spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Brennan, C. A.
Right arrow Articles by Moses, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Brennan, C. A.
Right arrow Articles by Moses, K.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Development, Vol 128, Issue 1 1-11, Copyright © 2001 by Company of Biologists

JOURNAL ARTICLES

Broad-complex, but not ecdysone receptor, is required for progression of the morphogenetic furrow in the Drosophila eye

CA Brennan, TR Li, M Bender, F Hsiung and K Moses
Sloan-Kettering Institute, Box 193, New York, NY 10021, USA.

The progression of the morphogenetic furrow in the developing Drosophila eye is an early metamorphic, ecdysteroid-dependent event. Although Ecdysone receptor-encoded nuclear receptor isoforms are the only known ecdysteroid receptors, we show that the Ecdysone receptor gene is not required for furrow function. DHR78, which encodes another candidate ecdysteroid receptor, is also not required. In contrast, zinc finger-containing isoforms encoded by the early ecdysone response gene Broad-complex regulate furrow progression and photoreceptor specification. br-encoded Broad-complex subfunctions are required for furrow progression and proper R8 specification, and are antagonized by other subfunctions of Broad-complex. There is a switch from Broad complex Z2 to Z1 zinc-finger isoform expression at the furrow which requires Z2 expression and responds to Hedgehog signals. These results suggest that a novel hormone transduction hierarchy involving an uncharacterized receptor operates in the eye disc.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 DevelopmentHome page
N. Mitchell, N. Cranna, H. Richardson, and L. Quinn
The Ecdysone-inducible zinc-finger transcription factor Crol regulates Wg transcription and cell cycle progression in Drosophila
Development, August 15, 2008; 135(16): 2707 - 2716.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
B. Konopova and M. Jindra
Broad-Complex acts downstream of Met in juvenile hormone signaling to coordinate primitive holometabolan metamorphosis
Development, February 1, 2008; 135(3): 559 - 568.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. Schubiger, C. Carre, C. Antoniewski, and J. W. Truman
Ligand-dependent de-repression via EcR/USP acts as a gate to coordinate the differentiation of sensory neurons in the Drosophila wing
Development, December 1, 2005; 132(23): 5239 - 5248.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
D. P. Srivastava, E. J. Yu, K. Kennedy, H. Chatwin, V. Reale, M. Hamon, T. Smith, and P. D. Evans
Rapid, Nongenomic Responses to Ecdysteroids and Catecholamines Mediated by a Novel Drosophila G-Protein-Coupled Receptor
J. Neurosci., June 29, 2005; 25(26): 6145 - 6155.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
X. Zhou, B. Zhou, J. W. Truman, and L. M. Riddiford
Overexpression of broad: a new insight into its role in the Drosophila prothoracic gland cells
J. Exp. Biol., March 1, 2004; 207(7): 1151 - 1161.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Uhlirova, B. D. Foy, B. J. Beaty, K. E. Olson, L. M. Riddiford, and M. Jindra
Use of Sindbis virus-mediated RNA interference to demonstrate a conserved role of Broad-Complex in insect metamorphosis
PNAS, December 23, 2003; 100(26): 15607 - 15612.
[Abstract] [Full Text] [PDF]

Home page
 Integr. Comp. Biol.Home page
M. Friedrich
Evolution of Insect Eye Development: First Insights from Fruit Fly, Grasshopper and Flour Beetle
Integr. Comp. Biol., August 1, 2003; 43(4): 508 - 521.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
L. Cherbas, X. Hu, I. Zhimulev, E. Belyaeva, and P. Cherbas
EcR isoforms in Drosophila: testing tissue-specific requirements by targeted blockade and rescue
Development, March 2, 2003; 130(2): 271 - 284.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. W. Kim, X. Fang, H. Ji, A. F. Paulson, J. M. Daniel, M. Ciesiolka, F. van Roy, and P. D. McCrea
Isolation and Characterization of XKaiso, a Transcriptional Repressor That Associates with the Catenin Xp120ctn in Xenopus laevis
J. Biol. Chem., March 1, 2002; 277(10): 8202 - 8208.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
X. Zhou and L. M. Riddiford
Broad specifies pupal development and mediates the 'status quo' action of juvenile hormone on the pupal-adult transformation in Drosophila and Manduca
Development, January 5, 2002; 129(9): 2259 - 2269.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
J Treisman
Drosophila homologues of the transcriptional coactivation complex subunits TRAP240 and TRAP230 are required for identical processes in eye-antennal disc development
Development, January 2, 2001; 128(4): 603 - 615.
[Abstract] [PDF]


© The Company of Biologists Ltd 2001