QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Clark, I. E. Articles by Gavis, E. R. Search for Related Content PubMed PubMed Citation Articles by Clark, I. E. Articles by Gavis, E. R.

A common translational control mechanism functions in axial patterning and neuroendocrine signaling in Drosophila

Ira E. Clark^*, Krista C. Dobi^*, Heather K. Duchow^*, Anna N. Vlasak and Elizabeth R. Gavis

Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
^* These authors contributed equally to this work
Present address: Department of Biology, University of Pennsylvania, Philadelphia, PA 19104

Author for correspondence (e-mail: lgavis{at}molbio.princeton.edu)

Accepted 20 April 2002

Translational repression of maternal nanos (nos) mRNA by a cis-acting Translational Control Element (TCE) in the nos 3'UTR is critical for anterior-posterior patterning of the Drosophila embryo. We show, through ectopic expression experiments, that the nos TCE is capable of repressing gene expression at later stages of development in neuronal cells that regulate the molting cycle. Our results predict additional targets of TCE-mediated repression within the nervous system. They also suggest that mechanisms that regulate maternal mRNAs, like TCE-mediated repression, may function more widely during development to spatially or temporally control gene expression.

Key words: nanos, Translational control, Neuroendocrine, 3' untranslated region, Drosophila