortic valve
J. Thorac. Cardiovasc. Surg., December 1, 2005; 130(6): 1531 - 1536.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. Ishii, J. Han, H.-Y. Yen, H. M. Sucov, Y. Chai, and R. E. Maxson Jr
Combined deficiencies of Msx1 and Msx2 cause impaired patterning and survival of the cranial neural crest
Development, November 15, 2005; 132(22): 4937 - 4950.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
P. J. Gage, W. Rhoades, S. K. Prucka, and T. Hjalt
Fate Maps of Neural Crest and Mesoderm in the Mammalian Eye
Invest. Ophthalmol. Vis. Sci., November 1, 2005; 46(11): 4200 - 4208.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
N. Matt, V. Dupe, J.-M. Garnier, C. Dennefeld, P. Chambon, M. Mark, and N. B. Ghyselinck
Retinoic acid-dependent eye morphogenesis is orchestrated by neural crest cells
Development, November 1, 2005; 132(21): 4789 - 4800.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. Li, X. Zhu, M. Chen, L. Cheng, D. Zhou, M. M. Lu, K. Du, J. A. Epstein, and M. S. Parmacek
Myocardin-related transcription factor B is required in cardiac neural crest for smooth muscle differentiation and cardiovascular development
PNAS, June 21, 2005; 102(25): 8916 - 8921.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
H.-M. I. Yu, B. Liu, S.-Y. Chiu, F. Costantini, and W. Hsu
Development of a unique system for spatiotemporal and lineage-specific gene expression in mice
PNAS, June 14, 2005; 102(24): 8615 - 8620.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
L. Lo, E. L. Dormand, and D. J. Anderson
Late-emigrating neural crest cells in the roof plate are restricted to a sensory fate by GDF7
PNAS, May 17, 2005; 102(20): 7192 - 7197.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
H. Yamazaki, E. Sakata, T. Yamane, A. Yanagisawa, K. Abe, K.-I. Yamamura, S.-I. Hayashi, and T. Kunisada
Presence and distribution of neural crest-derived cells in the murine developing thymus and their potential for differentiation
Int. Immunol., May 1, 2005; 17(5): 549 - 558.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
H.-M. I. Yu, B. Jerchow, T.-J. Sheu, B. Liu, F. Costantini, J. E. Puzas, W. Birchmeier, and W. Hsu
The role of Axin2 in calvarial morphogenesis and craniosynostosis
Development, April 15, 2005; 132(8): 1995 - 2005.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
M. Tadano, H. Edamatsu, S. Minamisawa, U. Yokoyama, Y. Ishikawa, N. Suzuki, H. Saito, D. Wu, M. Masago-Toda, Y. Yamawaki-Kataoka, et al.
Congenital Semilunar Valvulogenesis Defect in Mice Deficient in Phospholipase C{varepsilon}
Mol. Cell. Biol., March 15, 2005; 25(6): 2191 - 2199.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
H. Wurdak, L. M. Ittner, K. S. Lang, P. Leveen, U. Suter, J. A. Fischer, S. Karlsson, W. Born, and L. Sommer
Inactivation of TGF{beta} signaling in neural crest stem cells leads to multiple defects reminiscent of DiGeorge syndrome
Genes & Dev., March 1, 2005; 19(5): 530 - 535.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Zamisch, B. Moore-Scott, D.-m. Su, P. J. Lucas, N. Manley, and E. R. Richie
Ontogeny and Regulation of IL-7-Expressing Thymic Epithelial Cells
J. Immunol., January 1, 2005; 174(1): 60 - 67.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
E. J. Huang, H. Li, A. A. Tang, A. K. Wiggins, R. L. Neve, W. Zhong, L. Y. Jan, and Y. N. Jan
Targeted deletion of numb and numblike in sensory neurons reveals their essential functions in axon arborization
Genes & Dev., January 1, 2005; 19(1): 138 - 151.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
D. G.M. Molin, R. E. Poelmann, M. C. DeRuiter, M. Azhar, T. Doetschman, and A. C. Gittenberger-de Groot
Transforming Growth Factor {beta}-SMAD2 Signaling Regulates Aortic Arch Innervation and Development
Circ. Res., November 26, 2004; 95(11): 1109 - 1117.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
N. M. Joseph, Y.-s. Mukouyama, J. T. Mosher, M. Jaegle, S. A. Crone, E.-L. Dormand, K.-F. Lee, D. Meijer, D. J. Anderson, and S. J. Morrison
Neural crest stem cells undergo multilineage differentiation in developing peripheral nerves to generate endoneurial fibroblasts in addition to Schwann cells
Development, November 15, 2004; 131(22): 5599 - 5612.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
F. J. de Lange, A. F.M. Moorman, R. H. Anderson, J. Manner, A. T. Soufan, C. d. G.-d. Vries, M. D. Schneider, S. Webb, M. J.B. van den Hoff, and V. M. Christoffels
Lineage and Morphogenetic Analysis of the Cardiac Valves
Circ. Res., September 17, 2004; 95(6): 645 - 654.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
W. Y. Chan, C. S. Cheung, K. M. Yung, and A. J. Copp
Cardiac neural crest of the mouse embryo: axial level of origin, migratory pathway and cell autonomy of the splotch (Sp2H) mutant effect
Development, July 15, 2004; 131(14): 3367 - 3379.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
V. Kaartinen, M. Dudas, A. Nagy, S. Sridurongrit, M. M. Lu, and J. A. Epstein
Cardiac outflow tract defects in mice lacking ALK2 in neural crest cells
Development, July 15, 2004; 131(14): 3481 - 3490.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
H. Xu, M. Morishima, J. N. Wylie, R. J. Schwartz, B. G. Bruneau, E. A. Lindsay, and A. Baldini
Tbx1 has a dual role in the morphogenesis of the cardiac outflow tract
Development, July 1, 2004; 131(13): 3217 - 3227.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Biol.Home page
K. M. Mann, J. L. Ray, E. S. Moon, K. M. Sass, and M. R. Benson
Calcineurin initiates smooth muscle differentiation in neural crest stem cells
J. Cell Biol., May 24, 2004; 165(4): 483 - 491.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Seeber, A. Humeny, M. Herkert, T. Rau, T. Eschenhagen, and C.-M. Becker
Formation of Molecular Complexes by N-Methyl-D-aspartate Receptor Subunit NR2B and Ryanodine Receptor 2 in Neonatal Rat Myocard
J. Biol. Chem., May 14, 2004; 279(20): 21062 - 21068.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
Y. Kameda, Y. Arai, T. Nishimaki, and O. Chisaka
The Role of Hoxa3 Gene in Parathyroid Gland Organogenesis of the Mouse
J. Histochem. Cytochem., May 1, 2004; 52(5): 641 - 652.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
R. W. Stottmann, M. Choi, Y. Mishina, E. N. Meyers, and J. Klingensmith
BMP receptor IA is required in mammalian neural crest cells for development of the cardiac outflow tract and ventricular myocardium
Development, May 1, 2004; 131(9): 2205 - 2218.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
H. Akiyama, M.-C. Chaboissier, R. R. Behringer, D. H. Rowitch, A. Schedl, J. A. Epstein, and B. de Crombrugghe
Essential role of Sox9 in the pathway that controls formation of cardiac valves and septa
PNAS, April 27, 2004; 101(17): 6502 - 6507.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
J. Jeong, J. Mao, T. Tenzen, A. H. Kottmann, and A. P. McMahon
Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia
Genes & Dev., April 15, 2004; 18(8): 937 - 951.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
W. Liu, J. Selever, D. Wang, M.-F. Lu, K. A. Moses, R. J. Schwartz, and J. F. Martin
Bmp4 signaling is required for outflow-tract septation and branchial-arch artery remodeling
PNAS, March 30, 2004; 101(13): 4489 - 4494.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
M. H. Yacoub and L. H. Cohn
Novel Approaches to Cardiac Valve Repair: From Structure to Function: Part I
Circulation, March 2, 2004; 109(8): 942 - 950.