spacer gif spacer gif spacer gif spacer gif ARCHIVE ANNOUNCEMENT! spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Milán, M.
Right arrow Articles by Cohen, S. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Milán, M.
Right arrow Articles by Cohen, S. M.
Development 128, 3263-3268 (2001)
© 2001 The Company of Biologists Limited

msh specifies dorsal cell fate in the Drosophila wing

Marco Milán1,*, Ulrich Weihe1,*, Stanley Tiong2,{ddagger}, Welcome Bender2 and Stephen M. Cohen1,§

1 European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
2 Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA
{ddagger} Present address: Exilixis Inc., 170 Harbor Way, PO Box 511, South San Francisco, CA 94083-0511, USA
* These authors contributed equally to the work

§Author for correspondence (e-mail: cohen{at}embl-heidelberg.de)

Accepted June 11, 2001

Drosophila limbs develop from imaginal discs that are subdivided into compartments. Dorsal-ventral subdivision of the wing imaginal disc depends on apterous activity in dorsal cells. Apterous protein is expressed in dorsal cells and is responsible for (1) induction of a signaling center along the dorsal-ventral compartment boundary (2) establishment of a lineage restriction boundary between compartments and (3) specification of dorsal cell fate. Here, we report that the homeobox gene msh (muscle segment homeobox) acts downstream of apterous to confer dorsal identity in wing development.

Key words: msh, apterous, Differentiation, Identity, Selector gene, Drosophila melanogaster, Wing, Dorsoventral patterning




This article has been cited by other articles:


Home page
 GeneticsHome page
F. Bejarano, C. M. Luque, H. Herranz, G. Sorrosal, N. Rafel, T. T. Pham, and M. Milan
A Gain-of-Function Suppressor Screen for Genes Involved in Dorsal-Ventral Boundary Formation in the Drosophila Wing
Genetics, January 1, 2008; 178(1): 307 - 323.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
D. J. van Meyel, J. B. Thomas, and A. D. Agulnick
Ssdp proteins bind to LIM-interacting co-factors and regulate the activity of LIM-homeodomain protein complexes in vivo
Development, May 1, 2003; 130(9): 1915 - 1925.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
U. Weihe, M. Milan, and S. M. Cohen
Regulation of Apterous activity in Drosophila wing development
Development, November 15, 2001; 128(22): 4615 - 4622.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2001