|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 128, Issue 8 1467-1479, Copyright © 2001 by Company of Biologists
JOURNAL ARTICLES |
R Kos, MV Reedy, RL Johnson and CA Erickson
Section of Molecular and Cellular Biology, University of California-Davis, Davis, CA 95616, USA. caerickson@ucdavis.edu
The winged-helix or forkhead class of transcription factors has been shown to play important roles in cell specification and lineage segregation. We have cloned the chicken homolog of FoxD3, a member of the winged-helix class of transcription factors, and analyzed its expression. Based on its expression in the dorsal neural tube and in all neural crest lineages except the late-emigrating melanoblasts, we predicted that FoxD3 might be important in the segregation of the neural crest lineage from the neural epithelium, and for repressing melanogenesis in early-migrating neural crest cells. Misexpression of FoxD3 by electroporation in the lateral neural epithelium early in neural crest development produced an expansion of HNK1 immunoreactivity throughout the neural epithelium, although these cells did not undergo an epithelial/mesenchymal transformation. To test whether FoxD3 represses melanogenesis in early migrating neural crest cells, we knocked down expression in cultured neural crest with antisense oligonucleotides and in vivo by treatment with morpholino antisense oligonucleotides. Both experimental approaches resulted in an expansion of the melanoblast lineage, probably at the expense of neuronal and glial lineages. Conversely, persistent expression of FoxD3 in late-migrating neural crest cells using RCAS viruses resulted in the failure of melanoblasts to develop. We suggest that FoxD3 plays two important roles in neural crest development. First, it is involved in the segregation of the neural crest lineage from the neuroepithelium. Second, it represses melanogenesis, thereby allowing other neural crest derivatives to differentiate during the early stages of neural crest patterning.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  B. L. Arduini, K. M. Bosse, and P. D. Henion Genetic ablation of neural crest cell diversification Development, June 15, 2009; 136(12): 1987 - 1994. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Ahlstrom and C. A. Erickson The neural crest epithelial-mesenchymal transition in 4D: a `tail' of multiple non-obligatory cellular mechanisms Development, June 1, 2009; 136(11): 1801 - 1812. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Thomas and C. A. Erickson FOXD3 regulates the lineage switch between neural crest-derived glial cells and pigment cells by repressing MITF through a non-canonical mechanism Development, June 1, 2009; 136(11): 1849 - 1858. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Osorio, M.-A. Teillet, and M. Catala Role of noggin as an upstream signal in the lack of neuronal derivatives found in the avian caudal-most neural crest Development, May 15, 2009; 136(10): 1717 - 1726. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Harris, R. Hall, and C. A. Erickson Directing pathfinding along the dorsolateral path - the role of EDNRB2 and EphB2 in overcoming inhibition Development, December 15, 2008; 135(24): 4113 - 4122. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Eisen and J. C. Smith Controlling morpholino experiments: don't stop making antisense Development, May 15, 2008; 135(10): 1735 - 1743. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Teng, N. A. Mundell, A. Y. Frist, Q. Wang, and P. A. Labosky Requirement for Foxd3 in the maintenance of neural crest progenitors Development, May 1, 2008; 135(9): 1615 - 1624. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Zhao, K. Tanegashima, H. Ro, and I. B. Dawid Lrig3 regulates neural crest formation in Xenopus by modulating Fgf and Wnt signaling pathways Development, April 1, 2008; 135(7): 1283 - 1293. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. J. Kang, D. H. Adams, A. Simen, B. B. Simen, G. Rajkowska, C. A. Stockmeier, J. C. Overholser, H. Y. Meltzer, G. J. Jurjus, L. C. Konick, et al. Gene Expression Profiling in Postmortem Prefrontal Cortex of Major Depressive Disorder J. Neurosci., November 28, 2007; 27(48): 13329 - 13340. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. F. Gilbert, G. Bender, E. Betters, M. Yin, and J. A. Cebra-Thomas The contribution of neural crest cells to the nuchal bone and plastron of the turtle shell Integr. Comp. Biol., September 1, 2007; 47(3): 401 - 408. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Yaklichkin, A. B. Steiner, Q. Lu, and D. S. Kessler FoxD3 and Grg4 Physically Interact to Repress Transcription and Induce Mesoderm in Xenopus J. Biol. Chem., January 26, 2007; 282(4): 2548 - 2557. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. B. Steiner, M. J. Engleka, Q. Lu, E. C. Piwarzyk, S. Yaklichkin, J. L. Lefebvre, J. W. Walters, L. Pineda-Salgado, P. A. Labosky, and D. S. Kessler FoxD3 regulation of Nodal in the Spemann organizer is essential for Xenopus dorsal mesoderm development Development, December 15, 2006; 133(24): 4827 - 4838. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Sakai, T. Suzuki, N. Osumi, and Y. Wakamatsu Cooperative action of Sox9, Snail2 and PKA signaling in early neural crest development Development, April 1, 2006; 133(7): 1323 - 1333. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. E. Whitlock, K. M. Smith, H. Kim, and M. V. Harden A role for foxd3 and sox10 in the differentiation of gonadotropin-releasing hormone (GnRH) cells in the zebrafish Danio rerio Development, December 15, 2005; 132(24): 5491 - 5502. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. A. Taneyhill and M. Bronner-Fraser Dynamic Alterations in Gene Expression after Wnt-mediated Induction of Avian Neural Crest Mol. Biol. Cell, November 1, 2005; 16(11): 5283 - 5293. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. W. Klee, K. J. Shim, M. A. Pickart, S. C. Ekker, and L. B. M. Ellis AMOD: a morpholino oligonucleotide selection tool Nucleic Acids Res., July 1, 2005; 33(suppl_2): W506 - W511. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Burstyn-Cohen, J. Stanleigh, D. Sela-Donenfeld, and C. Kalcheim Canonical Wnt activity regulates trunk neural crest delamination linking BMP/noggin signaling with G1/S transition Development, November 1, 2004; 131(21): 5327 - 5339. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Perez-Alcala, M. A. Nieto, and J. A. Barbas LSox5 regulates RhoB expression in the neural tube and promotes generation of the neural crest Development, September 15, 2004; 131(18): 4455 - 4465. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. V. Chizhikov and K. J. Millen Control of roof plate formation by Lmx1a in the developing spinal cord Development, June 1, 2004; 131(11): 2693 - 2705. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. E. Craven, K.-C. Lim, W. Ye, J. D. Engel, F. de Sauvage, and A. Rosenthal Gata2 specifies serotonergic neurons downstream of sonic hedgehog Development, March 1, 2004; 131(5): 1165 - 1173. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Cheung and J. Briscoe Neural crest development is regulated by the transcription factor Sox9 Development, December 1, 2003; 130(23): 5681 - 5693. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. Knight, S. Nair, S. S. Nelson, A. Afshar, Y. Javidan, R. Geisler, G.-J. Rauch, and T. F. Schilling lockjaw encodes a zebrafish tfap2a required for early neural crest development Development, December 1, 2003; 130(23): 5755 - 5768. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. S. Gammill and M. Bronner-Fraser Genomic analysis of neural crest induction Development, March 14, 2003; 129(24): 5731 - 5741. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. A. Hanna, R. K. Foreman, I. A. Tarasenko, D. S. Kessler, and P. A. Labosky Requirement for Foxd3 in maintaining pluripotent cells of the early mouse embryo Genes & Dev., October 15, 2002; 16(20): 2650 - 2661. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. B. Gould and S. W. M. John Anterior segment dysgenesis and the developmental glaucomas are complex traits Hum. Mol. Genet., May 15, 2002; 11(10): 1185 - 1193. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. G. del Barrio and M. A. Nieto Overexpression of Snail family members highlights their ability to promote chick neural crest formation Development, January 4, 2002; 129(7): 1583 - 1593. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Dottori, M. K. Gross, P. Labosky, and M. Goulding The winged-helix transcription factor Foxd3 suppresses interneuron differentiation and promotes neural crest cell fate Development, November 1, 2001; 128(21): 4127 - 4138. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Sasai, K. Mizuseki, and Y. Sasai Requirement of FoxD3-class signaling for neural crest determination in Xenopus Development, July 1, 2001; 128(13): 2525 - 2536. [Abstract] [Full Text] [PDF]
|
|
