|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Institute for Molecular Biology, University of Zürich, Winterthurerstr. 190, CH-8057 Zürich, Switzerland
* Present address: Institute of Veterinary Biochemistry, University of Zürich, Winterthurerstr. 190, CH-8057 Zürich, Switzerland
Present address: Department of Medicine, Division of Cardiology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Author for correspondence (e-mail: noll{at}molbio.unizh.ch)
Accepted June 7, 2001
Ectopic expression of transcription factors in eye-antennal discs of Drosophila strongly interferes with their developmental program. Early ectopic expression in embryonic discs interferes with the developmental pathway primed by Eyeless and generates headless flies, which suggests that Eyeless is necessary for initiating cell proliferation and development of both the eye and antennal disc. Interference occurs through a block in the cell cycle that for some ectopic transcription factors is overcome by D-CycE or D-Myc. Late ectopic expression in cone cell precursors interferes with their differentiation. We propose that this developmental pathway interference is a general surveillance mechanism that eliminates most aberrations in the genetic program during development and evolution, and thus seriously restricts the pathways that evolution may take.
Key words: Developmental pathway interference, eyeless, Headless, Evolution, Drosophila
This article has been cited by other articles:
|
|
 |
|
  L. R. Braid and E. M. Verheyen Drosophila Nemo Promotes Eye Specification Directed by the Retinal Determination Gene Network Genetics, September 1, 2008; 180(1): 283 - 299. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Savare, N. Bonneaud, and F. Girard SUMO Represses Transcriptional Activity of the Drosophila SoxNeuro and Human Sox3 Central Nervous System-specific Transcription Factors Mol. Biol. Cell, June 1, 2005; 16(6): 2660 - 2669. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Szuplewski, B. Kottler, and R. Terracol The Drosophila bZIP transcription factor Vrille is involved in hair and cell growth Development, August 15, 2003; 130(16): 3651 - 3662. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-C. Jang, J.-L. Chao, N. Jones, L.-C. Yao, D. A. Bessarab, Y. M. Kuo, S. Jun, C. Desplan, S. K. Beckendorf, and Y. H. Sun Two Pax genes, eye gone and eyeless, act cooperatively in promoting Drosophila eye development Development, July 1, 2003; 130(13): 2939 - 2951. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Kronhamn, E. Frei, M. Daube, R. Jiao, Y. Shi, M. Noll, and A. Rasmuson-Lestander Headless flies produced by mutations in the paralogous Pax6 genes eyeless and twin of eyeless Development, March 4, 2003; 129(4): 1015 - 1026. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Xue and M. Noll Dual role of the Pax gene paired in accessory gland development of Drosophila Development, March 3, 2003; 129(2): 339 - 346. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Benassayag, S. Plaza, P. Callaerts, J. Clements, Y. Romeo, W. J. Gehring, and D. L. Cribbs Evidence for a direct functional antagonism of the selector genes proboscipedia and eyeless in Drosophila head development Development, February 1, 2003; 130(3): 575 - 586. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A.-S. K. Tseng and I. K. Hariharan An Overexpression Screen in Drosophila for Genes That Restrict Growth or Cell-Cycle Progression in the Developing Eye Genetics, September 1, 2002; 162(1): 229 - 243. [Abstract] [Full Text] [PDF]
|
|
