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Development 129, 2773-2783 (2002)
© 2002 The Company of Biologists Limited

DEVELOPMENT AND DISEASE

The meso-angioblast: a multipotent, self-renewing cell that originates from the dorsal aorta and differentiates into most mesodermal tissues

Maria G. Minasi1,2,*, Mara Riminucci3,*, Luciana De Angelis2,*, Ugo Borello1, Barbara Berarducci1, Anna Innocenzi1, Arianna Caprioli4, Dario Sirabella2, Marta Baiocchi2,5, Ruggero De Maria5, Renata Boratto6, Thierry Jaffredo4, Vania Broccoli1, Paolo Bianco7,{dagger} and Giulio Cossu1,2,{dagger}

1 Stem Cell Research Institute, Dibit, H. S. Raffaele, Via Olgettina 58, 20132 Milano, Italy
2 Dipartimento di Istologia ed Embriologia Medica, Universita’ di Roma ‘La Sapienza’ Via Scarpa 14, 00161 Roma, Italy
3 Dipartimento di Medicina Sperimentale, Università de L’Aquila, 67100 L’Aquila, Italy
4 Institut d’Embryologie Cellulaire et Moleculaire du CNRS et du College de France; 49 bis, Avenue de la Belle Gabrielle, Nogent sur Marne, France
5 Laboratorio di Ematologia Oncologia, Istituto Superiore di Sanità, Viale Elena 297, 00161 Roma, Italy
6 Dipartimento di Medicina Sperimentale, Università di Pavia, Via Forlanini 8, 27100 Pavia, Italy
7 Dipartimento di Medicina Sperimentale e Patologia, Universita’ degli Studi di Roma ‘La Sapienza’, Viale Regina Elena 324, 00161 Roma, Italy
* These authors contributed equally to this work

{dagger}Authors for correspondence (e-mail: p.bianco{at}flashnet.it and cossu.giulio{at}hsr.it)

Accepted 8 March 2002

We have previously reported the origin of a class of skeletal myogenic cells from explants of dorsal aorta. This finding disagrees with the known origin of all skeletal muscle from somites and has therefore led us to investigate the in vivo origin of these cells and, moreover, whether their fate is restricted to skeletal muscle, as observed in vitro under the experimental conditions used. To address these issues, we grafted quail or mouse embryonic aorta into host chick embryos. Donor cells, initially incorporated into the host vessels, were later integrated into mesodermal tissues, including blood, cartilage, bone, smooth, skeletal and cardiac muscle. When expanded on a feeder layer of embryonic fibroblasts, the clonal progeny of a single cell from the mouse dorsal aorta acquired unlimited lifespan, expressed hemo-angioblastic markers (CD34, Flk1 and Kit) at both early and late passages, and maintained multipotency in culture or when transplanted into a chick embryo. We conclude that these newly identified vessel-associated stem cells, the meso-angioblasts, participate in postembryonic development of the mesoderm, and we speculate that postnatal mesodermal stem cells may be derived from a vascular developmental origin.

Key words: Stem cells, Endothelium, Pericyte, Angiogenesis, Chimera, Mesoderm, Histogenesis, Mouse, Quail




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