|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Howard Hughes Medical Institute, Department of Molecular, Cellular and Developmental Biology, University of Colorado at Boulder, Boulder, CO 80309, USA
*Author for correspondence (e-mail: mhan{at}colorado.edu)
Accepted September 10, 2001
Vulval differentiation in Caenorhabditis elegans involves several fundamental cellular events, including cell fusion, division and migration. We have characterized the role of the lin-40 (also known as egr-1) gene in these cellular processes. LIN-40 is homologous to the metastasis-associated factor 1 (MTA1) in mammals, which has been identified as a component of the nucleosome remodeling and histone deacetylation (NuRD) complex that functions as a transcriptional co-repressor. We show here that lin-40 negatively regulates vulval fate specification at least partly by promoting cell fusion between the vulval precursor cells and the hypodermal syncytium at an early larval stage. This inhibitory function of lin-40 might be carried out by downregulating lin-39 Hox expression. We also show that lin-40 is specifically required for cell divisions along the transverse orientation during vulval morphogenesis.
Key words: lin-40 MTA, lin-39 Hox, VPCs competence, Vulval induction, Morphogenesis, Division orientation, C. elegans
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  S. Schott, F. Ramos, V. Coustham, and F. Palladino HPL-2/HP1 Prevents Inappropriate Vulval Induction in Caenorhabditis elegans by Acting in Both HYP7 and Vulval Precursor Cells Genetics, February 1, 2009; 181(2): 797 - 801. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Manavathi, S. Peng, S. K. Rayala, A. H. Talukder, M. H. Wang, R.-A. Wang, S. Balasenthil, N. Agarwal, L. J. Frishman, and R. Kumar Repression of Six3 by a corepressor regulates rhodopsin expression PNAS, August 7, 2007; 104(32): 13128 - 13133. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. W. Reddien, E. C. Andersen, M. C. Huang, and H. R. Horvitz DPL-1 DP, LIN-35 Rb and EFL-1 E2F Act With the MCD-1 Zinc-Finger Protein to Promote Programmed Cell Death in Caenorhabditis elegans Genetics, April 1, 2007; 175(4): 1719 - 1733. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Manavathi and R. Kumar Metastasis Tumor Antigens, an Emerging Family of Multifaceted Master Coregulators J. Biol. Chem., January 19, 2007; 282(3): 1529 - 1533. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Tucker, M. Sieber, M. Morphew, and M. Han The Caenorhabditis elegans aristaless Orthologue, alr-1, Is Required for Maintaining the Functional and Structural Integrity of the Amphid Sensory Organs Mol. Biol. Cell, October 1, 2005; 16(10): 4695 - 4704. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Yang, M. Sym, and C. Kenyon The roles of two C. elegans HOX co-factor orthologs in cell migration and vulva development Development, March 15, 2005; 132(6): 1413 - 1428. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Chen, D. J. Eastburn, and M. Han The Caenorhabditis elegans Nuclear Receptor Gene nhr-25 Regulates Epidermal Cell Development Mol. Cell. Biol., September 1, 2004; 24(17): 7345 - 7358. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Andachi Caenorhabditis elegans T-box genes tbx-9 and tbx-8 are required for formation of hypodermis and body-wall muscle in embryogenesis Genes Cells, April 1, 2004; 9(4): 331 - 344. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Dufourcq, M. Victor, F. Gay, D. Calvo, J. Hodgkin, and Y. Shi Functional Requirement for Histone Deacetylase 1 in Caenorhabditis elegans Gonadogenesis Mol. Cell. Biol., May 1, 2002; 22(9): 3024 - 3034. [Abstract] [Full Text] [PDF]
|
|
