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Development, Vol 128, Issue 8 1457-1466, Copyright © 2001 by Company of Biologists
JOURNAL ARTICLES |
G Udolph, P Rath and W Chia
Developmental Neurobiology Laboratory, Institute of Molecular and Cell Biology, Singapore 117609. mcbwchia@imcb.nus.edu.sg
In the Drosophila central nervous system (CNS) glial cells are known to be generated from glioblasts, which produce exclusively glia or neuroglioblasts that bifurcate to produce both neuronal and glial sublineages. We show that the genesis of a subset of glial cells, the subperineurial glia (SPGs), involves a new mechanism and requires Notch. We demonstrate that the SPGs share direct sibling relationships with neurones and are the products of asymmetric divisions. This mechanism of specifying glial cell fates within the CNS is novel and provides further insight into regulatory interactions leading to glial cell fate determination. Furthermore, we show that Notch signalling positively regulates glial cells missing (gcm) expression in the context of SPG development.
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