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four-jointed interacts with dachs, abelson and enabled and feeds back onto the Notch pathway to affect growth and segmentation in the Drosophila leg

Gerri R. Buckles¹, Cordelia Rauskolb², John Lee Villano^1, and Flora N. Katz^1,*

¹ Department of Biology, Texas A&M University, College Station, TX 77843-3258, USA
² Waksman Institute, Rutgers, The State University, Piscataway, New Jersey 08854, USA
Present address: University of Chicago Medical Center, Section of Medicine, Department of Hematology/Oncology, 5841 South Maryland Ave, MC 2115, Chicago, IL 60627-1470, USA

*Author for correspondence (e-mail: fkatz{at}mail.bio.tamu.edu)

Accepted June 26, 2001

The molecular basis of segmentation and regional growth during morphogenesis of Drosophila legs is poorly understood. We show that four-jointed is not only required for these processes, but also can direct ectopic growth and joint initiation when its normal pattern of expression is disturbed. These effects are non-autonomous, consistent with our demonstration of both transmembrane and secreted forms of the protein in vivo. The similarities between four-jointed and Notch phenotypes led us to further investigate the relationships between these pathways. Surprisingly, we find that although four-jointed expression is regulated downstream of Notch activation, four-jointed can induce expression of the Notch ligands, Serrate and Delta, and may thereby participate in a feedback loop with the Notch signaling pathway. We also show that four-jointed interacts with abelson, enabled and dachs, which leads us to suggest that one target of four-jointed signaling is the actin cytoskeleton. Thus, four-jointed may bridge the gap between the signals that direct morphogenesis and those that carry it out.

Key words: Four-jointed, Abelson, Enabled, Dachs, Serrate, Delta, Leg segmentation, Drosophila melanogaster

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