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Development 129, 2987-2995 (2002)
© 2002 The Company of Biologists Limited

DEVELOPMENT AND DISEASE

Generation of different fates from multipotent muscle stem cells

Michiko R. Wada1,*, Masayo Inagawa-Ogashiwa1,*, Shirabe Shimizu2, Shigeru Yasumoto3 and Naohiro Hashimoto1,{dagger}

1 Stem Cell Research Unit, Mitsubishi Kagaku Institute of Life Sciences, 11 Minamiooya, Machida, Tokyo 194-8511, Japan
2 Department of Plastic Surgery and
3 Laboratory of Molecular Cell Biology and Oncology, Kanagawa Cancer Center Research Institute, Yokohama, Kanagawa 241-0815, Japan
* These authors contributed equally to this work

{dagger}Author for correspondence (e-mail: nao{at}libra.ls.m-kagaku.co.jp)

Accepted 27 March 2002

Although neuronal and mesenchymal stem cells exhibit multipotentiality, this property has not previously been demonstrated for muscle stem cells. We now show that muscle satellite cells of adult mice are able to differentiate into osteoblasts, adipocytes and myotubes. Undifferentiated muscle progenitor cells derived from a single satellite cell co-expressed multiple determination genes including those for MyoD and Runx2, which are specific for myogenic and osteogenic differentiation, respectively. Determination genes not relevant to the induced differentiation pathway were specifically downregulated in these cells. Similar multipotent progenitor cells were isolated from adult human muscle. Based on these observations, we propose a ‘stock options’ model for the generation of different fates from multipotent stem cells.

Key words: Stem cells, Mouse, Fate generation


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© The Company of Biologists Ltd 2002