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Development 129, 2891-2903 (2002)
© 2002 The Company of Biologists Limited

ß8 integrins are required for vascular morphogenesis in mouse embryos

Jiangwen Zhu, Karin Motejlek*, Denan Wang, Keling Zang, Andrea Schmidt and Louis F. Reichardt{dagger}

Howard Hughes Medical Institute and Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
* Present address: Department of Pharmacology for Pharmacists Martinistrasse. 52, Institute of Pharmacology, University of Hamburg-UKE, 20251 Hamburg, Germany

{dagger}Author for correspondence (e-mail: lfr{at}cgl.ucsf.edu)

Accepted 2 April 2002

In order to assess the in vivo function of integrins containing the ß8 subunit, we have generated integrin ß8-deficient mice. Ablation of ß8 results in embryonic or perinatal lethality with profound defects in vascular development. Sixty-five percent of integrin ß8-deficient embryos die at midgestation, with evidence of insufficient vascularization of the placenta and yolk sac. The remaining 35% die shortly after birth with extensive intracerebral hemorrhage. Examination of brain tissue from integrin ß8-deficient embryos reveals abnormal vascular morphogenesis resulting in distended and leaky capillary vessels, as well as aberrant brain capillary patterning. In addition, endothelial cell hyperplasia is found in these mutant brains. Expression studies show that integrin ß8 transcripts are localized in endodermal cells surrounding endothelium in the yolk sac and in periventricular cells of the neuroepithelium in the brain. We propose that integrin ß8 is required for vascular morphogenesis by providing proper cues for capillary growth in both yolk sac and embryonic brain. This study thus identifies a molecule crucial for vascular patterning in embryonic yolk sac and brain.

Key words: Integrin, Vasculature, Embryo, Brain, Angiogenesis, Mouse




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© The Company of Biologists Ltd 2002