spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wittwer, F.
Right arrow Articles by Hafen, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wittwer, F.
Right arrow Articles by Hafen, E.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Development, Vol 128, Issue 5 791-800, Copyright © 2001 by Company of Biologists

JOURNAL ARTICLES

Lilliputian: an AF4/FMR2-related protein that controls cell identity and cell growth

F Wittwer, A van der Straten, K Keleman, BJ Dickson and E Hafen
Zoologisches Institut, Universitat Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.

Members of the AF4/FMR2 family of nuclear proteins are involved in human diseases such as acute lymphoblastic leukemia and mental retardation. Here we report the identification and characterization of the Drosophila lilliputian (lilli) gene, which encodes a nuclear protein related to mammalian AF4 and FMR2. Mutations in lilli suppress excessive neuronal differentiation in response to a constitutively active form of Raf in the eye. In the wild type, Lilli has a partially redundant function in the Ras/MAPK pathway in differentiation but it is essential for normal growth. Loss of Lilli function causes an autonomous reduction in cell size and partially suppresses the increased growth associated with loss of PTEN function. These results suggest that Lilli acts in parallel with the Ras/MAPK and the PI3K/PKB pathways in the control of cell identity and cellular growth.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 GeneticsHome page
N. A. Shalaby, A. L. Parks, E. J. Morreale, M. C. Osswalt, K. M. Pfau, E. L. Pierce, and M. A. T. Muskavitch
A Screen for Modifiers of Notch Signaling Uncovers Amun, a Protein With a Critical Role in Sensory Organ Development
Genetics, August 1, 2009; 182(4): 1061 - 1076.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
A. Khokhar, N. Chen, J.-P. Yuan, Y. Li, G. N. Landis, G. Beaulieu, H. Kaur, and J. Tower
Conditional Switches for Extracellular Matrix Patterning in Drosophila melanogaster
Genetics, March 1, 2008; 178(3): 1283 - 1293.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
F. Bejarano, C. M. Luque, H. Herranz, G. Sorrosal, N. Rafel, T. T. Pham, and M. Milan
A Gain-of-Function Suppressor Screen for Genes Involved in Dorsal-Ventral Boundary Formation in the Drosophila Wing
Genetics, January 1, 2008; 178(1): 307 - 323.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
K. L. Pepple, A. E. Anderson, B. J. Frankfort, and G. Mardon
A Genetic Screen in Drosophila for Genes Interacting With senseless During Neuronal Development Identifies the Importin moleskin
Genetics, January 1, 2007; 175(1): 125 - 141.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
T. Mukherjee, U. Schafer, and M. P. Zeidler
Identification of Drosophila Genes Modulating Janus Kinase/Signal Transducer and Activator of Transcription Signal Transduction
Genetics, March 1, 2006; 172(3): 1683 - 1697.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
J. Anderson, R. Bhandari, and J. P. Kumar
A Genetic Screen Identifies Putative Targets and Binding Partners of CREB-Binding Protein in the Developing Drosophila Eye
Genetics, December 1, 2005; 171(4): 1655 - 1672.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
S. Luschnig, B. Moussian, J. Krauss, I. Desjeux, J. Perkovic, and C. Nusslein-Volhard
An F1 Genetic Screen for Maternal-Effect Mutations Affecting Embryonic Pattern Formation in Drosophila melanogaster
Genetics, May 1, 2004; 167(1): 325 - 342.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
J. W. P. Yam, D.-Y. Jin, C. W. So, and L. C. Chan
Identification and characterization of EBP, a novel EEN binding protein that inhibits Ras signaling and is recruited into the nucleus by the MLL-EEN fusion protein
Blood, February 15, 2004; 103(4): 1445 - 1453.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
S. Szuplewski, B. Kottler, and R. Terracol
The Drosophila bZIP transcription factor Vrille is involved in hair and cell growth
Development, August 15, 2003; 130(16): 3651 - 3662.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
J. Li and W. X. Li
Drosophila Gain-of-Function Mutant RTK Torso Triggers Ectopic Dpp and STAT Signaling
Genetics, May 1, 2003; 164(1): 247 - 258.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. M. Isaacs, P. L. Oliver, E. L. Jones, A. Jeans, A. Potter, B. H. Hovik, P. M. Nolan, L. Vizor, P. Glenister, A. K. Simon, et al.
A Mutation in Af4 Is Predicted to Cause Cerebellar Ataxia and Cataracts in the Robotic Mouse
J. Neurosci., March 1, 2003; 23(5): 1631 - 1637.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2001