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Development 128, 3233-3242 (2001)
© 2001 The Company of Biologists Limited

Me31B silences translation of oocyte-localizing RNAs through the formation of cytoplasmic RNP complex during Drosophila oogenesis

Akira Nakamura1,2, Reiko Amikura1,*, Kazuko Hanyu1 and Satoru Kobayashi1,2,*,{ddagger}

1 Institute of Biological Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8572, Japan
2 Gene Experiment Center, University of Tsukuba, Tsukuba, Ibaraki 305-8572, Japan
* Present address: Center for Integrative Bioscience, Okazaki National Research Institutes, Okazaki, Aichi 444-8585, Japan

{ddagger}Author for correspondence (skob{at}nibb.ac.jp)

Accepted May 15, 2001

Embryonic patterning in Drosophila is regulated by maternal factors. Many such factors become localized as mRNAs within the oocyte during oogenesis and are translated in a spatio-temporally regulated manner. These processes are controlled by trans-acting proteins, which bind to the target RNAs to form a ribonucleoprotein (RNP) complex. We report that a DEAD-box protein, Me31B, forms a cytoplasmic RNP complex with oocyte-localizing RNAs and Exuperantia, a protein involved in RNA localization. During early oogenesis, loss of Me31B causes premature translation of oocyte-localizing RNAs within nurse cells, without affecting their transport to the oocyte. These results suggest that Me31B mediates translational silencing of RNAs during their transport to the oocyte. Our data provide evidence that RNA transport and translational control are linked through the assembly of RNP complex.

Key words: Drosophila, Maternal RNA, RNA transport, RNA masking, RNP complex, Translational control


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© The Company of Biologists Ltd 2001