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1 UMR144-CNRS/Institut Curie, 26 rue d’Ulm 75248 Paris cedex 05, France
2 Imperial Cancer Research Fund, Lincoln’s Inn Fields, London WC2A 3PX, UK
3 Kyoto University, Graduate School of Pharmaceutical Sciences, Yoshida-Shimoadachi, Sakyo, Kyoto 606-8501, Japan
4 Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo 113-0032, Japan
* These authors contributed equally to this work
Author for correspondence (e-mail: saverio.bellusci{at}curie.fr)
Accepted 5 October 2001
The mouse develops five pairs of mammary glands that arise during mid-gestation from five pairs of placodes of ectodermal origin. We have investigated the molecular mechanisms of mammary placode development using Lef1 as a marker for the epithelial component of the placode, and mice deficient for Fgf10 or Fgfr2b, both of which fail to develop normal mammary glands. Mammary placode induction involves two different signaling pathways, a FGF10/FGFR2b-dependent pathway for placodes 1, 2, 3 and 5 and a FGF10/FGFR2b-independent pathway for placode 4. Our results also suggest that FGF signaling is involved in the maintenance of mammary bud 4, and that Fgf10 deficient epithelium can undergo branching morphogenesis into the mammary fat pad precursor.
Key words: Fgf10, Fgfr2b, Lef1, Mammary placode development, Mouse, Cell signaling
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