spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Zhang, J.
Right arrow Articles by Sarras, M. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zhang, J.
Right arrow Articles by Sarras, M. P., Jr
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Development, Vol 128, Issue 9 1607-1615, Copyright © 2001 by Company of Biologists

JOURNAL ARTICLES

Molecular and functional evidence for early divergence of an endothelin-like system during metazoan evolution: analysis of the Cnidarian, hydra

J Zhang, A Leontovich and MP Sarras Jr
Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS 666160-7400, USA. msarras@kumc.edu

A novel putative endothelin-converting enzyme (ECE) has been cloned from hydra, a freshwater invertebrate that belongs to the second oldest phylum of the animal kingdom. As an integral component of the endothelin system, vertebrate ECE functions in the activation of endothelin (ET) peptides. Vertebrate ETs are (1) the most potent vasoconstrictors known in mammals; and (2) function as essential signaling ligands during development of tissues derived from neural crest cells. To date, only a limited number of immunocytochemical studies have suggested the presence of endothelin-like peptides in invertebrates. Based on structural and functional analyses, we present evidence for a functional endothelin-like system in hydra that is involved in both muscle contraction and developmental processes. These findings indicate the broad use of endothelin systems in metazoans and also indicate that this type of signaling system arose early in evolution even before divergence of protostomes and deuterostomes.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Mol Biol EvolHome page
I. Braasch, J.-N. Volff, and M. Schartl
The Endothelin System: Evolution of Vertebrate-Specific Ligand-Receptor Interactions by Three Rounds of Genome Duplication
Mol. Biol. Evol., April 1, 2009; 26(4): 783 - 799.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
K. A. Hyndman and D. H. Evans
Endothelin and endothelin converting enzyme-1 in the fish gill: evolutionary and physiological perspectives
J. Exp. Biol., December 15, 2007; 210(24): 4286 - 4297.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
R. A. M. B. Borgheresi, J. M. G. Leroy, A. Yogi, R. A. DosSantos, M. C. Breno, and R. C. Tostes
Pharmacologic and Molecular Characterization of the Vascular ETA Receptor in the Venomous Snake Bothrops jararaca.
Experimental Biology and Medicine, June 1, 2006; 231(6): 729 - 735.
[Abstract] [Full Text] [PDF]

Home page
 Integr. Comp. Biol.Home page
N. W. Blackstone and D. M. Bridge
Model Systems for Environmental Signaling
Integr. Comp. Biol., August 1, 2005; 45(4): 605 - 614.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
H. Shimizu, X. Zhang, J. Zhang, A. Leontovich, K. Fei, L. Yan, and M. P. Sarras Jr.
Epithelial morphogenesis in hydra requires de novo expression of extracellular matrix components and matrix metalloproteinases
Development, March 5, 2003; 129(6): 1521 - 1532.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2001