spacer gif spacer gif spacer gif spacer gif spacer gif
 QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    


This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Schneider, R. A.
Right arrow Articles by Helms, J. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Schneider, R. A.
Right arrow Articles by Helms, J. A.
Social Bookmarking
 Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?
Development 128, 2755-2767 (2001)
© 2001 The Company of Biologists Limited

Local retinoid signaling coordinates forebrain and facial morphogenesis by maintaining FGF8 and SHH

Richard A. Schneider1,*, Diane Hu1,*, John L. R. Rubenstein2, Malcolm Maden3 and Jill A. Helms1,{ddagger}

1 Department of Orthopaedic Surgery, 533 Parnassus Avenue, Suite U-453, University of California at San Francisco, San Francisco, CA 94143-0514, USA
2 Department of Psychiatry, Nina Ireland Lab of Developmental Neurobiology, University of California at San Francisco, San Francisco, CA 94143, USA
3 MRC Centre for Developmental Neurobiology, King’s College London, Guy’s Campus, London Bridge, London SE1 9RT, UK
* These authors contributed equally to this work

{ddagger}Author for correspondence (e-mail: helms{at}cgl.ucsf.edu)

Accepted April 2, 2001

Correlations between facial anomalies and brain defects are well characterized throughout the clinical literature, yet a developmental basis for this association has not been identified. We demonstrate that the frontonasal process, which gives rise to the mid- and upper face, and the forebrain are linked early in their morphogenesis by a local retinoid signaling event that maintains the expression of key regulatory molecules. First, we show that aldehyde dehydrogenase 6, which synthesizes the ligand, retinoic acid, is localized to the ventral epithelium of the presumptive frontonasal process of chick embryos. At least two retinoid receptors are expressed in adjacent populations of mesenchyme. Second, using synthetic pan-specific retinoid antagonists, we transiently inhibit the ability of retinoid receptors to bind retinoic acid in the rostral head and we generate embryos with a hypoplastic forebrain, fused eyes, and no frontonasal process-derived structures such as the upper beak. These defects are not due to eliminating mesenchymal progenitors, as neural crest cells still migrate into the frontonasal process, despite disruptions to retinoid signaling. Rather, these malformations result from loss of fibroblast growth factor 8 and sonic hedgehog expression, which leads to increased programmed cell death and decreased proliferation in the forebrain and frontonasal process. Most significantly, we can rescue the morphological defects by re-introducing retinoic acid, or fibroblast growth factor and sonic hedgehog proteins into antagonist-treated embryos. We propose that the local source of retinoic acid in the rostral head initiates a regulatory cascade that coordinates forebrain and frontonasal process morphogenesis.

Key words: Craniofacial, Forebrain, Face, ALDH6, FGF8, SHH, Retinoic acid, Chick


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
Genes Dev.Home page
D. Maurus and W. A. Harris
Zic-associated holoprosencephaly: zebrafish Zic1 controls midline formation and forebrain patterning by regulating Nodal, Hedgehog, and retinoic acid signaling
Genes & Dev., June 15, 2009; 23(12): 1461 - 1473.
[Abstract] [Full Text] [PDF]


Home page
CSH ProtocolsHome page
A. Abzhanov
Darwin's Finches: Analysis of Beak Morphological Changes During Evolution
CSH Protocols, March 1, 2009; 2009(3): pdb.emo119 - pdb.emo119.
[Abstract] [Full Text]


Home page
JDRHome page
A.H. Jheon and R.A. Schneider
The Cells that Fill the Bill: Neural Crest and the Evolution of Craniofacial Development
Journal of Dental Research, January 1, 2009; 88(1): 12 - 21.
[Abstract] [Full Text] [PDF]


Home page
DevelopmentHome page
D. Hu and R. S. Marcucio
A SHH-responsive signaling center in the forebrain regulates craniofacial morphogenesis via the facial ectoderm
Development, January 1, 2009; 136(1): 107 - 116.
[Abstract] [Full Text] [PDF]


Home page
DevelopmentHome page
B. F. Eames and R. A. Schneider
The genesis of cartilage size and shape during development and evolution
Development, December 1, 2008; 135(23): 3947 - 3958.
[Abstract] [Full Text] [PDF]


Home page
J. Neurosci.Home page
E. S. Tucker, S. Segall, D. Gopalakrishna, Y. Wu, M. Vernon, F. Polleux, and A.-S. LaMantia
Molecular Specification and Patterning of Progenitor Cells in the Lateral and Medial Ganglionic Eminences
J. Neurosci., September 17, 2008; 28(38): 9504 - 9518.
[Abstract] [Full Text] [PDF]


Home page
DevelopmentHome page
H. Yanagisawa, D. E. Clouthier, J. A. Richardson, J. Charite, and E. N. Olson
Targeted deletion of a branchial arch-specific enhancer reveals a role of dHAND in craniofacial development
Development, March 15, 2003; 130(6): 1069 - 1078.
[Abstract] [Full Text] [PDF]


Home page
Genes Dev.Home page
M. M. Riccomagno, L. Martinu, M. Mulheisen, D. K. Wu, and D. J. Epstein
Specification of the mammalian cochlea is dependent on Sonic hedgehog
Genes & Dev., September 15, 2002; 16(18): 2365 - 2378.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
R. A. McCarthy, J. L. Barth, M. R. Chintalapudi, C. Knaak, and W. S. Argraves
Megalin Functions as an Endocytic Sonic Hedgehog Receptor
J. Biol. Chem., July 5, 2002; 277(28): 25660 - 25667.
[Abstract] [Full Text] [PDF]


Home page
DevelopmentHome page
N. B. David, L. Saint-Etienne, M. Tsang, T. F. Schilling, and F. M. Rosa
Requirement for endoderm and FGF3 in ventral head skeleton formation
Development, January 10, 2002; 129(19): 4457 - 4468.
[Abstract] [Full Text] [PDF]


Home page
DevelopmentHome page
L. Teboul, J. Hadchouel, P. Daubas, D. Summerbell, M. Buckingham, and P. W. J. Rigby
The early epaxial enhancer is essential for the initial expression of the skeletal muscle determination gene Myf5 but not for subsequent, multiple phases of somitic myogenesis
Development, January 10, 2002; 129(19): 4571 - 4580.
[Abstract] [Full Text] [PDF]


Home page
DevelopmentHome page
R. Abu-Issa, G. Smyth, I. Smoak, K.-i. Yamamura, and E. N. Meyers
Fgf8 is required for pharyngeal arch and cardiovascular development in the mouse
Development, January 10, 2002; 129(19): 4613 - 4625.
[Abstract] [Full Text] [PDF]




© The Company of Biologists Ltd 2001