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Development 128, 4615-4622 (2001)
© 2001 The Company of Biologists Limited

Regulation of Apterous activity in Drosophila wing development

Ulrich Weihe, Marco Milán and Stephen M. Cohen*

European Molecular Biology Laboratory, Meyerhofstr 1, 69117 Heidelberg, Germany

*Author for correspondence (e-mail: cohen{at}embl-heidelberg.de)

Accepted August 24, 2001

Apterous is a LIM-homeodomain protein that confers dorsal compartment identity in Drosophila wing development. Apterous activity requires formation of a complex with a co-factor, Chip/dLDB. Apterous activity is regulated during wing development by dLMO, which competes with Apterous for complex formation. Here, we present evidence that complex formation between Apterous, Chip and DNA stabilizes Apterous protein in vivo. We also report that a difference in the ability of Chip to bind the LIM domains of Apterous and dLMO contributes to regulation of activity levels in vivo.

Key words: Apterous, dLMO, Homeodomain, LIM domain, Wing development




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© The Company of Biologists Ltd 2001