|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway, NJ 08854, USA
Accepted April 5, 2001
fringe encodes a glycosyltransferase that modulates the ability of the Notch receptor to be activated by its ligands. We describe studies of fringe function during early stages of Drosophila oogenesis. Animals mutant for hypomorphic alleles of fringe contain follicles with an incorrect number of germline cells, which are separated by abnormally long and disorganized stalks. Analysis of clones of somatic cells mutant for a null allele of fringe localizes the requirement for fringe in follicle formation to the polar cells, and demonstrates that fringe is required for polar cell fate. Clones of cells mutant for Notch also lack polar cells and the requirement for Notch in follicle formation appears to map to the polar cells. Ectopic expression of fringe or of an activated form of Notch can generate an extra polar cell. Our results indicate that fringe plays a key role in positioning Notch activation during early oogenesis, and establish a function for the polar cells in separating germline cysts into individual follicles.
Key words: fringe, Notch, Polar cells, Oogenesis, Follicle cells, Egg chamber, Drosophila
This article has been cited by other articles:
|
|
 |
|
  K. Sato, T. M. Matsunaga, R. Futahashi, T. Kojima, K. Mita, Y. Banno, and H. Fujiwara Positional Cloning of a Bombyx Wingless Locus flugellos (fl) Reveals a Crucial Role for fringe That Is Specific for Wing Morphogenesis Genetics, June 1, 2008; 179(2): 875 - 885. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Grammont and K. D. Irvine Organizer activity of the polar cells during Drosophila oogenesis Development, March 13, 2003; 129(22): 5131 - 5140. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Peri, M. Technau, and S. Roth Mechanisms of Gurken-dependent pipe regulation and the robustness of dorsoventral patterning in Drosophila Development, March 8, 2003; 129(12): 2965 - 2975. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Besse and A.-M. Pret Apoptosis-mediated cell death within the ovarian polar cell lineage of Drosophila melanogaster Development, March 1, 2003; 130(5): 1017 - 1027. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Besse, D. Busson, and A.-M. Pret Fused-dependent Hedgehog signal transduction is required for somatic cell differentiation during Drosophila egg chamber formation Development, September 1, 2002; 129(17): 4111 - 4124. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Bai and D. Montell Eyes Absent, a key repressor of polar cell fate during Drosophila oogenesis Development, January 12, 2002; 129(23): 5377 - 5388. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Smith III, C. A. Cummings, and C. Cronmiller daughterless coordinates somatic cell proliferation, differentiation and germline cyst survival during follicle formation in Drosophila Development, January 7, 2002; 129(13): 3255 - 3267. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. McGregor, R. Xi, and D. A. Harrison JAK signaling is somatically required for follicle cell differentiation in Drosophila Development, January 2, 2002; 129(3): 705 - 717. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Chen, D. J. Moloney, and P. Stanley Fringe modulation of Jagged1-induced Notch signaling requires the action of beta 4galactosyltransferase-1 PNAS, November 9, 2001; (2001) 241398098. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Chen, D. J. Moloney, and P. Stanley Fringe modulation of Jagged1-induced Notch signaling requires the action of beta 4galactosyltransferase-1 PNAS, November 20, 2001; 98(24): 13716 - 13721. [Abstract] [Full Text] [PDF]
|
|
