spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Marino, S.
Right arrow Articles by Brandner, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Marino, S.
Right arrow Articles by Brandner, S.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?
Development 129, 3513-3522 (2002)
© 2002 The Company of Biologists Limited

DEVELOPMENT AND DISEASE

PTEN is essential for cell migration but not for fate determination and tumourigenesis in the cerebellum

Silvia Marino1,{dagger}, Paul Krimpenfort2, Carly Leung1, Hetty A. G. M. van der Korput3, Jan Trapman3, Isabelle Camenisch1, Anton Berns2 and Sebastian Brandner4,*,{dagger}

1 Institute of Pathology, University Hospital, 8091 Zurich, Switzerland
2 Division of Molecular Genetics and Centre of Biomedical Genetics, The Netherlands Cancer Institute, CX 1066 Amsterdam, The Netherlands
3 Department of Pathology, Erasmus University, 3000 DR Rotterdam, The Netherlands
4 Institute of Neuropathology, University Hospital, 8091 Zurich, Switzerland
* Present address: Institute of Neurology, Queen Square, London WC1N 3BG, UK

{dagger}Authors for correspondence (e-mail: silvia.marino{at}pty.usz.ch or sebastian.brandner{at}prion.ucl.ac.uk)

Accepted 2 May 2002

PTEN is a tumour suppressor gene involved in cell cycle control, apoptosis and mediation of adhesion and migration signalling. Germline mutations of PTEN in humans are associated with familial tumour syndromes, among them Cowden disease. Glioblastomas, highly malignant glial tumours of the central nervous system frequently show loss of PTEN. Recent reports have outlined some aspects of PTEN function in central nervous system development. Using a conditional gene disruption approach, we inactivated Pten in mice early during embryogenesis locally in a region specific fashion and later during postnatal development in a cell-specific manner, to study the role of PTEN in differentiation, migration and neoplastic transformation. We show that PTEN is required for the realisation of normal cerebellar architecture, for regulation of cell and organ size, and for proper neuronal and glial migration. However, PTEN is not required for cell differentiation and lack of PTEN is not sufficient to induce neoplastic transformation of neuronal or glial cells

Key words: PTEN, Cerebellum, Cre-LoxP, Lhermitte-Duclos Syndrome, Mouse


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?




© The Company of Biologists Ltd 2002