spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Brault, V.
Right arrow Articles by Kemler, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Brault, V.
Right arrow Articles by Kemler, R.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Development, Vol 128, Issue 8 1253-1264, Copyright © 2001 by Company of Biologists

JOURNAL ARTICLES

Inactivation of the (&bgr;)-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development

V Brault, R Moore, S Kutsch, M Ishibashi, DH Rowitch, AP McMahon, L Sommer, O Boussadia and R Kemler
Department of Molecular Embryology, Max-Planck Institute of Immunobiology, Stuebeweg 51, D-79108 Freiburg, Germany. kemler@immunbio.mpg.de

('bgr;)-Catenin is a central component of both the cadherin-catenin cell adhesion complex and the Wnt signaling pathway. We have investigated the role of (&bgr;)-catenin during brain morphogenesis, by specifically inactivating the (&bgr;)-catenin gene in the region of Wnt1 expression. To achieve this, mice with a conditional ('floxed') allele of (&bgr;)-catenin with required exons flanked by loxP recombination sequences were intercrossed with transgenic mice that expressed Cre recombinase under control of Wnt1 regulatory sequences. (&bgr;)-catenin gene deletion resulted in dramatic brain malformation and failure of craniofacial development. Absence of part of the midbrain and all of the cerebellum is reminiscent of the conventional Wnt1 knockout (Wnt1(-)(/)(-)), suggesting that Wnt1 acts through (&bgr;)-catenin in controlling midbrain-hindbrain development. The craniofacial phenotype, not observed in embryos that lack Wnt1, indicates a role for (&bgr;)-catenin in the fate of neural crest cells. Analysis of neural tube explants shows that (&bgr;)-catenin is efficiently deleted in migrating neural crest cell precursors. This, together with an increased apoptosis in cells migrating to the cranial ganglia and in areas of prechondrogenic condensations, suggests that removal of (&bgr;)-catenin affects neural crest cell survival and/or differentiation. Our results demonstrate the pivotal role of (&bgr;)-catenin in morphogenetic processes during brain and craniofacial development.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Genes Dev.Home page
S. P.J. Fancy, S. E. Baranzini, C. Zhao, D.-I. Yuk, K.-A. Irvine, S. Kaing, N. Sanai, R. J.M. Franklin, and D. H. Rowitch
Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS
Genes & Dev., July 1, 2009; 23(13): 1571 - 1585.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. Tang, Y. Miyamoto, and E. J. Huang
Multiple roles of {beta}-catenin in controlling the neurogenic niche for midbrain dopamine neurons
Development, June 15, 2009; 136(12): 2027 - 2038.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
X.-P. Wang, D. J. O'Connell, J. J. Lund, I. Saadi, M. Kuraguchi, A. Turbe-Doan, R. Cavallesco, H. Kim, P. J. Park, H. Harada, et al.
Apc inhibition of Wnt signaling regulates supernumerary tooth formation during embryogenesis and throughout adulthood
Development, June 1, 2009; 136(11): 1939 - 1949.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
J. A. Hernandez Gifford, M. E. Hunzicker-Dunn, and J. H. Nilson
Conditional Deletion of Beta-Catenin Mediated by Amhr2cre in Mice Causes Female Infertility
Biol Reprod, June 1, 2009; 80(6): 1282 - 1292.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
D. A. Hutcheson, J. Zhao, A. Merrell, M. Haldar, and G. Kardon
Embryonic and fetal limb myogenic cells are derived from developmentally distinct progenitors and have different requirements for {beta}-catenin
Genes & Dev., April 15, 2009; 23(8): 997 - 1013.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
I. V. Chia, M. J. Kim, K. Itoh, S. Y. Sokol, and F. Costantini
Both the RGS Domain and the Six C-Terminal Amino Acids of Mouse Axin Are Required for Normal Embryogenesis
Genetics, April 1, 2009; 181(4): 1359 - 1368.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
C.-F. Liu, N. Bingham, K. Parker, and H. H.-C. Yao
Sex-specific roles of {beta}-catenin in mouse gonadal development
Hum. Mol. Genet., February 1, 2009; 18(3): 405 - 417.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
Y.-T. Chen, M. M. Hims, R. S. Shetty, J. Mull, L. Liu, M. Leyne, and S. A. Slaugenhaupt
Loss of Mouse Ikbkap, a Subunit of Elongator, Leads to Transcriptional Deficits and Embryonic Lethality That Can Be Rescued by Human IKBKAP
Mol. Cell. Biol., February 1, 2009; 29(3): 736 - 744.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Xu, A. Sharma, D. L. Wiest, and J. M. Sen
Pre-TCR-Induced {beta}-Catenin Facilitates Traversal through {beta}-Selection
J. Immunol., January 15, 2009; 182(2): 751 - 758.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
P. Dietrich, R. Shanmugasundaram, S. E, and I. Dragatsis
Congenital hydrocephalus associated with abnormal subcommissural organ in mice lacking huntingtin in Wnt1 cell lineages
Hum. Mol. Genet., January 1, 2009; 18(1): 142 - 150.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
S. Fuhrmann, A. N. Riesenberg, A. M. Mathiesen, E. C. Brown, M. L. Vetter, and N. L. Brown
Characterization of a Transient TCF/LEF-Responsive Progenitor Population in the Embryonic Mouse Retina
Invest. Ophthalmol. Vis. Sci., January 1, 2009; 50(1): 432 - 440.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
C. McCusker, H. Cousin, R. Neuner, and D. Alfandari
Extracellular Cleavage of Cadherin-11 by ADAM Metalloproteases Is Essential for Xenopus Cranial Neural Crest Cell Migration
Mol. Biol. Cell, January 1, 2009; 20(1): 78 - 89.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
A. Gurung, F. Uddin, R. P. Hill, P. C. Ferguson, and B. A. Alman
{beta}-Catenin Is a Mediator of the Response of Fibroblasts to Irradiation
Am. J. Pathol., January 1, 2009; 174(1): 248 - 255.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
H. Koso, A. Iida, Y. Tabata, Y. Baba, S. Satoh, M. M. Taketo, and S. Watanabe
CD138/Syndecan-1 and SSEA-1 Mark Distinct Populations of Developing Ciliary Epithelium That Are Regulated Differentially by Wnt Signal
Stem Cells, December 1, 2008; 26(12): 3162 - 3171.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
J. M. Stenman, J. Rajagopal, T. J. Carroll, M. Ishibashi, J. McMahon, and A. P. McMahon
Canonical Wnt Signaling Regulates Organ-Specific Assembly and Differentiation of CNS Vasculature
Science, November 21, 2008; 322(5905): 1247 - 1250.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
W. Yu, K. McDonnell, M. M. Taketo, and C. B. Bai
Wnt signaling determines ventral spinal cord cell fates in a time-dependent manner
Development, November 15, 2008; 135(22): 3687 - 3696.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Y. S. Kalani, S. H. Cheshier, B. J. Cord, S. R. Bababeygy, H. Vogel, I. L. Weissman, T. D. Palmer, and R. Nusse
Wnt-mediated self-renewal of neural stem/progenitor cells
PNAS, November 4, 2008; 105(44): 16970 - 16975.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
S. Liebner, M. Corada, T. Bangsow, J. Babbage, A. Taddei, C. J. Czupalla, M. Reis, A. Felici, H. Wolburg, M. Fruttiger, et al.
Wnt/{beta}-catenin signaling controls development of the blood-brain barrier
J. Cell Biol., November 3, 2008; 183(3): 409 - 417.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Q. Yu, W. J. Quinn III, T. Salay, J. E. Crowley, M. P. Cancro, and J. M. Sen
Role of {beta}-Catenin in B Cell Development and Function
J. Immunol., September 15, 2008; 181(6): 3777 - 3783.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
T. Grigoryan, P. Wend, A. Klaus, and W. Birchmeier
Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of {beta}-catenin in mice
Genes & Dev., September 1, 2008; 22(17): 2308 - 2341.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
C. Lin, Y. Yin, F. Long, and L. Ma
Tissue-specific requirements of {beta}-catenin in external genitalia development
Development, August 15, 2008; 135(16): 2815 - 2825.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
A. C. Kim, A. L. Reuter, M. Zubair, T. Else, K. Serecky, N. C. Bingham, G. G. Lavery, K. L. Parker, and G. D. Hammer
Targeted disruption of {beta}-catenin in Sf1-expressing cells impairs development and maintenance of the adrenal cortex
Development, August 1, 2008; 135(15): 2593 - 2602.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
J. Ohtola, J. Myers, B. Akhtar-Zaidi, D. Zuzindlak, P. Sandesara, K. Yeh, S. Mackem, and R. Atit
{beta}-Catenin has sequential roles in the survival and specification of ventral dermis
Development, July 1, 2008; 135(13): 2321 - 2329.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
C. S. Jayasena, T. Ohyama, N. Segil, and A. K. Groves
Notch signaling augments the canonical Wnt pathway to specify the size of the otic placode
Development, July 1, 2008; 135(13): 2251 - 2261.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. Badde and D. Schulte
A Role for Receptor Protein Tyrosine Phosphatase {lambda} in Midbrain Development
J. Neurosci., June 11, 2008; 28(24): 6152 - 6164.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
C. Sustmann, H. Flach, H. Ebert, Q. Eastman, and R. Grosschedl
Cell-Type-Specific Function of BCL9 Involves a Transcriptional Activation Domain That Synergizes with {beta}-Catenin
Mol. Cell. Biol., May 15, 2008; 28(10): 3526 - 3537.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
H. Chang, F. Gao, F. Guillou, M. M. Taketo, V. Huff, and R. R. Behringer
Wt1 negatively regulates {beta}-catenin signaling during testis development
Development, May 15, 2008; 135(10): 1875 - 1885.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Pathol.Home page
H K Datta, W F Ng, J A Walker, S P Tuck, and S S Varanasi
The cell biology of bone metabolism
J. Clin. Pathol., May 1, 2008; 61(5): 577 - 587.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
M. Chen, M. Zhu, H. Awad, T.-F. Li, T.-J. Sheu, B. F. Boyce, D. Chen, and R. J. O'Keefe
Inhibition of {beta}-catenin signaling causes defects in postnatal cartilage development
J. Cell Sci., May 1, 2008; 121(9): 1455 - 1465.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
X. Sun, R. Zhang, X. Lin, and X. Xu
Wnt3a Regulates the Development of Cardiac Neural Crest Cells by Modulating Expression of Cysteine-Rich Intestinal Protein 2 in Rhombomere 6
Circ. Res., April 11, 2008; 102(7): 831 - 839.
[Abstract] [Full Text] [PDF]

Home page
 JDRHome page
M. Nagayama, M. Iwamoto, A. Hargett, N. Kamiya, Y. Tamamura, B. Young, T. Morrison, H. Takeuchi, M. Pacifici, M. Enomoto-Iwamoto, et al.
Wnt/{beta}-catenin Signaling Regulates Cranial Base Development and Growth
Journal of Dental Research, March 1, 2008; 87(3): 244 - 249.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
W. C. Dunty Jr, K. K. Biris, R. B. Chalamalasetty, M. M. Taketo, M. Lewandoski, and T. P. Yamaguchi
Wnt3a/ -catenin signaling controls posterior body development by coordinating mesoderm formation and segmentation
Development, January 1, 2008; 135(1): 85 - 94.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
H. Yi, R. E. I. Nakamura, O. Mohamed, D. Dufort, and A. S. Hackam
Characterization of Wnt Signaling during Photoreceptor Degeneration
Invest. Ophthalmol. Vis. Sci., December 1, 2007; 48(12): 5733 - 5741.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Zamora, J. Manner, and P. Ruiz-Lozano
Epicardium-derived progenitor cells require {beta}-catenin for coronary artery formation
PNAS, November 13, 2007; 104(46): 18109 - 18114.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
K. Aoki and M. M. Taketo
Adenomatous polyposis coli (APC): a multi-functional tumor suppressor gene
J. Cell Sci., October 1, 2007; 120(19): 3327 - 3335.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
T. Okuda, L. M. Y. Yu, L. A. Cingolani, R. Kemler, and Y. Goda
beta-Catenin regulates excitatory postsynaptic strength at hippocampal synapses
PNAS, August 14, 2007; 104(33): 13479 - 13484.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
Y. Wang, M. Giel-Moloney, G. Rindi, and A. B. Leiter
Enteroendocrine precursors differentiate independently of Wnt and form serotonin expressing adenomas in response to active beta-catenin
PNAS, July 3, 2007; 104(27): 11328 - 11333.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
J.-S. Park, M. T. Valerius, and A. P. McMahon
Wnt/{beta}-catenin signaling regulates nephron induction during mouse kidney development
Development, July 1, 2007; 134(13): 2533 - 2539.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
C. Kwon, J. Arnold, E. C. Hsiao, M. M. Taketo, B. R. Conklin, and D. Srivastava
Canonical Wnt signaling is a positive regulator of mammalian cardiac progenitors
PNAS, June 26, 2007; 104(26): 10894 - 10899.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
L. Lin, L. Cui, W. Zhou, D. Dufort, X. Zhang, C.-L. Cai, L. Bu, L. Yang, J. Martin, R. Kemler, et al.
beta-Catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis
PNAS, May 29, 2007; 104(22): 9313 - 9318.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
D. Ai, X. Fu, J. Wang, M.-F. Lu, L. Chen, A. Baldini, W. H. Klein, and J. F. Martin
Canonical Wnt signaling functions in second heart field to promote right ventricular growth
PNAS, May 29, 2007; 104(22): 9319 - 9324.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
N. Song, K. R. Schwab, L. T. Patterson, T. Yamaguchi, X. Lin, S. S. Potter, and R. A. Lang
pygopus 2 has a crucial, Wnt pathway-independent function in lens induction
Development, May 15, 2007; 134(10): 1873 - 1885.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
C. Kimura-Yoshida, E. Tian, H. Nakano, S. Amazaki, K. Shimokawa, J. Rossant, S. Aizawa, and I. Matsuo
Crucial roles of Foxa2 in mouse anterior-posterior axis polarization via regulation of anterior visceral endoderm-specific genes
PNAS, April 3, 2007; 104(14): 5919 - 5924.
[Abstract] [Full Text] [PDF]

Home page
 JDRHome page
Y. Lu, Y. Xie, S. Zhang, V. Dusevich, L.F. Bonewald, and J.Q. Feng
DMP1-targeted Cre Expression in Odontoblasts and Osteocytes
Journal of Dental Research, April 1, 2007; 86(4): 320 - 325.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. I. Reinhold and M. C. Naski
Direct Interactions of Runx2 and Canonical Wnt Signaling Induce FGF18
J. Biol. Chem., February 9, 2007; 282(6): 3653 - 3663.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Chen, H. C. Whetstone, A. Youn, P. Nadesan, E. C. Y. Chow, A. C. Lin, and B. A. Alman
beta-Catenin Signaling Pathway Is Crucial for Bone Morphogenetic Protein 2 to Induce New Bone Formation
J. Biol. Chem., January 5, 2007; 282(1): 526 - 533.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. Zhou, J. Qu, X. P. Yi, K. Graber, L. Huber, X. Wang, A. M. Gerdes, and F. Li
Upregulation of {gamma}-catenin compensates for the loss of beta-catenin in adult cardiomyocytes
Am J Physiol Heart Circ Physiol, January 1, 2007; 292(1): H270 - H276.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
C. E. Wong, C. Paratore, M. T. Dours-Zimmermann, A. Rochat, T. Pietri, U. Suter, D. R. Zimmermann, S. Dufour, J. P. Thiery, D. Meijer, et al.
Neural crest-derived cells with stem cell features can be traced back to multiple lineages in the adult skin
J. Cell Biol., December 18, 2006; 175(6): 1005 - 1015.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
F. Dong, X. Sun, W. Liu, D. Ai, E. Klysik, M.-F. Lu, J. Hadley, L. Antoni, L. Chen, A. Baldini, et al.
Pitx2 promotes development of splanchnic mesoderm-derived branchiomeric muscle
Development, December 15, 2006; 133(24): 4891 - 4899.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
G. J. Woodhead, C. A. Mutch, E. C. Olson, and A. Chenn
Cell-Autonomous beta-Catenin Signaling Regulates Cortical Precursor Proliferation
J. Neurosci., November 29, 2006; 26(48): 12620 - 12630.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
J. E. Lee, S.-F. Wu, L. M. Goering, and R. I. Dorsky
Canonical Wnt signaling through Lef1 is required for hypothalamic neurogenesis
Development, November 15, 2006; 133(22): 4451 - 4461.
[Abstract] [Full Text] [PDF]

Home page
 JDRHome page
J.J. Mao, W.V. Giannobile, J.A. Helms, S.J. Hollister, P.H. Krebsbach, M.T. Longaker, and S. Shi
Craniofacial Tissue Engineering by Stem Cells
Journal of Dental Research, November 1, 2006; 85(11): 966 - 979.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
T. Brade, J. Manner, and M. Kuhl
The role of Wnt signalling in cardiac development and tissue remodelling in the mature heart
Cardiovasc Res, November 1, 2006; 72(2): 198 - 209.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
U. Borello, B. Berarducci, P. Murphy, L. Bajard, V. Buffa, S. Piccolo, M. Buckingham, and G. Cossu
The Wnt/{beta}-catenin pathway regulates Gli-mediated Myf5 expression during somitogenesis
Development, September 15, 2006; 133(18): 3723 - 3732.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
C. Wiese, A. Rolletschek, G. Kania, A. Navarrete-Santos, S. V. Anisimov, B. Steinfarz, K. V. Tarasov, S. A. Brugh, I. Zahanich, C. Ruschenschmidt, et al.
Signals from Embryonic Fibroblasts Induce Adult Intestinal Epithelial Cells to Form Nestin-Positive Cells with Proliferation and Multilineage Differentiation Capacity In Vitro
Stem Cells, September 1, 2006; 24(9): 2085 - 2097.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
S. J. Rodda and A. P. McMahon
Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors
Development, August 15, 2006; 133(16): 3231 - 3244.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T.-F. Li, D. Chen, Q. Wu, M. Chen, T.-j. Sheu, E. M. Schwarz, H. Drissi, M. Zuscik, and R. J. O'Keefe
Transforming Growth Factor-beta Stimulates Cyclin D1 Expression through Activation of beta-Catenin Signaling in Chondrocytes
J. Biol. Chem., July 28, 2006; 281(30): 21296 - 21304.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
X. Chen, S. P. Shevtsov, E. Hsich, L. Cui, S. Haq, M. Aronovitz, R. Kerkela, J. D. Molkentin, R. Liao, R. N. Salomon, et al.
The {beta}-Catenin/T-Cell Factor/Lymphocyte Enhancer Factor Signaling Pathway Is Required for Normal and Stress-Induced Cardiac Hypertrophy
Mol. Cell. Biol., June 15, 2006; 26(12): 4462 - 4473.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
S. S. Cheon, Q. Wei, A. Gurung, A. Youn, T. Bright, R. Poon, H. Whetstone, A. Guha, and B. A. Alman
Beta-catenin regulates wound size and mediates the effect of TGF-beta in cutaneous healing
FASEB J, April 1, 2006; 20(6): 692 - 701.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
T. Ohyama, O. A. Mohamed, M. M. Taketo, D. Dufort, and A. K. Groves
Wnt signals mediate a fate decision between otic placode and epidermis
Development, March 1, 2006; 133(5): 865 - 875.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
A. L. Evans and P. J. Gage
Expression of the homeobox gene Pitx2 in neural crest is required for optic stalk and ocular anterior segment development
Hum. Mol. Genet., November 15, 2005; 14(22): 3347 - 3359.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
L. C. Murtaugh, A. C. Law, Y. Dor, and D. A. Melton
{beta}-Catenin is essential for pancreatic acinar but not islet development
Development, November 1, 2005; 132(21): 4663 - 4674.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Gaur, C. J. Lengner, H. Hovhannisyan, R. A. Bhat, P. V. N. Bodine, B. S. Komm, A. Javed, A. J. van Wijnen, J. L. Stein, G. S. Stein, et al.
Canonical WNT Signaling Promotes Osteogenesis by Directly Stimulating Runx2 Gene Expression
J. Biol. Chem., September 30, 2005; 280(39): 33132 - 33140.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
K. Grobe, M. Inatani, S. R. Pallerla, J. Castagnola, Y. Yamaguchi, and J. D. Esko
Cerebral hypoplasia and craniofacial defects in mice lacking heparan sulfate Ndst1 gene function
Development, August 15, 2005; 132(16): 3777 - 3786.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. L. Holmen, C. R. Zylstra, A. Mukherjee, R. E. Sigler, M.-C. Faugere, M. L. Bouxsein, L. Deng, T. L. Clemens, and B. O. Williams
Essential Role of {beta}-Catenin in Postnatal Bone Acquisition
J. Biol. Chem., June 3, 2005; 280(22): 21162 - 21168.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
H. Lickert, B. Cox, C. Wehrle, M. M. Taketo, R. Kemler, and J. Rossant
Dissecting Wnt/{beta}-catenin signaling during gastrulation using RNA interference in mouse embryos
Development, June 1, 2005; 132(11): 2599 - 2609.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
H.-M. I. Yu, B. Jerchow, T.-J. Sheu, B. Liu, F. Costantini, J. E. Puzas, W. Birchmeier, and W. Hsu
The role of Axin2 in calvarial morphogenesis and craniosynostosis
Development, April 15, 2005; 132(8): 1995 - 2005.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
H. Wurdak, L. M. Ittner, K. S. Lang, P. Leveen, U. Suter, J. A. Fischer, S. Karlsson, W. Born, and L. Sommer
Inactivation of TGF{beta} signaling in neural crest stem cells leads to multiple defects reminiscent of DiGeorge syndrome
Genes & Dev., March 1, 2005; 19(5): 530 - 535.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
H. Hu, M. J. Hilton, X. Tu, K. Yu, D. M. Ornitz, and F. Long
Sequential roles of Hedgehog and Wnt signaling in osteoblast development
Development, January 1, 2005; 132(1): 49 - 60.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
W. N. de Vries, A. V. Evsikov, B. E. Haac, K. S. Fancher, A. E. Holbrook, R. Kemler, D. Solter, and B. B. Knowles
Maternal {beta}-catenin and E-cadherin in mouse development
Development, September 15, 2004; 131(18): 4435 - 4445.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
S. Liebner, A. Cattelino, R. Gallini, N. Rudini, M. Iurlaro, S. Piccolo, and E. Dejana
{beta}-Catenin is required for endothelial-mesenchymal transformation during heart cushion development in the mouse
J. Cell Biol., August 2, 2004; 166(3): 359 - 367.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Pathol.Home page
M A Dyer
Mouse models of childhood cancer of the nervous system
J. Clin. Pathol., June 1, 2004; 57(6): 561 - 576.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
H. Akiyama, J. P. Lyons, Y. Mori-Akiyama, X. Yang, R. Zhang, Z. Zhang, J. M. Deng, M. M. Taketo, T. Nakamura, R. R. Behringer, et al.
Interactions between Sox9 and {beta}-catenin control chondrocyte differentiation
Genes & Dev., May 1, 2004; 18(9): 1072 - 1087.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
R. W. Stottmann, M. Choi, Y. Mishina, E. N. Meyers, and J. Klingensmith
BMP receptor IA is required in mammalian neural crest cells for development of the cardiac outflow tract and ventricular myocardium
Development, May 1, 2004; 131(9): 2205 - 2218.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
J. L. Lewis, J. Bonner, M. Modrell, J. W. Ragland, R. T. Moon, R. I. Dorsky, and D. W. Raible
Reiterated Wnt signaling during zebrafish neural crest development
Development, March 15, 2004; 131(6): 1299 - 1308.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
H.-Y. Lee, M. Kleber, L. Hari, V. Brault, U. Suter, M. M. Taketo, R. Kemler, and L. Sommer
Instructive Role of Wnt/{beta}-Catenin in Sensory Fate Specification in Neural Crest Stem Cells
Science, February 13, 2004; 303(5660): 1020 - 1023.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
M. Cobas, A. Wilson, B. Ernst, S. J.C. Mancini, H. R. MacDonald, R. Kemler, and F. Radtke
{beta}-Catenin Is Dispensable for Hematopoiesis and Lymphopoiesis
J. Exp. Med., January 20, 2004; 199(2): 221 - 229.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
J. Yang, J. Wu, C. Tan, and P. S. Klein
PP2A:B56{epsilon} is required for Wnt/{beta}-catenin signaling during embryonic development
Development, December 1, 2003; 130(23): 5569 - 5578.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
A. Cattelino, S. Liebner, R. Gallini, A. Zanetti, G. Balconi, A. Corsi, P. Bianco, H. Wolburg, R. Moore, B. Oreda, et al.
The conditional inactivation of the {beta}-catenin gene in endothelial cells causes a defective vascular pattern and increased vascular fragility
J. Cell Biol., September 15, 2003; 162(6): 1111 - 1122.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
A. Chenn and C. A. Walsh
Increased Neuronal Production, Enlarged Forebrains and Cytoarchitectural Distortions in {beta}-Catenin Overexpressing Transgenic Mice
Cereb Cortex, June 1, 2003; 13(6): 599 - 606.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
M. G. Lampugnani, A. Zanetti, M. Corada, T. Takahashi, G. Balconi, F. Breviario, F. Orsenigo, A. Cattelino, R. Kemler, T. O. Daniel, et al.
Contact inhibition of VEGF-induced proliferation requires vascular endothelial cadherin, {beta}-catenin, and the phosphatase DEP-1/CD148
J. Cell Biol., May 26, 2003; 161(4): 793 - 804.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
I. Salazar-Ciudad, J. Jernvall, and S. A. Newman
Mechanisms of pattern formation in development and evolution
Development, May 15, 2003; 130(10): 2027 - 2037.
[Abstract] [Full Text] [PDF]

Home page
 CROBMHome page
Y. Chai, Y. Ito, and J. Han
TGF-{beta} SIGNALING AND ITS FUNCTIONAL SIGNIFICANCE IN REGULATING THE FATE OF CRANIAL NEURAL CREST CELLS
Critical Reviews in Oral Biology & Medicine, March 1, 2003; 14(2): 78 - 88.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
J. R. Barrow, K. R. Thomas, O. Boussadia-Zahui, R. Moore, R. Kemler, M. R. Capecchi, and A. P. McMahon
Ectodermal Wnt3/beta -catenin signaling is required for the establishment and maintenance of the apical ectodermal ridge
Genes & Dev., February 1, 2003; 17(3): 394 - 409.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
L. Hari, V. Brault, M. Kleber, H.-Y. Lee, F. Ille, R. Leimeroth, C. Paratore, U. Suter, R. Kemler, and L. Sommer
Lineage-specific requirements of {beta}-catenin in neural crest development
J. Cell Biol., December 9, 2002; 159(5): 867 - 880.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
B. Wortman, N. Darbinian, B. E. Sawaya, K. Khalili, and S. Amini
Evidence for Regulation of Long Terminal Repeat Transcription by Wnt Transcription Factor TCF-4 in Human Astrocytic Cells
J. Virol., October 2, 2002; 76(21): 11159 - 11165.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
H. R. Widlund, M. A. Horstmann, E. R. Price, J. Cui, S. L. Lessnick, M. Wu, X. He, and D. E. Fisher
{beta}-Catenin-induced melanoma growth requires the downstream target Microphthalmia-associated transcription factor
J. Cell Biol., September 16, 2002; 158(6): 1079 - 1087.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
A. Chenn and C. A. Walsh
Regulation of Cerebral Cortical Size by Control of Cell Cycle Exit in Neural Precursors
Science, July 19, 2002; 297(5580): 365 - 369.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. Gradl, A. Konig, and D. Wedlich
Functional Diversity of Xenopus Lymphoid Enhancer Factor/T-cell Factor Transcription Factors Relies on Combinations of Activating and Repressing Elements
J. Biol. Chem., April 12, 2002; 277(16): 14159 - 14171.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
H. Posthaus, L. Williamson, D. Baumann, R. Kemler, R. Caldelari, M. M. Suter, H. Schwarz, and E. Muller
{beta}-Catenin is not required for proliferation and differentiation of epidermal mouse keratinocytes
J. Cell Sci., January 12, 2002; 115(23): 4587 - 4595.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
D. Hartmann
From Alzheimer's disease to skin tumors: The catenin connection
PNAS, September 11, 2001; 98(19): 10522 - 10523.
[Full Text] [PDF]

Home page
 JCBHome page
X. Xu, W.E.I. Li, G.Y. Huang, R. Meyer, T. Chen, Y. Luo, M.P. Thomas, G.L. Radice, and C.W. Lo
Modulation of mouse neural crest cell motility by N-cadherin and connexin 43 gap junctions
J. Cell Biol., July 9, 2001; 154(1): 217 - 230.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2001