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Development 129, 3493-3503 (2002)
© 2002 The Company of Biologists Limited

Planar cell polarization requires Widerborst, a B' regulatory subunit of protein phosphatase 2A

Michael Hannus*, Fabian Feiguin{dagger}, Carl-Philipp Heisenberg and Suzanne Eaton{ddagger}

Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse-108, 01307 Dresden, Germany
* Present address: Cenix Biosciences, Pfotenhauerstrasse-108, 01307 Dresden, Germany
{dagger} Present address: Institute for Molecular Pathology, Vienna, Austria

{ddagger}Author for correspondence (e-mail: eaton{at}mpi-cbg.de)

Accepted 26 April 2002

We have identified widerborst (wdb), a B' regulatory subunit of PP2A, as a conserved component of planar cell polarization mechanisms in both Drosophila and in zebrafish. In Drosophila, wdb acts at two steps during planar polarization of wing epithelial cells. It is required to organize tissue polarity proteins into proximal and distal cortical domains, thus determining wing hair orientation. It is also needed to generate the polarized membrane outgrowth that becomes the wing hair. Widerborst activates the catalytic subunit of PP2A and localizes to the distal side of a planar microtubule web that lies at the level of apical cell junctions. This suggests that polarized PP2A activation along the planar microtubule web is important for planar polarization. In zebrafish, two wdb homologs are required for convergent extension during gastrulation, supporting the conjecture that Drosophila planar cell polarization and vertebrate gastrulation movements are regulated by similar mechanisms.

Key words: Drosophila, Widerborst, PP2A, Zebrafish, Planar polarity




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© The Company of Biologists Ltd 2002