spacer gif spacer gif spacer gif spacer gif spacer gif
 QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    


This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Feiner, L.
Right arrow Articles by Raper, J. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Feiner, L.
Right arrow Articles by Raper, J. A.
Social Bookmarking
 Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?
Development 128, 3061-3070 (2001)
© 2001 The Company of Biologists Limited

Targeted disruption of semaphorin 3C leads to persistent truncus arteriosus and aortic arch interruption

Leonard Feiner1, Andrea L. Webber1, Christopher B. Brown2, Min Min Lu2, Li Jia1, Paul Feinstein3, Peter Mombaerts3, Jonathan A. Epstein2 and Jonathan A. Raper1,*

1 Department of Neuroscience, University of Pennsylvania School of Medicine, 1115 BRB II/III, 421 Curie Blvd, Philadelphia, PA 19104, USA
2 Department of Medicine, Cardiovascular Division, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
3 The Rockefeller University, New York, New York 10021, USA
* Author for correspondence (e-mail:raperj{at}mail.med.upen.edu )

Accepted 31 May 2001

Semaphorin 3C is a secreted member of the semaphorin gene family. To investigate its function in vivo, we have disrupted the semaphorin 3C locus in mice by targeted mutagenesis. semaphorin 3C mutant mice die within hours after birth from congenital cardiovascular defects consisting of interruption of the aortic arch and improper septation of the cardiac outflow tract. This phenotype is similar to that reported following ablation of the cardiac neural crest in chick embryos and resembles congenital heart defects seen in humans. Semaphorin 3C is expressed in the cardiac outflow tract as neural crest cells migrate into it. Their entry is disrupted in semaphorin 3C mutant mice. These data suggest that semaphorin 3C promotes crest cell migration into the proximal cardiac outflow tract.

Key words: Semaphorin 3C, Mouse, Cardiac neural crest, Interrupted aortic arch, Persistent truncus arteriosus, PlexinA2, Chemoattractant, Sema3C


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
DevelopmentHome page
A. Calmont, S. Ivins, K. L. Van Bueren, I. Papangeli, V. Kyriakopoulou, W. D. Andrews, J. F. Martin, A. M. Moon, E. A. Illingworth, M. A. Basson, et al.
Tbx1 controls cardiac neural crest cell migration during arch artery development by regulating Gbx2 expression in the pharyngeal ectoderm
Development, September 15, 2009; 136(18): 3173 - 3183.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
K. Kodo, T. Nishizawa, M. Furutani, S. Arai, E. Yamamura, K. Joo, T. Takahashi, R. Matsuoka, and H. Yamagishi
GATA6 mutations cause human cardiac outflow tract defects by disrupting semaphorin-plexin signaling
PNAS, August 18, 2009; 106(33): 13933 - 13938.
[Abstract] [Full Text] [PDF]


Home page
Cereb CortexHome page
M. Piper, C. Plachez, O. Zalucki, T. Fothergill, G. Goudreau, R. Erzurumlu, C. Gu, and L. J. Richards
Neuropilin 1-Sema Signaling Regulates Crossing of Cingulate Pioneering Axons during Development of the Corpus Callosum
Cereb Cortex, July 1, 2009; 19(suppl_1): i11 - i21.
[Abstract] [Full Text] [PDF]


Home page
Circ. Res.Home page
F. Rochais, K. Mesbah, and R. G. Kelly
Signaling Pathways Controlling Second Heart Field Development
Circ. Res., April 24, 2009; 104(8): 933 - 942.
[Abstract] [Full Text] [PDF]


Home page
Physiol. Rev.Home page
B. Turgeon and S. Meloche
Interpreting Neonatal Lethal Phenotypes in Mouse Mutants: Insights Into Gene Function and Human Diseases
Physiol Rev, January 1, 2009; 89(1): 1 - 26.
[Abstract] [Full Text] [PDF]


Home page
Circ. Res.Home page
Y. Morikawa and P. Cserjesi
Cardiac Neural Crest Expression of Hand2 Regulates Outflow and Second Heart Field Development
Circ. Res., December 5, 2008; 103(12): 1422 - 1429.
[Abstract] [Full Text] [PDF]


Home page
Circ. Res.Home page
K. Stankunas, C. Shang, K. Y. Twu, S.-C. Kao, N. A. Jenkins, N. G. Copeland, M. Sanyal, L. Selleri, M. L. Cleary, and C.-P. Chang
Pbx/Meis Deficiencies Demonstrate Multigenetic Origins of Congenital Heart Disease
Circ. Res., September 26, 2008; 103(7): 702 - 709.
[Abstract] [Full Text] [PDF]


Home page
Circ. Res.Home page
A. Salikhova, L. Wang, A. A. Lanahan, M. Liu, M. Simons, W. P. J. Leenders, D. Mukhopadhyay, and A. Horowitz
Vascular Endothelial Growth Factor and Semaphorin Induce Neuropilin-1 Endocytosis via Separate Pathways
Circ. Res., September 12, 2008; 103(6): e71 - e79.
[Abstract] [Full Text] [PDF]


Home page
Circ. Res.Home page
M. L. Kirby
Pulmonary Atresia or Persistent Truncus Arteriosus: Is It Important to Make the Distinction and How Do We Do It?
Circ. Res., August 15, 2008; 103(4): 337 - 339.
[Full Text] [PDF]


Home page
Circ. Res.Home page
M. Theveniau-Ruissy, M. Dandonneau, K. Mesbah, O. Ghez, M.-G. Mattei, L. Miquerol, and R. G. Kelly
The del22q11.2 Candidate Gene Tbx1 Controls Regional Outflow Tract Identity and Coronary Artery Patterning
Circ. Res., July 18, 2008; 103(2): 142 - 148.
[Abstract] [Full Text] [PDF]


Home page
Circ. Res.Home page
D. G.M. Molin, R. E. Poelmann, M. C. DeRuiter, M. Azhar, T. Doetschman, and A. C. Gittenberger-de Groot
Transforming Growth Factor {beta}-SMAD2 Signaling Regulates Aortic Arch Innervation and Development
Circ. Res., November 26, 2004; 95(11): 1109 - 1117.
[Abstract] [Full Text] [PDF]


Home page
JDRHome page
T.E. Lallier
Semaphorin Profiling of Periodontal Fibroblasts and Osteoblasts
Journal of Dental Research, September 1, 2004; 83(9): 677 - 682.
[Abstract] [Full Text] [PDF]


Home page
Circ. Res.Home page
H. S. Baldwin
Only Our Patients Know for Sure
Circ. Res., June 11, 2004; 94(11): 1401 - 1402.
[Full Text] [PDF]


Home page
Circ. Res.Home page
P. J. Gruber and J. A. Epstein
Development Gone Awry: Congenital Heart Disease
Circ. Res., February 20, 2004; 94(3): 273 - 283.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
C. Gu, B. J. Limberg, G. B. Whitaker, B. Perman, D. J. Leahy, J. S. Rosenbaum, D. D. Ginty, and A. L. Kolodkin
Characterization of Neuropilin-1 Structural Features That Confer Binding to Semaphorin 3A and Vascular Endothelial Growth Factor 165
J. Biol. Chem., May 10, 2002; 277(20): 18069 - 18076.
[Abstract] [Full Text] [PDF]


Home page
DevelopmentHome page
C. Liu, W. Liu, J. Palie, M. F. Lu, N. A. Brown, and J. F. Martin
Pitx2c patterns anterior myocardium and aortic arch vessels and is required for local cell movement into atrioventricular cushions
Development, January 11, 2002; 129(21): 5081 - 5091.
[Abstract] [Full Text] [PDF]


Home page
DevelopmentHome page
D. U. Frank, L. K. Fotheringham, J. A. Brewer, L. J. Muglia, M. Tristani-Firouzi, M. R. Capecchi, and A. M. Moon
An Fgf8 mouse mutant phenocopies human 22q11 deletion syndrome
Development, January 10, 2002; 129(19): 4591 - 4603.
[Abstract] [Full Text] [PDF]


Home page
Cold Spring Harb Symp Quant BiolHome page
A.D. GITLER, C.B. BROWN, L. KOCHILAS, J. LI, and J.A. EPSTEIN
Neural Crest Migration and Mouse Models of Congenital Heart Disease
Cold Spring Harb Symp Quant Biol, January 1, 2002; 67(0): 57 - 62.
[Abstract] [PDF]


Home page
DevelopmentHome page
C. B. Brown, L. Feiner, M.-M. Lu, J. Li, X. Ma, A. L. Webber, L. Jia, J. A. Raper, and J. A. Epstein
PlexinA2 and semaphorin signaling during cardiac neural crest development
Development, August 15, 2001; 128(16): 3071 - 3080.
[Abstract] [Full Text] [PDF]




© The Company of Biologists Ltd 2001