spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lundquist, E. A.
Right arrow Articles by Bargmann, C. I.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lundquist, E. A.
Right arrow Articles by Bargmann, C. I.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?
Development 128, 4475-4488 (2001)
© 2001 The Company of Biologists Limited

Three C. elegans Rac proteins and several alternative Rac regulators control axon guidance, cell migration and apoptotic cell phagocytosis

Erik A. Lundquist1,*,{ddagger}, Peter W. Reddien2,*, Erika Hartwieg2, H. Robert Horvitz2 and Cornelia I. Bargmann3

1 Department of Molecular Biosciences, University of Kansas, 5049 Haworth Hall, 1200 Sunnyside Avenue, Lawrence, KS 66045, USA
2 Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
3 Howard Hughes Medical Institute, Department of Anatomy Box 0452, University of California, San Francisco, CA 94143, USA
* These authors contributed equally to this work

{ddagger}Author for correspondence (e-mail: erikl{at}ku.edu)

Accepted August 21, 2001

The Caenorhabditis elegans genome contains three rac-like genes, ced-10, mig-2, and rac-2. We report that ced-10, mig-2 and rac-2 act redundantly in axon pathfinding: inactivating one gene had little effect, but inactivating two or more genes perturbed both axon outgrowth and guidance. mig-2 and ced-10 also have redundant functions in some cell migrations. By contrast, ced-10 is uniquely required for cell-corpse phagocytosis, and mig-2 and rac-2 have only subtle roles in this process. Rac activators are also used differentially. The UNC-73 Trio Rac GTP exchange factor affected all Rac pathways in axon pathfinding and cell migration but did not affect cell-corpse phagocytosis. CED-5 DOCK180, which acts with CED-10 Rac in cell-corpse phagocytosis, acted with MIG-2 but not CED-10 in axon pathfinding. Thus, distinct regulatory proteins modulate Rac activation and function in different developmental processes.

Key words: C. elegans, Rac, ced-10, mig-2, rac-2, Axon pathfinding, Cell migration, Phagocytosis


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
J. Samann, J. Hegermann, E. von Gromoff, S. Eimer, R. Baumeister, and E. Schmidt
Caenorhabditits elegans LRK-1 and PINK-1 Act Antagonistically in Stress Response and Neurite Outgrowth
J. Biol. Chem., June 12, 2009; 284(24): 16482 - 16491.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
S. Corbetta, S. Gualdoni, G. Ciceri, M. Monari, E. Zuccaro, V. L. J. Tybulewicz, and I. de Curtis
Essential role of Rac1 and Rac3 GTPases in neuronal development
FASEB J, May 1, 2009; 23(5): 1347 - 1357.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
P. J. Vanderzalm, A. Pandey, M. E. Hurwitz, L. Bloom, H. R. Horvitz, and G. Garriga
C. elegans CARMIL negatively regulates UNC-73/Trio function during neuronal development
Development, April 1, 2009; 136(7): 1201 - 1210.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
K. L. Schmidt, N. Marcus-Gueret, A. Adeleye, J. Webber, D. Baillie, and E. G. Stringham
The cell migration molecule UNC-53/NAV2 is linked to the ARP2/3 complex by ABI-1
Development, February 15, 2009; 136(4): 563 - 574.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
B. Salhia, N. L. Tran, A. Chan, A. Wolf, M. Nakada, F. Rutka, M. Ennis, W. S. McDonough, M. E. Berens, M. Symons, et al.
The Guanine Nucleotide Exchange Factors Trio, Ect2, and Vav3 Mediate the Invasive Behavior of Glioblastoma
Am. J. Pathol., December 1, 2008; 173(6): 1828 - 1838.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
M. A. Shakir, K. Jiang, E. C. Struckhoff, R. S. Demarco, F. B. Patel, M. C. Soto, and E. A. Lundquist
The Arp2/3 Activators WAVE and WASP Have Distinct Genetic Interactions With Rac GTPases in Caenorhabditis elegans Axon Guidance
Genetics, August 1, 2008; 179(4): 1957 - 1971.
[Abstract] [Full Text] [PDF]

Home page
 NeuroscientistHome page
C. A. Rabiner, R. E. Mains, and B. A. Eipper
Kalirin: A Dual Rho Guanine Nucleotide Exchange Factor That Is So Much More Than the Sum of Its Many Parts
Neuroscientist, April 1, 2005; 11(2): 148 - 160.
[Abstract] [PDF]

Home page
 DevelopmentHome page
E. C. Struckhoff and E. A. Lundquist
The actin-binding protein UNC-115 is an effector of Rac signaling during axon pathfinding in C. elegans
Development, February 15, 2003; 130(4): 693 - 704.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
M. C. Soto, H. Qadota, K. Kasuya, M. Inoue, D. Tsuboi, C. C. Mello, and K. Kaibuchi
The GEX-2 and GEX-3 proteins are required for tissue morphogenesis and cell migrations in C. elegans
Genes & Dev., March 1, 2002; 16(5): 620 - 632.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2001