|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 128, Issue 7 1033-1043, Copyright © 2001 by Company of Biologists
JOURNAL ARTICLES |
L Sanchez, N Gorfinkiel and I Guerrero
Centro de Investigaciones Biologicas, C.S.I.C., Velazquez 144, Madrid, Spain.
In both sexes, the Drosophila genital disc contains the female and male genital primordia. The sex determination gene doublesex controls which of these primordia will develop and which will be repressed. In females, the presence of Doublesex(F) product results in the development of the female genital primordium and repression of the male primordium. In males, the presence of Doublesex(M) product results in the development and repression of the male and female genital primordia, respectively. This report shows that Doublesex(F) prevents the induction of decapentaplegic by Hedgehog in the repressed male primordium of female genital discs, whereas Doublesex(M) blocks the Wingless pathway in the repressed female primordium of male genital discs. It is also shown that Doublesex(F) is continuously required during female larval development to prevent activation of decapentaplegic in the repressed male primordium, and during pupation for female genital cytodifferentiation. In males, however, it seems that Doublesex(M) is not continuously required during larval development for blocking the Wingless signaling pathway in the female genital primordium. Furthermore, Doublesex(M) does not appear to be needed during pupation for male genital cytodifferentiation. Using dachshund as a gene target for Decapentaplegic and Wingless signals, it was also found that Doublesex(M) and Doublesex(F) both positively and negatively control the response to these signals in male and female genitalia, respectively. A model is presented for the dimorphic sexual development of the genital primordium in which both Doublesex(M) and Doublesex(F) products play positive and negative roles.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  K. Wu, S. Katiyar, A. Witkiewicz, A. Li, P. McCue, L.-N. Song, L. Tian, M. Jin, and R. G. Pestell The Cell Fate Determination Factor Dachshund Inhibits Androgen Receptor Signaling and Prostate Cancer Cellular Growth Cancer Res., April 15, 2009; 69(8): 3347 - 3355. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Yang, W. Zhang, J. R. Bayrer, and M. A. Weiss Doublesex and the Regulation of Sexual Dimorphism in Drosophila melanogaster: STRUCTURE, FUNCTION, AND MUTAGENESIS OF A FEMALE-SPECIFIC DOMAIN J. Biol. Chem., March 14, 2008; 283(11): 7280 - 7292. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Kamping, V. Katju, L. W. Beukeboom, and J. H. Werren Inheritance of Gynandromorphism in the Parasitic Wasp Nasonia vitripennis Genetics, March 1, 2007; 175(3): 1321 - 1333. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Foronda, B. Estrada, L. de Navas, and E. Sanchez-Herrero Requirement of abdominal-A and Abdominal-B in the developing genitalia of Drosophila breaks the posterior downregulation rule Development, January 1, 2006; 133(1): 117 - 127. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Silver and I. Rebay Signaling circuitries in development: insights from the retinal determination gene network Development, January 1, 2005; 132(1): 3 - 13. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Gorfinkiel, L. Sanchez, and I. Guerrero Development of the Drosophila genital disc requires interactions between its segmental primordia Development, March 2, 2003; 130(2): 295 - 305. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Kopp, R. M. Graze, S. Xu, S. B. Carroll, and S. V. Nuzhdin Quantitative Trait Loci Responsible for Variation in Sexually Dimorphic Traits in Drosophila melanogaster Genetics, February 1, 2003; 163(2): 771 - 787. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Dauwalder, S. Tsujimoto, J. Moss, and W. Mattox The Drosophila takeout gene is regulated by the somatic sex-determination pathway and affects male courtship behavior Genes & Dev., November 15, 2002; 16(22): 2879 - 2892. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Lints and S. W. Emmons Regulation of sex-specific differentiation and mating behavior in C. elegans by a new member of the DM domain transcription factor family Genes & Dev., September 15, 2002; 16(18): 2390 - 2402. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Haraguchi, R. Mo, C.-c. Hui, J. Motoyama, S. Makino, T. Shiroishi, W. Gaffield, and G. Yamada Unique functions of Sonic hedgehog signaling during external genitalia development Development, November 1, 2001; 128(21): 4241 - 4250. [Abstract] [Full Text] [PDF]
|
|
