spacer gif spacer gif spacer gif spacer gif ARCHIVE ANNOUNCEMENT! spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kerber, B.
Right arrow Articles by Cohen, S. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kerber, B.
Right arrow Articles by Cohen, S. M.

Development, Vol 128, Issue 8 1231-1238, Copyright © 2001 by Company of Biologists

JOURNAL ARTICLES

The AP-2 transcription factor is required for joint formation and cell survival in Drosophila leg development

B Kerber, I Monge, M Mueller, PJ Mitchell and SM Cohen
European Molecular Biology Laboratory, Meyerhofstr.1, 69117 Heidelberg. scohen@embl-heidelberg.de

Flies mutant for the Drosophila homologue of the mammalian transcription factor AP-2 show a severe reduction in leg length and fail to develop joint structures. Presumptive joint cells express dAP-2 in response to Notch signaling. dAP-2 is required for joint cell differentiation and can induce formation of supernumerary joints when misexpressed. Although dAP-2 is expressed only in presumptive joint cells, its activity is required to support cell survival in the entire leg segment. Taken together, our data indicate that dAP-2 is an important mediator of Notch activity in leg development.


This article has been cited by other articles:


Home page
 J. Cell Biol.Home page
X. Wang, H. A. Pasolli, T. Williams, and E. Fuchs
AP-2 factors act in concert with Notch to orchestrate terminal differentiation in skin epidermis
J. Cell Biol., October 6, 2008; 183(1): 37 - 48.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
W. Feng, J. Huang, J. Zhang, and T. Williams
Identification and Analysis of a Conserved Tcfap2a Intronic Enhancer Element Required for Expression in Facial and Limb Bud Mesenchyme
Mol. Cell. Biol., January 1, 2008; 28(1): 315 - 325.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
R. D. Knight, S. Nair, S. S. Nelson, A. Afshar, Y. Javidan, R. Geisler, G.-J. Rauch, and T. F. Schilling
lockjaw encodes a zebrafish tfap2a required for early neural crest development
Development, December 1, 2003; 130(23): 5755 - 5768.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
H. J. Auman, T. Nottoli, O. Lakiza, Q. Winger, S. Donaldson, and T. Williams
Transcription factor AP-2{gamma} is essential in the extra-embryonic lineages for early postimplantation development
Development, January 6, 2002; 129(11): 2733 - 2747.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
G. R. Buckles, C. Rauskolb, J. L. Villano, and F. N. Katz
four-jointed interacts with dachs, abelson and enabled and feeds back onto the Notch pathway to affect growth and segmentation in the Drosophila leg
Development, September 15, 2001; 128(18): 3533 - 3542.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
P. Pfisterer, J. Ehlermann, M. Hegen, and H. Schorle
A Subtractive Gene Expression Screen Suggests a Role of Transcription Factor AP-2alpha in Control of Proliferation and Differentiation
J. Biol. Chem., February 15, 2002; 277(8): 6637 - 6644.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2001