|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 128, Issue 5 711-722, Copyright © 2001 by Company of Biologists
JOURNAL ARTICLES |
TE Rusten, R Cantera, J Urban, G Technau, FC Kafatos and R Barrio
European Molecular Biology Laboratory, Meyerhofstrasse, D-69117 Heidelberg, Germany.
Genes of the spalt family encode nuclear zinc finger proteins. In Drosophila melanogaster, they are necessary for the establishment of head/trunk identity, correct tracheal migration and patterning of the wing imaginal disc. Spalt proteins display a predominant pattern of expression in the nervous system, not only in Drosophila but also in species of fish, mouse, frog and human, suggesting an evolutionarily conserved role for these proteins in nervous system development. Here we show that Spalt works as a cell fate switch between two EGFR-induced cell types, the oenocytes and the precursors of the pentascolopodial organ in the embryonic peripheral nervous system. We show that removal of spalt increases the number of scolopodia, as a result of extra secondary recruitment of precursor cells at the expense of the oenocytes. In addition, the absence of spalt causes defects in the normal migration of the pentascolopodial organ. The dual function of spalt in the development of this organ, recruitment of precursors and migration, is reminiscent of its role in tracheal formation and of the role of a spalt homologue, sem-4, in the Caenorhabditis elegans nervous system.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  M. Barembaum and M. Bronner-Fraser Spalt4 mediates invagination and otic placode gene expression in cranial ectoderm Development, November 1, 2007; 134(21): 3805 - 3814. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Yamashita, A. Sato, M. Asashima, P.-C. Wang, and R. Nishinakamura Mouse homolog of SALL1, a causative gene for Townes-Brocks syndrome, binds to A/T-rich sequences in pericentric heterochromatin via its C-terminal zinc finger domains. Genes Cells, February 1, 2007; 12(2): 171 - 182. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Parrish, T. Ott, C. Lance-Jones, G. Schuetz, A. Schwaeger-Nickolenko, and A. P. Monaghan Loss of the Sall3 Gene Leads to Palate Deficiency, Abnormalities in Cranial Nerves, and Perinatal Lethality Mol. Cell. Biol., August 15, 2004; 24(16): 7102 - 7112. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. T. Harbison, A. H. Yamamoto, J. J. Fanara, K. K. Norga, and T. F. C. Mackay Quantitative Trait Loci Affecting Starvation Resistance in Drosophila melanogaster Genetics, April 1, 2004; 166(4): 1807 - 1823. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. J. Sepp and V. J. Auld Reciprocal Interactions between Neurons and Glia Are Required for Drosophila Peripheral Nervous System Development J. Neurosci., September 10, 2003; 23(23): 8221 - 8230. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. D. S. Dong, S. V. Todi, D. F. Eberl, and G. Boekhoff-Falk Drosophila spalt/spalt-related mutants exhibit Townes-Brocks' syndrome phenotypes PNAS, September 2, 2003; 100(18): 10293 - 10298. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. S. Toker, Y. Teng, H. B. Ferreira, S. W. Emmons, and M. Chalfie The Caenorhabditis elegans spalt-like gene sem-4 restricts touch cell fate by repressing the selector Hox gene egl-5 and the effector gene mec-3 Development, August 15, 2003; 130(16): 3831 - 3840. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Inbal, D. Levanon, and A. Salzberg Multiple roles for u-turn/ventral veinless in the development of Drosophila PNS Development, June 1, 2003; 130(11): 2467 - 2478. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Cantera, K. Luer, T. E. Rusten, R. Barrio, F. C. Kafatos, and G. M. Technau Mutations in spalt cause a severe but reversible neurodegenerative phenotype in the embryonic central nervous system of Drosophila melanogaster Development, March 14, 2003; 129(24): 5577 - 5586. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Brodu, P. R. Elstob, and A. P. Gould abdominal A specifies one cell type in Drosophila by regulating one principal target gene Development, March 8, 2003; 129(12): 2957 - 2963. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. E. Rusten, R. Cantera, F. C. Kafatos, and R. Barrio The role of TGF{beta} signaling in the formation of the dorsal nervous system is conserved between Drosophila and chordates Development, August 1, 2002; 129(15): 3575 - 3584. [Abstract] [Full Text] [PDF]
|
|
