|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 128, Issue 9 1547-1558, Copyright © 2001 by Company of Biologists
JOURNAL ARTICLES |
AV Tkatchenko, RP Visconti, L Shang, T Papenbrock, ND Pruett, T Ito, M Ogawa and A Awgulewitsch
Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.
Studying the roles of Hox genes in normal and pathological development of skin and hair requires identification of downstream target genes in genetically defined animal models. We show that transgenic mice overexpressing Hoxc13 in differentiating keratinocytes of hair follicles develop alopecia, accompanied by a progressive pathological skin condition that resembles ichthyosis. Large-scale analysis of differential gene expression in postnatal skin of these mice identified 16 previously unknown and 13 known genes as presumptive Hoxc13 targets. The majority of these targets are downregulated and belong to a subgroup of genes that encode hair-specific keratin-associated proteins (KAPs). Genomic mapping using a mouse hamster radiation hybrid panel showed these genes to reside in a novel KAP gene cluster on mouse chromosome 16 in a region of conserved linkage with human chromosome 21q22.11. Furthermore, data obtained by Hoxc13/lacZ reporter gene analysis in mice that overexpress Hoxc13 suggest negative autoregulatory feedback control of Hoxc13 expression levels, thus providing an entry point for elucidating currently unknown mechanisms that are required for regulating quantitative levels of Hox gene expression. Combined, these results provide a framework for understanding molecular mechanisms of Hoxc13 function in hair growth and development.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  M. Kiso, S. Tanaka, R. Saba, S. Matsuda, A. Shimizu, M. Ohyama, H. J. Okano, T. Shiroishi, H. Okano, and Y. Saga The disruption of Sox21-mediated hair shaft cuticle differentiation causes cyclic alopecia in mice PNAS, June 9, 2009; 106(23): 9292 - 9297. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Hwang, T. Mehrani, S. E. Millar, and M. I. Morasso Dlx3 is a crucial regulator of hair follicle differentiation and cycling Development, September 15, 2008; 135(18): 3149 - 3159. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Kurek, G. A. Garinis, J. H. van Doorninck, J. van der Wees, and F. G. Grosveld Transcriptome and phenotypic analysis reveals Gata3-dependent signalling pathways in murine hair follicles Development, January 15, 2007; 134(2): 261 - 272. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. S. Potter, R. L. Peterson, J. L. Barth, N. D. Pruett, D. F. Jacobs, M. J. Kern, W. S. Argraves, J. P. Sundberg, and A. Awgulewitsch Evidence That the Satin Hair Mutant Gene Foxq1 Is among Multiple and Functionally Diverse Regulatory Targets for Hoxc13 during Hair Follicle Differentiation J. Biol. Chem., September 29, 2006; 281(39): 29245 - 29255. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Chen, E. Rubin, H. Zhang, S. Chung, C. C. Jie, E. Garrett, S. Biswal, and S. Sukumar Identification of Transcriptional Targets of HOXA5 J. Biol. Chem., May 13, 2005; 280(19): 19373 - 19380. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. E. Olson, J. Zhang, H. Taylor, D. W. Rose, and M. G. Rosenfeld Barx2 functions through distinct corepressor classes to regulate hair follicle remodeling PNAS, March 8, 2005; 102(10): 3708 - 3713. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. D. Pruett, T. V. Tkatchenko, L. Jave-Suarez, D. F. Jacobs, C. S. Potter, A. V. Tkatchenko, J. Schweizer, and A. Awgulewitsch Krtap16, Characterization of a New Hair Keratin-associated Protein (KAP) Gene Complex on Mouse Chromosome 16 and Evidence for Regulation by Hoxc13 J. Biol. Chem., December 3, 2004; 279(49): 51524 - 51533. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. T. Dorsam, C. M. Ferrell, G. P. Dorsam, M. K. Derynck, U. Vijapurkar, D. Khodabakhsh, B. Pau, H. Bernstein, C. M. Haqq, C. Largman, et al. The transcriptome of the leukemogenic homeoprotein HOXA9 in human hematopoietic cells Blood, March 1, 2004; 103(5): 1676 - 1684. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Ma, J. Liu, T. Wu, M. Plikus, T.-X. Jiang, Q. Bi, Y.-H. Liu, S. Muller-Rover, H. Peters, J. P. Sundberg, et al. `Cyclic alopecia' in Msx2 mutants: defects in hair cycling and hair shaft differentiation Development, March 2, 2003; 130(2): 379 - 389. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Rogers, L. Langbein, H. Winter, C. Ehmann, S. Praetzel, and J. Schweizer Characterization of a First Domain of Human High Glycine-Tyrosine and High Sulfur Keratin-associated Protein (KAP) Genes on Chromosome 21q22.1 J. Biol. Chem., December 6, 2002; 277(50): 48993 - 49002. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. F. Jave-Suarez, H. Winter, L. Langbein, M. A. Rogers, and J. Schweizer HOXC13 Is Involved in the Regulation of Human Hair Keratin Gene Expression J. Biol. Chem., January 25, 2002; 277(5): 3718 - 3726. [Abstract] [Full Text] [PDF]
|
|
