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Development 129, 3803-3814 (2002)
© 2002 The Company of Biologists Limited

Dynamic microtubule-dependent interactions position homotypic neurones in regular monolayered arrays during retinal development

Lucia Galli-Resta1,*, Elena Novelli1 and Alessandro Viegi2

1 Istituto di Neuroscienze CNR, Laboratorio di Neurofisiologia, Via G. Moruzzi 1, 56100 Pisa, Italy
2 Scuola Normale Superiore, Via G. Moruzzi 1, 56100 Pisa, Italy

*Author for correspondence (e-mail: galli{at}in.pi.cnr.it)

Accepted 21 May 2002

In the vertebrate retina cell layers support serial processing, while monolayered arrays of homotypic neurones tile each layer to allow parallel processing. How neurones form layers and arrays is still largely unknown. We show that monolayered retinal arrays are dynamic structures based on dendritic interactions between the array cells. The analysis of three developing retinal arrays shows that these become regular as a net of dendritic processes links neighbouring array cells. Molecular or pharmacological perturbations of microtubules within dendrites lead to a stereotyped and reversible disruption of array organization: array cells lose their regular spacing and the arrangement in a monolayer. This leads to a micro-mechanical explanation of how monolayers of regularly spaced ‘like-cells’ are formed.

Key words: Retina, Retinal mosaics, Patterning, Dendritic interactions, Microtubules, Rat




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© The Company of Biologists Ltd 2002