|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Molecular Biology Program and Division of Biological Sciences, University of Missouri, Columbia, MO 65211, USA
*Author for correspondence (e-mail: RiddleD{at}missouri.edu)
Accepted 11 October 2001
The daf-9 gene functions to integrate transforming growth factor-ß and insulin-like signaling pathways to regulate Caenorhabditis elegans larval development. Mutations in daf-9 result in transient dauer-like larval arrest, abnormal reproductive development, molting defects and increased adult longevity. The phenotype is sterol-dependent, and dependent on the activity of DAF-12, a nuclear hormone receptor. Genetic tests show that daf-9 is upstream of daf-12 in the genetic pathways for larval development and adult longevity. daf-9 encodes a cytochrome P450 related to those involved in biosynthesis of steroid hormones in mammals. We propose that it specifies a step in the biosynthetic pathway for a DAF-12 ligand, which might be a steroid. The surprising cellular specificity of daf-9 expression (predominantly in two sensory neurons) supports a previously unrecognized role for these cells in neuroendocrine control of larval development, reproduction and life span.
Key words: Cytochrome P450, Dauer formation, Aging, daf-9, daf-12, TGF-ß, Insulin
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  A. E. Rougvie miRNA Regulation Through Ligand Occupancy of a Nuclear Hormone Receptor Sci. Signal., August 18, 2009; 2(84): pe52 - pe52. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Bethke, N. Fielenbach, Z. Wang, D. J. Mangelsdorf, and A. Antebi Nuclear Hormone Receptor Regulation of MicroRNAs Controls Developmental Progression Science, April 3, 2009; 324(5923): 95 - 98. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. A. Butcher, J. R. Ragains, W. Li, G. Ruvkun, J. Clardy, and H. Y. Mak Biosynthesis of the Caenorhabditis elegans dauer pheromone PNAS, February 10, 2009; 106(6): 1875 - 1879. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Kleemann, L. Jia, and S. W. Emmons Regulation of Caenorhabditis elegans Male Mate Searching Behavior by the Nuclear Receptor DAF-12 Genetics, December 1, 2008; 180(4): 2111 - 2122. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Butcher, J. R. Ragains, E. Kim, and J. Clardy A potent dauer pheromone component in Caenorhabditis elegans that acts synergistically with other components PNAS, September 23, 2008; 105(38): 14288 - 14292. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Fielenbach and A. Antebi C. elegans dauer formation and the molecular basis of plasticity Genes & Dev., August 15, 2008; 22(16): 2149 - 2165. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. L. Greer and A. Brunet Signaling networks in aging J. Cell Sci., February 15, 2008; 121(4): 407 - 412. [Full Text] [PDF]
|
|
|
|
 |
|
 A.-F. Ruaud and J.-L. Bessereau The P-type ATPase CATP-1 is a novel regulator of C. elegans developmental timing that acts independently of its predicted pump function Development, March 1, 2007; 134(5): 867 - 879. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Hartenstein The neuroendocrine system of invertebrates: a developmental and evolutionary perspective. J. Endocrinol., September 1, 2006; 190(3): 555 - 570. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Baumeister, E. Schaffitzel, and M. Hertweck Endocrine signaling in Caenorhabditis elegans controls stress response and longevity. J. Endocrinol., August 1, 2006; 190(2): 191 - 202. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A.-F. Ruaud and J.-L. Bessereau Activation of nicotinic receptors uncouples a developmental timer from the molting timer in C. elegans Development, June 1, 2006; 133(11): 2211 - 2222. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Fluegel, T. J. Parker, and L. J. Pallanck Mutations of a Drosophila NPC1 Gene Confer Sterol and Ecdysone Metabolic Defects Genetics, January 1, 2006; 172(1): 185 - 196. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E. Rougvie Intrinsic and extrinsic regulators of developmental timing: from miRNAs to nutritional cues Development, September 1, 2005; 132(17): 3787 - 3798. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Yabe, N. Suzuki, T. Furukawa, T. Ishihara, and I. Katsura Multidrug resistance-associated protein MRP-1 regulates dauer diapause by its export activity in Caenorhabditis elegans Development, July 15, 2005; 132(14): 3197 - 3207. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Li, G. Brown, M. Ailion, S. Lee, and J. H. Thomas NCR-1 and NCR-2, the C. elegans homologs of the human Niemann-Pick type C1 disease protein, function upstream of DAF-9 in the dauer formation pathways Development, November 15, 2004; 131(22): 5741 - 5752. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. J. McElwee, E. Schuster, E. Blanc, J. H. Thomas, and D. Gems Shared Transcriptional Signature in Caenorhabditis elegans Dauer Larvae and Long-lived daf-2 Mutants Implicates Detoxification System in Longevity Assurance J. Biol. Chem., October 22, 2004; 279(43): 44533 - 44543. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Shostak, M. R. Van Gilst, A. Antebi, and K. R. Yamamoto Identification of C. elegans DAF-12-binding sites, response elements, and target genes Genes & Dev., October 15, 2004; 18(20): 2529 - 2544. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. P. Grigorenko, Y. K. Moliaka, M. C. Soto, C. C. Mello, and E. I. Rogaev The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins PNAS, October 12, 2004; 101(41): 14955 - 14960. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Ao, J. Gaudet, W. J. Kent, S. Muttumu, and S. E. Mango Environmentally Induced Foregut Remodeling by PHA-4/FoxA and DAF-12/NHR Science, September 17, 2004; 305(5691): 1743 - 1746. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. H. Ludewig, C. Kober-Eisermann, C. Weitzel, A. Bethke, K. Neubert, B. Gerisch, H. Hutter, and A. Antebi A novel nuclear receptor/coregulator complex controls C. elegans lipid metabolism, larval development, and aging Genes & Dev., September 1, 2004; 18(17): 2120 - 2133. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Jia, D. Chen, and D. L. Riddle The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span Development, August 15, 2004; 131(16): 3897 - 3906. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Furuyama, K. Kitayama, Y. Shimoda, M. Ogawa, K. Sone, K. Yoshida-Araki, H. Hisatsune, S.-i. Nishikawa, K. Nakayama, K. Nakayama, et al. Abnormal Angiogenesis in Foxo1 (Fkhr)-deficient Mice J. Biol. Chem., August 13, 2004; 279(33): 34741 - 34749. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Gerisch and A. Antebi Hormonal signals produced by DAF-9/cytochrome P450 regulate C. elegans dauer diapause in response to environmental cues Development, April 15, 2004; 131(8): 1765 - 1776. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Y. Mak and G. Ruvkun Intercellular signaling of reproductive development by the C. elegans DAF-9 cytochrome P450 Development, April 15, 2004; 131(8): 1777 - 1786. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. S. da Graca, K. K. Zimmerman, M. C. Mitchell, M. Kozhan-Gorodetska, K. Sekiewicz, Y. Morales, and G. I. Patterson,, DAF-5 is a Ski oncoprotein homolog that functions in a neuronal TGF{beta} pathway to regulate C. elegans dauer development Development, January 15, 2004; 131(2): 435 - 446. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Ohkura, N. Suzuki, T. Ishihara, and I. Katsura SDF-9, a protein tyrosine phosphatase-like molecule, regulates the L3/dauer developmental decision through hormonal signaling in C. elegans Development, July 15, 2003; 130(14): 3237 - 3248. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Wang and S. K. Kim Global analysis of dauer gene expression in Caenorhabditis elegans Development, April 15, 2003; 130(8): 1621 - 1634. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Tatar Unearthing Loci That Influence Life Span Sci. Aging Knowl. Environ., March 5, 2003; 2003(9): pe5 - 5. [Abstract] [Full Text]
|
|
|
|
|
|
M. Tatar, A. Bartke, and A. Antebi The Endocrine Regulation of Aging by Insulin-like Signals Science, February 28, 2003; 299(5611): 1346 - 1351. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Merris, W. G. Wadsworth, U. Khamrai, R. Bittman, D. J. Chitwood, and J. Lenard Sterol effects and sites of sterol accumulation in Caenorhabditis elegans: developmental requirement for 4{alpha}-methyl sterols J. Lipid Res., January 1, 2003; 44(1): 172 - 181. [Abstract] [Full Text] [PDF]
|
|
