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Development 128, 2269-2279 (2001)
© 2001 The Company of Biologists Limited

Fate map of early avian cardiac progenitor cells

Abhay Redkar1, Michael Montgomery1 and Judith Litvin1,2,*

1 Department of Anatomy and Cell Biology, Temple University School of Medicine, Philadelphia, PA 19140, USA
2 Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19140, USA

*Author for correspondence (e-mail: jl1{at}astro.ocis.temple.edu)

Accepted March 26, 2001

Cardiogenic fate maps are used to address questions on commitment, differentiation, morphogenesis and organogenesis of the heart. Recently, the accuracy of classical cardiogenic fate maps has been questioned, raising concerns about the conclusions drawn in studies based on these maps. We present accurate fate maps of the heart-forming region (HFR) in avian embryos and show that the putative cardiogenic molecular markers Bmp2 and Nkx2.5 do not govern the boundaries of the HFR as suggested in the literature. Moreover, this paper presents the first fate map of the HFR at stage 4 and addresses a void in the literature concerning rostrocaudal patterning of heart cells between stages 4 and 8.

Key words: Fate map, Heart-forming region, Bmp2, Nkx2.5, Chick




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© The Company of Biologists Ltd 2001