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Development, Vol 128, Issue 4 551-560, Copyright © 2001 by Company of Biologists

JOURNAL ARTICLES

The Wnt-activated Xiro1 gene encodes a repressor that is essential for neural development and downregulates Bmp4

J Gomez-Skarmeta, E de La Calle-Mustienes and J Modolell
Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas and Universidad Autonoma de Madrid, Cantoblanco, Spain. jlgomez@cbm.uam.es

In the early Xenopus embryo, the Xiro homeodomain proteins of the Iroquois (Iro) family control the expression of proneural genes and the size of the neural plate. We report that Xiro1 functions as a repressor that is strictly required for neural differentiation, even when the BMP4 pathway is impaired. We also show that Xiro1 and Bmp4 repress each other. Consistently, Xiro1 and Bmp4 have complementary patterns of expression during gastrulation. The expression of Xiro1 requires Wnt signaling. Thus, Xiro1 is probably a mediator of the known downregulation of Bmp4 by Wnt signaling.


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© The Company of Biologists Ltd 2001