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Development, Vol 128, Issue 5 801-813, Copyright © 2001 by Company of Biologists

JOURNAL ARTICLES

Transcriptional regulation of cytoskeletal functions and segmentation by a novel maternal pair-rule gene, lilliputian

AH Tang, TP Neufeld, GM Rubin and HA Muller
Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California-Berkeley, Berkeley, California 94720-3200, USA. amy_tang@uclink4.berkeley.edu

Transcriptional control during early Drosophila development is governed by maternal and zygotic factors. We have identified a novel maternal transcriptional regulator gene, lilliputian (lilli), which contains an HMG1 (AT-hook) motif and a domain with similarity to the human fragile X mental retardation FMR2 protein and the AF4 proto-oncoprotein. Embryos lacking maternal lilli expression show specific defects in the establishment of a functional cytoskeleton during cellularization, and exhibit a pair-rule segmentation phenotype. These mutant phenotypes correlate with markedly reduced expression of the early zygotic genes serendipity alpha, fushi tarazu and huckebein, which are essential for cellularization and embryonic patterning. In addition, loss of lilli in adult photoreceptor and bristle cells results in a significant decrease in cell size. Our results indicate that lilli represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis.


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© The Company of Biologists Ltd 2001