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Development, Vol 128, Issue 10 1817-1830, Copyright © 2001 by Company of Biologists

JOURNAL ARTICLES

Germline and developmental roles of the nuclear transport factor importin (&agr;)3 in C. elegans

KG Geles and SA Adam
Department of Cell and Molecular Biology and the Robert H. Lurie Comprehensive Cancer Center, Northwestern University Medical School, Chicago, IL 60611, USA. s-adam@northwestern.edu

The importin (&agr;) family of transport factors mediates the nuclear import of classical nuclear localization signal-containing proteins. In order to understand how multiple importin (&agr;) proteins are regulated both in individual cells and in a whole organism, the three importin (&agr;) (ima) genes of Caenorhabditis elegans have been identified and studied. All three IMAs are expressed in the germline; however, only IMA-3 is expressed in the soma. RNA interference (RNAi) experiments demonstrate that IMA-3 is required for the progression of meiotic prophase I during oocyte development. Loss of IMA-3 expression leads also to a disruption of the nuclear pore complex accompanied by the mis-localization of P granules. A range of defects occurring in ima-3(RNAi) F(1) progeny further supports a role for IMA-3 during embryonic and larval development. The functional association of IMA-3 with distinct cellular events, its expression pattern and intracellular localization indicate that regulation of the nuclear transport machinery is involved in the control of developmental pathways.


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