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Development 129, 3325-3334 (2002)
© 2002 The Company of Biologists Limited

A common translational control mechanism functions in axial patterning and neuroendocrine signaling in Drosophila

Ira E. Clark*, Krista C. Dobi*, Heather K. Duchow*, Anna N. Vlasak{dagger} and Elizabeth R. Gavis{ddagger}

Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
* These authors contributed equally to this work
{dagger} Present address: Department of Biology, University of Pennsylvania, Philadelphia, PA 19104

{ddagger}Author for correspondence (e-mail: lgavis{at}molbio.princeton.edu)

Accepted 20 April 2002

Translational repression of maternal nanos (nos) mRNA by a cis-acting Translational Control Element (TCE) in the nos 3'UTR is critical for anterior-posterior patterning of the Drosophila embryo. We show, through ectopic expression experiments, that the nos TCE is capable of repressing gene expression at later stages of development in neuronal cells that regulate the molting cycle. Our results predict additional targets of TCE-mediated repression within the nervous system. They also suggest that mechanisms that regulate maternal mRNAs, like TCE-mediated repression, may function more widely during development to spatially or temporally control gene expression.

Key words: nanos, Translational control, Neuroendocrine, 3' untranslated region, Drosophila


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© The Company of Biologists Ltd 2002