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Development 128, 3307-3319 (2001)
© 2001 The Company of Biologists Limited

Headless flies generated by developmental pathway interference

Renjie Jiao*, Michael Daube, Hong Duan{ddagger}, Yu Zou, Erich Frei and Markus Noll§

Institute for Molecular Biology, University of Zürich, Winterthurerstr. 190, CH-8057 Zürich, Switzerland
* Present address: Institute of Veterinary Biochemistry, University of Zürich, Winterthurerstr. 190, CH-8057 Zürich, Switzerland
{ddagger} Present address: Department of Medicine, Division of Cardiology, Albert Einstein College of Medicine, Bronx, NY 10461, USA

§Author for correspondence (e-mail: noll{at}molbio.unizh.ch)

Accepted June 7, 2001

Ectopic expression of transcription factors in eye-antennal discs of Drosophila strongly interferes with their developmental program. Early ectopic expression in embryonic discs interferes with the developmental pathway primed by Eyeless and generates headless flies, which suggests that Eyeless is necessary for initiating cell proliferation and development of both the eye and antennal disc. Interference occurs through a block in the cell cycle that for some ectopic transcription factors is overcome by D-CycE or D-Myc. Late ectopic expression in cone cell precursors interferes with their differentiation. We propose that this developmental pathway interference is a general surveillance mechanism that eliminates most aberrations in the genetic program during development and evolution, and thus seriously restricts the pathways that evolution may take.

Key words: Developmental pathway interference, eyeless, Headless, Evolution, Drosophila


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© The Company of Biologists Ltd 2001